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CAS No.: 80321-63-7
Synonyms: Gynostemma Pentaphyllum;Gypenoside;Ginsenoside C Mx1
Gynostemma extract, a natural product isolated and purified from the herb of Gynostemma pentaphyllum (Thunb.) Makino., induces apoptosis in human hepatoma cells through the up-regulation of Bax and Bak, and down-regulation of Bcl-2, release of mitochondrial cytochrome c and activation of caspase cascade, induces ER stress and production of reactive oxygen species and Ca 2+ , changes the ratio of Bcl-2 and Bax, followed by the dysfunction of mitochondria, and causes cytochrome c release, activation of caspase-3 before leading to apoptosis.
生物活性
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|---|---|---|---|---|
NCT01667224 | - | - | Completed | - | - |
NCT01667224 | Obesity | Phase 2 | Completed | - | - |
NCT02188251 | Body Weight | Phase 2 | Completed | - | Canada, Ontario ... more >> KGK Synergize Inc. London, Ontario, Canada, N6A 5R8 Collapse << |
实验方案
技术信息
CAS号 | 80321-63-7 | 储存条件 |
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分子式 | C47H80O17 | 运输 | 蓝冰 | |
分子量 | 917.13 | 别名 | Gynostemma Pentaphyllum;Gypenoside;Ginsenoside C Mx1;Gynosaponin-I;Notoginsenoside Fd |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|
NCT01667224 | - | - | Completed | - | - |
NCT01667224 | Obesity | Phase 2 | Completed | - | - |
NCT02188251 | Body Weight | Phase 2 | Completed | - | Canada, Ontario ... more >> KGK Synergize Inc. London, Ontario, Canada, N6A 5R8 Collapse << |
NCT01254084 | Type 2 Diabetes | Phase 1 Phase 2 | Completed | - | Vietnam ... more >> National Institute of Gerontology, HMU Hanoi, Vietnam National Institute of Gerontology Hanoi, Vietnam Collapse << |
NCT00808860 | Type 2 Diabetes | Phase 1 Phase 2 | Completed | - | Vietnam ... more >> National Institute of Gerontology, HMU Hanoi, Vietnam Collapse << |
NCT00786500 | Type 2 Diabetes | Phase 1 Phase 2 | Completed | - | Vietnam ... more >> National Institute of Gerontology, HMU Hanoi, Vietnam Collapse << |
NCT03277833 | Chronic Stress-Induced Strain | Not Applicable | Completed | - | - |
NCT03372109 | Body Weight Changes | Not Applicable | Completed | - | United States, Florida ... more >> Life Extension Clinical Research, Inc. Fort Lauderdale, Florida, United States, 33308 Collapse << |
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