CAS No.: 306974-70-9
GW-1100 Catalog No. CSN16522
GW1100 is a selective antagonist of GPR40-mediated Ca2+ elevations in HEK293 cells stimulated by GW 9508 or linoleic acid with a pIC50 value equal to 5.99.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Stoddart LA, Brown AJ, et al. Uncovering the pharmacology of the G protein-coupled receptor GPR40: high apparent constitutive activity in guanosine 5'-O-(3-[35S] thio)triphosphate binding studies reflects binding of an endogenous agonist. Mol Pharmacol. 2007 Apr;71(4):994-1005. Epub 2007 Jan 2.
- [2] Briscoe CP, Peat AJ, et al. Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules. Br J Pharmacol. 2006 Jul;148(5):619-28.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 306974-70-9 | 储存条件 |
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| 分子式 | C27H25FN4O4S | 运输 | 蓝冰 | |
| 分子量 | 520.58 | 别名 |
