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CAS No.: 489-84-9

Guaiazulene/愈疮奥 Catalog No. CSN23313

Synonyms: azulon;Vetivazulen;1,4-dimethyl-7-isopropylazulene

Guaiazulene is a derivative of azulene can be used as skin care products ingredients and volatile dye.

规格	价格	促销价格	库存	数量

400-920-2911

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技术信息

生物活性

描述Guaiazulene is present in several essential oils of medicinal and aromatic plants, with antioxidant activity. Guaiazulene can inhibit lipid peroxidation very significantly, having an IC50 value of 9.8 microM. It can also scavenge hydroxyl radicals and interact with DPPH (1,1-diphenyl-2-picrylhydrazyl radical). The significant protection against paracetamol-induced GSH depletion and hepatic damage afforded by guaiazulene is probably connected with its antioxidant activity^[2]. GYZ (Guaiazulene) induced complete autophagic flux in NSCLC (Non-small cell lung cancer) cells via inhibiting the Akt/mTOR signaling pathway, which displayed cytoprotective effect against GYZ-induced growth suppression^[3]. GYZ have anti-proliferative activity suppressing the proliferation of neuron and N2a-NB cells at high doses. In addition, GYZ treatments at higher doses led to decreases of TAC (total antioxidant capacity) levels and increases of TOS (total oxidative stress) levels in neuron and N2a-NB cells^[4].
参考文献

[2] Kourounakis AP, Rekka EA, Kourounakis PN. Antioxidant activity of guaiazulene and protection against paracetamol hepatotoxicity in rats. J Pharm Pharmacol. 1997 Sep;49(9):938-42
[3] Ye Q, Zhou L, Jin P, Li L, Zheng S, Huang Z, Liu J, Qin S, Liu H, Zou B, Xie K. Guaiazulene Triggers ROS-Induced Apoptosis and Protective Autophagy in Non-small Cell Lung Cancer. Front Pharmacol. 2021 Apr 15;12:621181
[4] Togar B, Turkez H, Hacimuftuoglu A, Tatar A, Geyikoglu F. Guaiazulene biochemical activity and cytotoxic and genotoxic effects on rat neuron and N2a neuroblastom cells. J Intercult Ethnopharmacol. 2015 Jan-Mar;4(1):29-33

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 5.0429 mL
- 25.2143 mL
- 50.4286 mL
- 5 mM
- 1.0086 mL
- 5.0429 mL
- 10.0857 mL
- 10 mM
- 0.5043 mL
- 2.5214 mL
- 5.0429 mL

技术信息

CAS号

489-84-9

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C15H18

运输

蓝冰

分子量

198.30

别名

azulon;Vetivazulen;1,4-dimethyl-7-isopropylazulene;NSC 4714;愈疮奥;愈创木烯

溶解度

DMSO	240.0 mg/mL (1210.3 mM) warming

动物实验配方

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Guaiazulene/愈疮奥 Catalog No. CSN23313

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