|N-(3-((2-(4-氨基呋咱-3-基)-1-乙基-1H-咪唑并[4,5-c]吡啶-6-基)氧)苯基)-4-((2-(4-吗啉基)乙基)氧)苯甲酰胺盐酸盐|CsnPharm

CAS No.: 2095432-71-4

GSK269962A HCl Catalog No. CSN19208

Synonyms: GSK 269962 hydrochloride;GSK-269962A HCl;GSK-269962B HCl

GSK269962 HCl is a selective ROCK (Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.

规格	价格	促销价格	库存	数量

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靶点选择性

生物活性

实验方案

技术信息

生物活性

靶点 ROCK1

IC50:1.6nM ROCK2

IC50:4nM
描述GSK269962A can potently inhibit ROCK enzymatic activity with IC50 values of 1.6nM and 4nM for ROCK1 and ROCK2 (measured by purified recombinant protein), respectively, also show inhibition against RSK1 and MSK1 with IC50 values of 132nM and 49nM. Pre-treatment with 3μM GSK269962A 30 minutes before AngII stimulation could inhibit the actin stress fiber formation induced by AngII in human primary aortic smooth muscle cells. Addition with GSK269962A into the tissue bath showed concentration-dependent relaxing effect with IC50 value of 35nM on contracted blood vessels induced by phenylephrine in vitro due to the inhibition of ROCK inhibition by GSK269962A. Oral administration of 0.3-3mg/kg GSK269962A dose-dependently reduced blood pressure in both SHR and DOCA-treated hypertensive rats. GSK269962A at concentration of 50nM could dramatically inhibit basal myometrial contraction at 72h and abolish the procontractile effect of LPS, but appeared to enhance LPS-induced secretion of IL-8 in PHM1-41 cells.
细胞研究

Cell Data

Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources
697 cell	-	Growth inhibition assay	-	Inhibition of human 697 cell growth in a cell viability assay, IC50=0.2991 μM	SANGER
8-MG-BA cell	-	Growth inhibition assay	-	Inhibition of human 8-MG-BA cell growth in a cell viability assay, IC50=23.0793 μM	SANGER
A101D cell	-	Growth inhibition assay	-	Inhibition of human A101D cell growth in a cell viability assay, IC50=1.87034 μM	SANGER

更多
动物研究
剂量
Rat: 30 mg/kg^[2] (i.v.); 1 mg/kg- 30 mg/kg^[3] (p.o.); 5 mg/kg, 10 mg/kg^[4] (intra-arterially)

给药途径
i.v., p.o., intra-arterially
参考文献

动物研究
剂量	Rat: 30 mg/kg^[2] (i.v.); 1 mg/kg- 30 mg/kg^[3] (p.o.); 5 mg/kg, 10 mg/kg^[4] (intra-arterially)
给药途径	i.v., p.o., intra-arterially

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.6473 mL
- 8.2364 mL
- 16.4728 mL
- 5 mM
- 0.3295 mL
- 1.6473 mL
- 3.2946 mL
- 10 mM
- 0.1647 mL
- 0.8236 mL
- 1.6473 mL

技术信息

CAS号

2095432-71-4

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C29H31ClN8O5

运输

蓝冰

分子量

607.06

别名

GSK 269962 hydrochloride;GSK-269962A HCl;GSK-269962B HCl;GSK269962 HCl;GSK-269962;GSK-269962A;GSK26996B

溶解度

DMSO	33.0 mg/mL (54.4 mM) warming
Water	insoluble

动物实验配方

IP	2% DMSO+water	0.7 mg/mL	clear
PO	0.5% CMC-Na	40 mg/mL	suspension

大规格询价

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Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources

697 cell	-	Growth inhibition assay	-	Inhibition of human 697 cell growth in a cell viability assay, IC50=0.2991 μM	SANGER
8-MG-BA cell	-	Growth inhibition assay	-	Inhibition of human 8-MG-BA cell growth in a cell viability assay, IC50=23.0793 μM	SANGER
A101D cell	-	Growth inhibition assay	-	Inhibition of human A101D cell growth in a cell viability assay, IC50=1.87034 μM	SANGER
ACN cell	-	Growth inhibition assay	-	Inhibition of human ACN cell growth in a cell viability assay, IC50=21.4387 μM	SANGER
AM-38 cell	-	Growth inhibition assay	-	Inhibition of human AM-38 cell growth in a cell viability assay, IC50=7.26327 μM	SANGER
ATN-1 cell	-	Growth inhibition assay	-	Inhibition of human ATN-1 cell growth in a cell viability assay, IC50=24.7555 μM	SANGER
BB30-HNC cell	-	Growth inhibition assay	-	Inhibition of human BB30-HNC cell growth in a cell viability assay, IC50=22.2532 μM	SANGER
BB49-HNC cell	-	Growth inhibition assay	-	Inhibition of human BB49-HNC cell growth in a cell viability assay, IC50=0.00789 μM	SANGER
BE-13 cell	-	Growth inhibition assay	-	Inhibition of human BE-13 cell growth in a cell viability assay, IC50=0.14081μM	SANGER
Becker cell	-	Growth inhibition assay	-	Inhibition of human Becker cell growth in a cell viability assay, IC50=13.9545 μM	SANGER
BL-70 cell	-	Growth inhibition assay	-	Inhibition of human BL-70 cell growth in a cell viability assay, IC50=3.40703 μM	SANGER
BV-173 cell	-	Growth inhibition assay	-	Inhibition of human BV-173 cell growth in a cell viability assay, IC50=18.8859 μM	SANGER
CAL-148 cell	-	Growth inhibition assay	-	Inhibition of human CAL-148 cell growth in a cell viability assay, IC50=35.6557 μM	SANGER
Calu-6 cell	-	Growth inhibition assay	-	Inhibition of human Calu-6 cell growth in a cell viability assay, IC50=47.586 μM	SANGER
CAS-1 cell	-	Growth inhibition assay	-	Inhibition of human CAS-1 cell growth in a cell viability assay, IC50=0.847 μM	SANGER
CCRF-CEM cell	-	Growth inhibition assay	-	Inhibition of human CCRF-CEM cell growth in a cell viability assay, IC50=8.65392 μM	SANGER
CMK cell	-	Growth inhibition assay	-	Inhibition of human CMK cell growth in a cell viability assay, IC50=1.01323 μM	SANGER
COLO-829 cell	-	Growth inhibition assay	-	Inhibition of human COLO-829 cell growth in a cell viability assay, IC50=3.24226 μM	SANGER
COR-L279 cell	-	Growth inhibition assay	-	Inhibition of human COR-L279 cell growth in a cell viability assay, IC50=2.0738 μM	SANGER
CP66-MEL cell	-	Growth inhibition assay	-	Inhibition of human CP66-MEL cell growth in a cell viability assay, IC50=36.5497 μM	SANGER
CRO-AP2 cell	-	Growth inhibition assay	-	Inhibition of human CRO-AP2 cell growth in a cell viability assay, IC50=2.36088 μM	SANGER
CTV-1 cell	-	Growth inhibition assay	-	Inhibition of human CTV-1 cell growth in a cell viability assay, IC50=23.9145 μM	SANGER
D-247MG cell	-	Growth inhibition assay	-	Inhibition of human D-247MG cell growth in a cell viability assay, IC50=0.62814 μM	SANGER
D-263MG cell	-	Growth inhibition assay	-	Inhibition of human D-263MG cell growth in a cell viability assay, IC50=0.08509 μM	SANGER
D-336MG cell	-	Growth inhibition assay	-	Inhibition of human D-336MG cell growth in a cell viability assay, IC50=0.62854 μM	SANGER
D-392MG cell	-	Growth inhibition assay	-	Inhibition of human D-392MG cell growth in a cell viability assay, IC50=1.43039 μM	SANGER
D-502MG cell	-	Growth inhibition assay	-	Inhibition of human D-502MG cell growth in a cell viability assay, IC50=8.53492 μM	SANGER
D-542MG cell	-	Growth inhibition assay	-	Inhibition of human D-542MG cell growth in a cell viability assay, IC50=12.3152 μM	SANGER
Daudi cell	-	Growth inhibition assay	-	Inhibition of human Daudi cell growth in a cell viability assay, IC50=2.09802 μM	SANGER
DB cell	-	Growth inhibition assay	-	Inhibition of human DB cell growth in a cell viability assay, IC50=47.1417 μM	SANGER
DEL cell	-	Growth inhibition assay	-	Inhibition of human DEL cell growth in a cell viability assay, IC50=7.01898 μM	SANGER
DMS-114 cell	-	Growth inhibition assay	-	Inhibition of human DMS-114 cell growth in a cell viability assay, IC50=49.8468 μM	SANGER
DMS-153 cell	-	Growth inhibition assay	-	Inhibition of human DMS-153 cell growth in a cell viability assay, IC50=42.9923 μM	SANGER
DOHH-2 cell	-	Growth inhibition assay	-	Inhibition of human DOHH-2 cell growth in a cell viability assay, IC50=4.22764 μM	SANGER
DSH1 cell	-	Growth inhibition assay	-	Inhibition of human DSH1 cell growth in a cell viability assay, IC50=8.43623 μM	SANGER
ECC4 cell	-	Growth inhibition assay	-	Inhibition of human ECC4 cell growth in a cell viability assay, IC50=32.1896 μM	SANGER
EC-GI-10 cell	-	Growth inhibition assay	-	Inhibition of human EC-GI-10 cell growth in a cell viability assay, IC50=44.2589 μM	SANGER
EM-2 cell	-	Growth inhibition assay	-	Inhibition of human EM-2 cell growth in a cell viability assay, IC50=2.45594 μM	SANGER
ES1 cell	-	Growth inhibition assay	-	Inhibition of human ES1 cell growth in a cell viability assay, IC50=5.54087 μM	SANGER
ES3 cell	-	Growth inhibition assay	-	Inhibition of human ES3 cell growth in a cell viability assay, IC50=42.4729 μM	SANGER
ES4 cell	-	Growth inhibition assay	-	Inhibition of human ES4 cell growth in a cell viability assay, IC50=35.195 μM	SANGER
ES6 cell	-	Growth inhibition assay	-	Inhibition of human ES6 cell growth in a cell viability assay, IC50=0.24733 μM	SANGER
ES7 cell	-	Growth inhibition assay	-	Inhibition of human ES7 cell growth in a cell viability assay, IC50=5.23124 μM	SANGER
ES8 cell	-	Growth inhibition assay	-	Inhibition of human ES8 cell growth in a cell viability assay, IC50=0.81924 μM	SANGER
EW-18 cell	-	Growth inhibition assay	-	Inhibition of human EW-18 cell growth in a cell viability assay, IC50=13.6759 μM	SANGER
EW-22 cell	-	Growth inhibition assay	-	Inhibition of human EW-22 cell growth in a cell viability assay, IC50=47.7947 μM	SANGER
GCIY cell	-	Growth inhibition assay	-	Inhibition of human GCIY cell growth in a cell viability assay, IC50=9.80389 μM	SANGER
GDM-1 cell	-	Growth inhibition assay	-	Inhibition of human GDM-1 cell growth in a cell viability assay, IC50=8.39196 μM	SANGER
GI-1 cell	-	Growth inhibition assay	-	Inhibition of human GI-1 cell growth in a cell viability assay, IC50=0.00523 μM	SANGER
GI-ME-N cell	-	Growth inhibition assay	-	Inhibition of human GI-ME-N cell growth in a cell viability assay, IC50=0.04951 μM	SANGER
GR-ST cell	-	Growth inhibition assay	-	Inhibition of human GR-ST cell growth in a cell viability assay, IC50=13.7902 μM	SANGER
GT3TKB cell	-	Growth inhibition assay	-	Inhibition of human GT3TKB cell growth in a cell viability assay, IC50=1.60389 μM	SANGER
HAL-01 cell	-	Growth inhibition assay	-	Inhibition of human HAL-01 cell growth in a cell viability assay, IC50=6.69712 μM	SANGER
HCC1599 cell	-	Growth inhibition assay	-	Inhibition of human HCC1599 cell growth in a cell viability assay, IC50=37.6011 μM	SANGER
HCC2218 cell	-	Growth inhibition assay	-	Inhibition of human HCC2218 cell growth in a cell viability assay, IC50=13.3834 μM	SANGER
HD-MY-Z cell	-	Growth inhibition assay	-	Inhibition of human HD-MY-Z cell growth in a cell viability assay, IC50=25.2146 μM	SANGER
HL-60 cell	-	Growth inhibition assay	-	Inhibition of human HL-60 cell growth in a cell viability assay, IC50=12.2114 μM	SANGER
HOP-62 cell	-	Growth inhibition assay	-	Inhibition of human HOP-62 cell growth in a cell viability assay, IC50=23.9527 μM	SANGER
HT cell	-	Growth inhibition assay	-	Inhibition of human HT cell growth in a cell viability assay, IC50=4.44321 μM	SANGER
HT-144 cell	-	Growth inhibition assay	-	Inhibition of human HT-144 cell growth in a cell viability assay, IC50=4.90686 μM	SANGER
human BC-1 cell	-	Growth inhibition assay	-	Inhibition of human BC-1 cell growth in a cell viability assay, IC50=3.97107 μM	SANGER
HUTU-80 cell	-	Growth inhibition assay	-	Inhibition of human HUTU-80 cell growth in a cell viability assay, IC50=3.78986 μM	SANGER
IST-MEL1 cell	-	Growth inhibition assay	-	Inhibition of human IST-MEL1 cell growth in a cell viability assay, IC50=32.9086 μM	SANGER
IST-SL1 cell	-	Growth inhibition assay	-	Inhibition of human IST-SL1 cell growth in a cell viability assay, IC50=2.17079 μM	SANGER
IST-SL2 cell	-	Growth inhibition assay	-	Inhibition of human IST-SL2 cell growth in a cell viability assay, IC50=3.26608 μM	SANGER
JiyoyeP-2003 cell	-	Growth inhibition assay	-	Inhibition of human JiyoyeP-2003 cell growth in a cell viability assay, IC50=36.6284 μM	SANGER
K052 cell	-	Growth inhibition assay	-	Inhibition of human K052 cell growth in a cell viability assay, IC50=0.75301 μM	SANGER
K5 cell	-	Growth inhibition assay	-	Inhibition of human K5 cell growth in a cell viability assay, IC50=33.5915 μM	SANGER
KALS-1 cell	-	Growth inhibition assay	-	Inhibition of human KALS-1 cell growth in a cell viability assay, IC50=29.3969 μM	SANGER
KARPAS-422 cell	-	Growth inhibition assay	-	Inhibition of human KARPAS-422 cell growth in a cell viability assay, IC50=42.9142 μM	SANGER
KARPAS-45 cell	-	Growth inhibition assay	-	Inhibition of human KARPAS-45 cell growth in a cell viability assay, IC50=4.11247 μM	SANGER
KE-37 cell	-	Growth inhibition assay	-	Inhibition of human KE-37 cell growth in a cell viability assay, IC50=9.835 μM	SANGER
KG-1 cell	-	Growth inhibition assay	-	Inhibition of human KG-1 cell growth in a cell viability assay, IC50=23.9757 μM	SANGER
KGN cell	-	Growth inhibition assay	-	Inhibition of human KGN cell growth in a cell viability assay, IC50=0.56742 μM	SANGER
KM12 cell	-	Growth inhibition assay	-	Inhibition of human KM12 cell growth in a cell viability assay, IC50=3.52964 μM	SANGER
KMOE-2 cell	-	Growth inhibition assay	-	Inhibition of human KMOE-2 cell growth in a cell viability assay, IC50=30.4549 μM	SANGER
KNS-42 cell	-	Growth inhibition assay	-	Inhibition of human KNS-42 cell growth in a cell viability assay, IC50=8.81915 μM	SANGER
KNS-81-FD cell	-	Growth inhibition assay	-	Inhibition of human KNS-81-FD cell growth in a cell viability assay, IC50=37.426 μM	SANGER
KS-1 cell	-	Growth inhibition assay	-	Inhibition of human KS-1 cell growth in a cell viability assay, IC50=0.0046 μM	SANGER
KU812 cell	-	Growth inhibition assay	-	Inhibition of human KU812 cell growth in a cell viability assay, IC50=23.484 μM	SANGER
L-540 cell	-	Growth inhibition assay	-	Inhibition of human L-540 cell growth in a cell viability assay, IC50=20.7445 μM	SANGER
LAMA-84 cell	-	Growth inhibition assay	-	Inhibition of human LAMA-84 cell growth in a cell viability assay, IC50=13.6742 μM	SANGER
LB1047-RCC cell	-	Growth inhibition assay	-	Inhibition of human LB1047-RCC cell growth in a cell viability assay, IC50=28.3883 μM	SANGER
LB2241-RCC cell	-	Growth inhibition assay	-	Inhibition of human LB2241-RCC cell growth in a cell viability assay, IC50=10.5536 μM	SANGER
LB2518-MEL cell	-	Growth inhibition assay	-	Inhibition of human LB2518-MEL cell growth in a cell viability assay, IC50=1.71496μM	SANGER
LB831-BLC cell	-	Growth inhibition assay	-	Inhibition of human LB831-BLC cell growth in a cell viability assay, IC50=11.1726 μM	SANGER
LB996-RCC cell	-	Growth inhibition assay	-	Inhibition of human LB996-RCC cell growth in a cell viability assay, IC50=12.7431 μM	SANGER
LC4-1 cell	-	Growth inhibition assay	-	Inhibition of human LC4-1 cell growth in a cell viability assay, IC50=32.8341 μM	SANGER
LOUCY cell	-	Growth inhibition assay	-	Inhibition of human LOUCY cell growth in a cell viability assay, IC50=1.15276 μM	SANGER
LOXIMVI cell	-	Growth inhibition assay	-	Inhibition of human LOXIMVI cell growth in a cell viability assay, IC50=30.2122 μM	SANGER
LS-123 cell	-	Growth inhibition assay	-	Inhibition of human LS-123 cell growth in a cell viability assay, IC50=39.2258 μM	SANGER
LU-134-A cell	-	Growth inhibition assay	-	Inhibition of human LU-134-A cell growth in a cell viability assay, IC50=7.14068 μM	SANGER
LU-139 cell	-	Growth inhibition assay	-	Inhibition of human LU-139 cell growth in a cell viability assay, IC50=22.218 μM	SANGER
LXF-289 cell	-	Growth inhibition assay	-	Inhibition of human LXF-289 cell growth in a cell viability assay, IC50=17.4351μM	SANGER
MC116 cell	-	Growth inhibition assay	-	Inhibition of human MC116 cell growth in a cell viability assay, IC50=45.0841 μM	SANGER
MDA-MB-134-VI cell	-	Growth inhibition assay	-	Inhibition of human MDA-MB-134-VI cell growth in a cell viability assay, IC50=39.2486 μM	SANGER
MFH-ino cell	-	Growth inhibition assay	-	Inhibition of human MFH-ino cell growth in a cell viability assay, IC50=0.64383 μM	SANGER
MHH-NB-11 cell	-	Growth inhibition assay	-	Inhibition of human MHH-NB-11 cell growth in a cell viability assay, IC50=0.0669 μM	SANGER
ML-2 cell	-	Growth inhibition assay	-	Inhibition of human ML-2 cell growth in a cell viability assay, IC50=3.40304 μM	SANGER
MOLT-13 cell	-	Growth inhibition assay	-	Inhibition of human MOLT-13 cell growth in a cell viability assay, IC50=4.43653 μM	SANGER
MOLT-16 cell	-	Growth inhibition assay	-	Inhibition of human MOLT-16 cell growth in a cell viability assay, IC50=4.11163 μM	SANGER
MOLT-4 cell	-	Growth inhibition assay	-	Inhibition of human MOLT-4 cell growth in a cell viability assay, IC50=14.4124 μM	SANGER
MPP-89 cell	-	Growth inhibition assay	-	Inhibition of human MPP-89 cell growth in a cell viability assay, IC50=1.25922 μM	SANGER
MRK-nu-1 cell	-	Growth inhibition assay	-	Inhibition of human MRK-nu-1 cell growth in a cell viability assay, IC50=0.57572 μM	SANGER
MSTO-211H cell	-	Growth inhibition assay	-	Inhibition of human MSTO-211H cell growth in a cell viability assay, IC50=12.869 μM	SANGER
MV-4-11 cell	-	Growth inhibition assay	-	Inhibition of human MV-4-11 cell growth in a cell viability assay, IC50=0.13915 μM	SANGER
NALM-6 cell	-	Growth inhibition assay	-	Inhibition of human NALM-6 cell growth in a cell viability assay, IC50=1.56109 μM	SANGER
NB1 cell	-	Growth inhibition assay	-	Inhibition of human NB1 cell growth in a cell viability assay, IC50=3.84369 μM	SANGER
NB10 cell	-	Growth inhibition assay	-	Inhibition of human NB10 cell growth in a cell viability assay, IC50=0.13915 μM	SANGER
NB12 cell	-	Growth inhibition assay	-	Inhibition of human NB12 cell growth in a cell viability assay, IC50=16.5656 μM	SANGER
NB13 cell	-	Growth inhibition assay	-	Inhibition of human NB13 cell growth in a cell viability assay, IC50=2.31278 μM	SANGER
NB17 cell	-	Growth inhibition assay	-	Inhibition of human NB17 cell growth in a cell viability assay, IC50=3.58051 μM	SANGER
NB6 cell	-	Growth inhibition assay	-	Inhibition of human NB6 cell growth in a cell viability assay, IC50=0.59114 μM	SANGER
NCCIT cell	-	Growth inhibition assay	-	Inhibition of human NCCIT cell growth in a cell viability assay, IC50=41.8453 μM	SANGER
NCI-H1155 cell	-	Growth inhibition assay	-	Inhibition of human NCI-H1155 cell growth in a cell viability assay, IC50=14.3408 μM	SANGER
NCI-H1304 cell	-	Growth inhibition assay	-	Inhibition of human NCI-H1304 cell growth in a cell viability assay, IC50=11.8982 μM	SANGER
NCI-H1355 cell	-	Growth inhibition assay	-	Inhibition of human NCI-H1355 cell growth in a cell viability assay, IC50=4.9411 μM	SANGER
NCI-H1395 cell	-	Growth inhibition assay	-	Inhibition of human NCI-H1395 cell growth in a cell viability assay, IC50=22.8795 μM	SANGER
NCI-H1417 cell	-	Growth inhibition assay	-	Inhibition of human NCI-H1417 cell growth in a cell viability assay, IC50=5.67522 μM	SANGER
NCI-H1436 cell	-	Growth inhibition assay	-	Inhibition of human NCI-H1436 cell growth in a cell viability assay, IC50=3.84101 μM	SANGER
NCI-H1581	-	Growth inhibition assay	-	Inhibition of human NCI-H1581 cell growth in a cell viability assay, IC50=18.8477 μM	SANGER
NCI-H1694	-	Growth inhibition assay	-	Inhibition of human NCI-H1694 cell growth in a cell viability assay, IC50=24.8749 μM	SANGER
NCI-H1963	-	Growth inhibition assay	-	Inhibition of human NCI-H1963 cell growth in a cell viability assay, IC50=1.27839 μM	SANGER
NCI-H2081	-	Growth inhibition assay	-	Inhibition of human NCI-H2081 cell growth in a cell viability assay, IC50=34.6044 μM	SANGER
NCI-H209	-	Growth inhibition assay	-	Inhibition of human NCI-H209 cell growth in a cell viability assay, IC50=22.6272 μM	SANGER
NCI-H2107	-	Growth inhibition assay	-	Inhibition of human NCI-H2107 cell growth in a cell viability assay, IC50=25.6561 μM	SANGER
NCI-H2126	-	Growth inhibition assay	-	Inhibition of human NCI-H2126 cell growth in a cell viability assay, IC50=6.50426 μM	SANGER
NCI-H2171	-	Growth inhibition assay	-	Inhibition of human NCI-H2171 cell growth in a cell viability assay, IC50=0.95937 μM	SANGER
NCI-H2227	-	Growth inhibition assay	-	Inhibition of human NCI-H2227 cell growth in a cell viability assay, IC50=7.88616 μM	SANGER
NCI-H524	-	Growth inhibition assay	-	Inhibition of human NCI-H524 cell growth in a cell viability assay, IC50=22.8763 μM	SANGER
NCI-H526	-	Growth inhibition assay	-	Inhibition of human NCI-H526 cell growth in a cell viability assay, IC50=18.5431 μM	SANGER
NCI-H720	-	Growth inhibition assay	-	Inhibition of human NCI-H720 cell growth in a cell viability assay, IC50=2.45161 μM	SANGER
NMC-G1	-	Growth inhibition assay	-	Inhibition of human NMC-G1 cell growth in a cell viability assay, IC50=15.0578 μM	SANGER
no-10 cell	-	Growth inhibition assay	-	Inhibition of human no-10 cell growth in a cell viability assay, IC50=0.66846 μM	SANGER
no-11 cell	-	Growth inhibition assay	-	Inhibition of human no-11 cell growth in a cell viability assay, IC50=47.0263 μM	SANGER
NOS-1 cell	-	Growth inhibition assay	-	Inhibition of human NOS-1 cell growth in a cell viability assay, IC50=5.82294 μM	SANGER
NTERA-S-cl-D1 cell	-	Growth inhibition assay	-	Inhibition of human NTERA-S-cl-D1 cell growth in a cell viability assay, IC50=12.8935 μM	SANGER
OCI-AML2 cell	-	Growth inhibition assay	-	Inhibition of human OCI-AML2 cell growth in a cell viability assay, IC50=10.9496 μM	SANGER
OCUB-M cell	-	Growth inhibition assay	-	Inhibition of human OCUB-M cell growth in a cell viability assay, IC50=17.201 μM	SANGER
ONS-76 cell	-	Growth inhibition assay	-	Inhibition of human ONS-76 cell growth in a cell viability assay, IC50=13.9191 μM	SANGER
OS-RC-2 cell	-	Growth inhibition assay	-	Inhibition of human OS-RC-2 cell growth in a cell viability assay, IC50=46.195 μM	SANGER
OVCAR-4 cell	-	Growth inhibition assay	-	Inhibition of human OVCAR-4 cell growth in a cell viability assay, IC50=8.71808 μM	SANGER
P30-OHK cell	-	Growth inhibition assay	-	Inhibition of human P30-OHK cell growth in a cell viability assay, IC50=7.62877 μM	SANGER
P30-OHK cell	-	Growth inhibition assay	-	Inhibition of human PF-382 cell growth in a cell viability assay, IC50=7.04954 μM	SANGER
PSN1 cell	-	Growth inhibition assay	-	Inhibition of human PSN1 cell growth in a cell viability assay, IC50=6.22126 μM	SANGER
QIMR-WIL cell	-	Growth inhibition assay	-	Inhibition of human QIMR-WIL cell growth in a cell viability assay, IC50=0.49004 μM	SANGER
Ramos-2G6-4C10 cell	-	Growth inhibition assay	-	Inhibition of human Ramos-2G6-4C10 cell growth in a cell viability assay, IC50=1.357 μM	SANGER
RCC10RGB cell	-	Growth inhibition assay	-	Inhibition of human RCC10RGB cell growth in a cell viability assay, IC50=18.9036 μM	SANGER
RKO cell	-	Growth inhibition assay	-	Inhibition of human RKO cell growth in a cell viability assay, IC50=10.5662 μM	SANGER
RL95-2 cell	-	Growth inhibition assay	-	Inhibition of human RL95-2 cell growth in a cell viability assay, IC50=10.67 μM	SANGER
RPMI-6666 cell	-	Growth inhibition assay	-	Inhibition of human RPMI-6666 cell growth in a cell viability assay, IC50=18.5236 μM	SANGER
RPMI-8402 cell	-	Growth inhibition assay	-	Inhibition of human RPMI-8402 cell growth in a cell viability assay, IC50=4.5856 μM	SANGER
RXF393 cell	-	Growth inhibition assay	-	Inhibition of human RXF393 cell growth in a cell viability assay, IC50=0.393 μM	SANGER
SCLC-21H cell	-	Growth inhibition assay	-	Inhibition of human SCLC-21H cell growth in a cell viability assay, IC50=7.61149 μM	SANGER
SF126 cell	-	Growth inhibition assay	-	Inhibition of human SF126 cell growth in a cell viability assay, IC50=11.8321μM	SANGER
SF268 cell	-	Growth inhibition assay	-	Inhibition of human SF268 cell growth in a cell viability assay, IC50=6.23183 μM	SANGER
SF539 cell	-	Growth inhibition assay	-	Inhibition of human SF539 cell growth in a cell viability assay, IC50=1.28661 μM	SANGER
SH-4 cell	-	Growth inhibition assay	-	Inhibition of human SH-4 cell growth in a cell viability assay, IC50=5.75508 μM	SANGER
SIG-M5 cell	-	Growth inhibition assay	-	Inhibition of human SIG-M5 cell growth in a cell viability assay, IC50=11.7259 μM	SANGER
SJSA-1 cell	-	Growth inhibition assay	-	Inhibition of human SJSA-1 cell growth in a cell viability assay, IC50=1.04526 μM	SANGER
SK-LMS-1 cell	-	Growth inhibition assay	-	Inhibition of human SK-LMS-1 cell growth in a cell viability assay, IC50=32.5965 μM	SANGER
SK-MM-2 cell	-	Growth inhibition assay	-	Inhibition of human SK-MM-2 cell growth in a cell viability assay, IC50=42.3405 μM	SANGER
SK-N-DZ cell	-	Growth inhibition assay	-	Inhibition of human SK-N-DZ cell growth in a cell viability assay, IC50=9.48314 μM	SANGER
SK-NEP-1 cell	-	Growth inhibition assay	-	Inhibition of human SK-NEP-1 cell growth in a cell viability assay, IC50=17.5456 μM	SANGER
SK-PN-DW cell	-	Growth inhibition assay	-	Inhibition of human SK-PN-DW cell growth in a cell viability assay, IC50=24.9736 μM	SANGER
SNB75 cell	-	Growth inhibition assay	-	Inhibition of human SNB75 cell growth in a cell viability assay, IC50=8.07737 μM	SANGER
SR cell	-	Growth inhibition assay	-	Inhibition of human SR cell growth in a cell viability assay, IC50=0.000137 μM	SANGER
SU-DHL-1 cell	-	Growth inhibition assay	-	Inhibition of human SU-DHL-1 cell growth in a cell viability assay, IC50=12.7336 μM	SANGER
SW684 cell	-	Growth inhibition assay	-	Inhibition of human SW684 cell growth in a cell viability assay, IC50=39.011 μM	SANGER
SW872 cell	-	Growth inhibition assay	-	Inhibition of human SW872 cell growth in a cell viability assay, IC50=0.88656 μM	SANGER
SW962 cell	-	Growth inhibition assay	-	Inhibition of human SW962 cell growth in a cell viability assay, IC50=12.7521 μM	SANGER
TE-10 cell	-	Growth inhibition assay	-	Inhibition of human TE-10 cell growth in a cell viability assay, IC50=22.8423 μM	SANGER
TE-12 cell	-	Growth inhibition assay	-	Inhibition of human TE-12 cell growth in a cell viability assay, IC50=32.4114 μM	SANGER
TE-8 cell	-	Growth inhibition assay	-	Inhibition of human TE-8 cell growth in a cell viability assay, IC50=11.6089 μM	SANGER
TE-9 cell	-	Growth inhibition assay	-	Inhibition of human TE-9 cell growth in a cell viability assay, IC50=36.6381 μM	SANGER
TGW cell	-	Growth inhibition assay	-	Inhibition of human TGW cell growth in a cell viability assay, IC50=23.3577 μM	SANGER
UACC-257 cell	-	Growth inhibition assay	-	Inhibition of human UACC-257 cell growth in a cell viability assay, IC50=8.70625 μM	SANGER
WSU-NHL cell	-	Growth inhibition assay	-	Inhibition of human WSU-NHL cell growth in a cell viability assay, IC50=27.1907 μM	SANGER

靶点	Description	IC50
ROCK1		IC50:1.6nM
ROCK2		IC50:4nM

GSK269962A HCl Catalog No. CSN19208

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