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CAS No.: 1227911-45-6
Synonyms: GSK2334470
GSK2334470 is a PDK1 inhibitor with IC50 of ~10 nM, with no activity at other close related AGC-kinases.
生物活性
靶点 | PDK-1 IC50:~10nM |
实验方案
技术信息
CAS号 | 1227911-45-6 | 储存条件 |
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分子式 | C25H34N8O | 运输 | 蓝冰 | |||||||
分子量 | 462.59 | 别名 | GSK2334470 | |||||||
溶解度 |
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动物实验配方 |
Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
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F-36P cells | - | Proliferation assay | - | Antiproliferative activity against human F-36P cells, IC50=0.28 μM | 21341675 |
insect cells | - | Function assay | - | Inhibition of recombinant full length PDK1 (unknown origin) expressed in insect cells assessed as inhibition of Akt activation measured for 30 mins in presence of [gamma32P-ATP], IC50=0.01 μM | 23448267 |
K562 cells | - | Proliferation assay | - | Antiproliferative activity against human K562 cells, IC50=18 μM | 21341675 |
OCI-AML2 cells | - | Proliferation assay | - | Antiproliferative activity against human OCI-AML2 cells, IC50=0.35 μM | 21341675 |
OCI-AML3 cells | - | Proliferation assay | - | Antiproliferative activity against human OCI-AML3 cells, IC50=0.52 μM | 21341675 |
PC3 cells | - | Function assay | - | Inhibition of PDK1-mediated AKT phosphorylation at Thr308 residue in human PC3 cells by ELISA, IC50=0.113 μM | 21341675 |
PC3 cells | - | Function assay | - | Inhibition of PDK1-mediated RSK phosphorylation at Ser221 residue in human PC3 cells by ELISA, IC50=0.293 μM | 21341675 |
靶点 | Description | IC50 |
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PDK-1 | IC50:~10nM |
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