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CAS No.: 732279-26-4

棉酚x醋酸盐 Catalog No. CSN11115

Synonyms: Pogosin;AT-101;(±)-Gossypol-acetic Acid

Gossypol-acetic acid, a polyphenolic compound isolated from the seeds of Gossypium herbaceum L., inhibits Bcl-2 by acting as a BH3 mimetic.

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实验方案

技术信息

生物活性

描述Gossypol-acetic acid, a polyphenolic compound isolated from the seeds of Gossypium herbaceum L., inhibits Bcl-2 by acting as a BH3 mimetic.
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02938520	HIV Infections	Phase 2 Phase 3	Active, not recruiting	July 7, 2022	-
NCT01315444	Condition Measuring Alkaline T... more >>ide and Filling Symptoms' Questionnaire After Abrupt or Gradual Step Down Cessation of PPI Collapse <<	Phase 1	Withdrawn	-	-
NCT00244374	Medication Adherence ... more >> Substance Abuse, Intravenous Risk Behavior Hepatitis A Hepatitis B Hepatitis C Collapse <<	Not Applicable	Completed	-	United States, California ... more >> University of California San Francisco Medical Cen San Francisco, California, United States, 94143 0939 Collapse <<

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参考文献

[1] Lin J, Wu Y, et al. Induction of apoptosis and antitumor effects of a small molecule inhibitor of Bcl-2 and Bcl-xl, gossypol acetate, in multiple myeloma in vitro and in vivo. Oncol Rep. 2013 Aug;30(2):731-8.
[2] Ciereszko A, Dabrowski K. In vitro effect of gossypol acetate on yellow perch (Perca flavescens) spermatozoa. Aquat Toxicol. 2000 Jun 1;49(3):181-187.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.7283 mL
- 8.6415 mL
- 17.2829 mL
- 5 mM
- 0.3457 mL
- 1.7283 mL
- 3.4566 mL
- 10 mM
- 0.1728 mL
- 0.8641 mL
- 1.7283 mL

技术信息

CAS号

732279-26-4

储存条件

粉末: Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C32H34O10

运输

蓝冰

分子量

578.61

别名

Pogosin;AT-101;(±)-Gossypol-acetic Acid;Gossypol Acetic Acid

溶解度

DMSO	100.0 mg/mL (172.8 mM)
Water	insoluble

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02938520	HIV Infections	Phase 2 Phase 3	Active, not recruiting	July 7, 2022	-
NCT01315444	Condition Measuring Alkaline T... more >>ide and Filling Symptoms' Questionnaire After Abrupt or Gradual Step Down Cessation of PPI Collapse <<	Phase 1	Withdrawn	-	-
NCT00244374	Medication Adherence ... more >> Substance Abuse, Intravenous Risk Behavior Hepatitis A Hepatitis B Hepatitis C Collapse <<	Not Applicable	Completed	-	United States, California ... more >> University of California San Francisco Medical Cen San Francisco, California, United States, 94143 0939 Collapse <<
NCT00390403	Brain and Central Nervous Syst... more >>em Tumors Collapse <<	Phase 1	Completed	-	United States, Alabama ... more >> Lurleen Wallace Comprehensive Cancer at University of Alabama - Birmingham Birmingham, Alabama, United States, 35294 United States, Florida H. Lee Moffitt Cancer Center and Research Institute at University of South Florida Tampa, Florida, United States, 33612-9497 United States, Georgia Winship Cancer Institute of Emory University Atlanta, Georgia, United States, 30322 United States, Maryland Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Baltimore, Maryland, United States, 21231-2410 United States, Michigan Josephine Ford Cancer Center at Henry Ford Hospital Detroit, Michigan, United States, 48202 United States, North Carolina Wake Forest University Comprehensive Cancer Center Winston-Salem, North Carolina, United States, 27157-1096 United States, Ohio Cleveland Clinic Taussig Cancer Center Cleveland, Ohio, United States, 44195 United States, Pennsylvania Abramson Cancer Center of the University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104-4283 Collapse <<
NCT00244374	-	-	Completed	-	-
NCT00891072	Adult Grade III Lymphomatoid G... more >>ranulomatosis Adult Nasal Type Extranodal NK/T-cell Lymphoma Contiguous Stage II Adult Burkitt Lymphoma Contiguous Stage II Adult Diffuse Large Cell Lymphoma Contiguous Stage II Adult Diffuse Mixed Cell Lymphoma Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma Contiguous Stage II Adult Immunoblastic Large Cell Lymphoma Contiguous Stage II Adult Lymphoblastic Lymphoma Contiguous Stage II Grade 1 Follicular Lymphoma Contiguous Stage II Grade 2 Follicular Lymphoma Contiguous Stage II Grade 3 Follicular Lymphoma Contiguous Stage II Mantle Cell Lymphoma Contiguous Stage II Marginal Zone Lymphoma Contiguous Stage II Small Lymphocytic Lymphoma Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue Nodal Marginal Zone B-cell Lymphoma Noncontiguous Stage II Adult Burkitt Lymphoma Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma Noncontiguous Stage II Adult Lymphoblastic Lymphoma Noncontiguous Stage II Grade 1 Follicular Lymphoma Noncontiguous Stage II Grade 2 Follicular Lymphoma Noncontiguous Stage II Grade 3 Follicular Lymphoma Noncontiguous Stage II Mantle Cell Lymphoma Noncontiguous Stage II Marginal Zone Lymphoma Noncontiguous Stage II Small Lymphocytic Lymphoma Peripheral T-cell Lymphoma Recurrent Adult Burkitt Lymphoma Recurrent Adult Diffuse Large Cell Lymphoma Recurrent Adult Diffuse Mixed Cell Lymphoma Recurrent Adult Diffuse Small Cleaved Cell Lymphoma Recurrent Adult Grade III Lymphomatoid Granulomatosis Recurrent Adult Immunoblastic Large Cell Lymphoma Recurrent Adult Lymphoblastic Lymphoma Recurrent Grade 1 Follicular Lymphoma Recurrent Grade 2 Follicular Lymphoma Recurrent Grade 3 Follicular Lymphoma Recurrent Mantle Cell Lymphoma Recurrent Marginal Zone Lymphoma Recurrent Small Lymphocytic Lymphoma Splenic Marginal Zone Lymphoma Stage I Adult Burkitt Lymphoma Stage I Adult Diffuse Large Cell Lymphoma Stage I Adult Diffuse Mixed Cell Lymphoma Stage I Adult Diffuse Small Cleaved Cell Lymphoma Stage I Adult Immunoblastic Large Cell Lymphoma Stage I Adult Lymphoblastic Lymphoma Stage I Grade 1 Follicular Lymphoma Stage I Grade 2 Follicular Lymphoma Stage I Grade 3 Follicular Lymphoma Stage I Mantle Cell Lymphoma Stage I Marginal Zone Lymphoma Stage I Small Lymphocytic Lymphoma Stage III Adult Burkitt Lymphoma Stage III Adult Diffuse Large Cell Lymphoma Stage III Adult Diffuse Mixed Cell Lymphoma Stage III Adult Diffuse Small Cleaved Cell Lymphoma Stage III Adult Immunoblastic Large Cell Lymphoma Stage III Adult Lymphoblastic Lymphoma Stage III Grade 1 Follicular Lymphoma Stage III Grade 2 Follicular Lymphoma Stage III Grade 3 Follicular Lymphoma Stage III Mantle Cell Lymphoma Stage III Marginal Zone Lymphoma Stage III Small Lymphocytic Lymphoma Stage IV Adult Burkitt Lymphoma Stage IV Adult Diffuse Large Cell Lymphoma Stage IV Adult Diffuse Mixed Cell Lymphoma Stage IV Adult Diffuse Small Cleaved Cell Lymphoma Stage IV Adult Immunoblastic Large Cell Lymphoma Stage IV Adult Lymphoblastic Lymphoma Stage IV Grade 1 Follicular Lymphoma Stage IV Grade 2 Follicular Lymphoma Stage IV Grade 3 Follicular Lymphoma Stage IV Mantle Cell Lymphoma Stage IV Marginal Zone Lymphoma Stage IV Small Lymphocytic Lymphoma Unspecified Adult Solid Tumor, Protocol Specific Waldenström Macroglobulinemia Collapse <<	Phase 1	Completed	-	United States, New Jersey ... more >> Cancer Institute of New Jersey New Brunswick, New Jersey, United States, 08903 Collapse <<
NCT00286806	Hormone Refractory Prostate Ca... more >>ncer Collapse <<	Phase 1 Phase 2	Completed	-	United States, California ... more >> Greenbrae, California, United States United States, Connecticut New Haven, Connecticut, United States United States, Tennessee Memphis, Tennessee, United States United States, Wisconsin Madison, Wisconsin, United States Collapse <<
NCT03685084	Healthy	Phase 1	Completed	-	-
NCT01633541	Laryngeal Cancer	Phase 2	Active, not recruiting	December 2018	United States, Michigan ... more >> University of Michigan Comprehensive Cancer Center Ann Arbor, Michigan, United States, 48109 Collapse <<
NCT00275431	Follicular Lymphoma ... more >> Diffuse Large Cell Lymphoma Mantle Cell Lymphoma Small Lymphocytic Lymphoma Chronic Lymphocytic Leukemia Collapse <<	Phase 2	Completed	-	United States, Alabama ... more >> Birmingham, Alabama, United States United States, California San Diego, California, United States United States, Georgia Atlanta, Georgia, United States United States, Illinois Chicago, Illinois, United States United States, Massachusetts Boston, Massachusetts, United States United States, New York New York, New York, United States Rochester, New York, United States United States, North Carolina High Point, North Carolina, United States United States, South Carolina Hilton Head Island, South Carolina, United States United States, Tennessee Memphis, Tennessee, United States United States, Vermont Burlington, Vermont, United States Collapse <<
NCT01265199	Acute Myelogenous Leukemia (AM... more >>L) Collapse <<	Phase 1	Terminated(Study was terminate... more >>d before a MTD was determined for administrative reasons) Collapse <<	-	United States, Illinois ... more >> Univerity of Chicago Chicago, Illinois, United States United States, Michigan University of Michigan Health System Ann Arbor, Michigan, United States United States, Missouri Washington University at St. Louis Siteman Cancer Center St. Louis, Missouri, United States United States, New York Memorial Sloan Kettering Cancer Center New York, New York, United States United States, Pennsylvania Hospital of the University of Pennsylvania Philadelphia, Pennsylvania, United States Temple University at Jeanes Hospital Philadelphia, Pennsylvania, United States Collapse <<
NCT00440388	Follicular Lymphoma	Phase 2	Completed	-	-
NCT01285635	Squamous Cell Carcinoma of the... more >> Head and Neck (SCCHN) Collapse <<	Phase 2	Terminated(drug is no longer m... more >>anufactured) Collapse <<	-	United States, Michigan ... more >> University of Michigan Comprehensive Cancer Center Ann Arbor, Michigan, United States, 48109 Barbara Ann Karmanos Cancer Institute Detroit, Michigan, United States, 48201 Collapse <<
NCT00397293	Small Cell Lung Cancer	Phase 1 Phase 2	Completed	-	-
NCT00571675	Hormone Refractory Prostate Ca... more >>ncer Collapse <<	Phase 2	Completed	-	-
NCT00544960	Non-small Cell Lung Cancer	Phase 2	Completed	-	United States, North Carolina ... more >> Research Site Durham, North Carolina, United States Russian Federation Research Site Arkhangelsk, Russian Federation Research Site Chelyabinsk, Russian Federation Research Site Ekaterinburg, Russian Federation Research Site Kaliningrad, Russian Federation Research Site Kazan, Russian Federation Research Site Moscow, Russian Federation Research Sites (4) Saint Petersburg, Russian Federation Research Site Samara, Russian Federation Research Site Stavropol, Russian Federation Research Site Voronezh, Russian Federation Ukraine Research Site Dnipropetrovsk, Ukraine Research Site Donetsk, Ukraine Research Site Kharkiv, Ukraine Research Site Kyiv, Ukraine Research Site Lugansk, Ukraine Research Site Uzhgorod, Ukraine Research Site Zaporizhzhya, Ukraine Collapse <<
NCT00666666	-	-	Completed	-	-
NCT00666666	Adenocarcinoma of the Prostate... more >> Stage IV Prostate Cancer Collapse <<	Phase 2	Completed	-	United States, Illinois ... more >> University of Chicago Chicago, Illinois, United States, 60637 United States, Michigan University of Michigan Ann Arbor, Michigan, United States, 48109 United States, New Jersey Cancer Institute of New Jersey New Brunswick, New Jersey, United States, 08903 United States, Wisconsin University of Wisconsin Hospital and Clinics Madison, Wisconsin, United States, 53792 Collapse <<
NCT02697344	Recurrent Plasma Cell Myeloma	Phase 1 Phase 2	Suspended(per study design to ... more >>temporarily close) Collapse <<	June 15, 2021	United States, Florida ... more >> Mayo Clinic in Florida Jacksonville, Florida, United States, 32224-9980 Collapse <<
NCT00773955	Extensive Stage Small Cell Lun... more >>g Cancer Recurrent Small Cell Lung Cancer Collapse <<	Phase 2	Completed	-	United States, Minnesota ... more >> Mayo Clinic Rochester, Minnesota, United States, 55905 Collapse <<
NCT00773955	-	-	Completed	-	-
NCT00544596	Extensive Stage Small Cell Lun... more >>g Cancer Unspecified Adult Solid Tumor, Protocol Specific Collapse <<	Phase 1	Completed	-	United States, South Dakota ... more >> Sanford Cancer Center-Oncology Clinic Sioux Falls, South Dakota, United States, 57104 United States, Wisconsin Gundersen Lutheran La Crosse, Wisconsin, United States, 54601 UW Health Oncology - 1 South Park Madison, Wisconsin, United States, 53715 University of Wisconsin Hospital and Clinics Madison, Wisconsin, United States, 53792 Collapse <<
NCT01003769	Recurrent Chronic Lymphocytic ... more >>Leukemia Collapse <<	Phase 1 Phase 2	Suspended(The accrual objectiv... more >>e for this study has not been met and is currently being re-prioritized until beacon validation sessions are completed.) Collapse <<	June 2020	United States, Florida ... more >> Mayo Clinic in Florida Jacksonville, Florida, United States, 32224-9980 United States, New York Roswell Park Cancer Institute Buffalo, New York, United States, 14263 Collapse <<
NCT00540722	Adult Giant Cell Glioblastoma ... more >> Adult Glioblastoma Adult Gliosarcoma Recurrent Adult Brain Tumor Collapse <<	Phase 2	Completed	-	United States, Alabama ... more >> University of Alabama at Birmingham Birmingham, Alabama, United States, 35294 United States, Florida Moffitt Cancer Center Tampa, Florida, United States, 33612 United States, Maryland Johns Hopkins University Baltimore, Maryland, United States, 21287 United States, Massachusetts Massachusetts General Hospital Boston, Massachusetts, United States, 02114 United States, Michigan Henry Ford Hospital Detroit, Michigan, United States, 48202 United States, North Carolina Wake Forest University Health Sciences Winston-Salem, North Carolina, United States, 27157 United States, Ohio Cleveland Clinic Foundation Cleveland, Ohio, United States, 44195 United States, Pennsylvania University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 Collapse <<
NCT00540722	-	-	Completed	-	-
NCT00561197	Locally Advanced Esophageal or... more >> GE Junction Cancer Collapse <<	Phase 1 Phase 2	Terminated(Drug not being deve... more >>loped for this indication) Collapse <<	-	United States, Texas ... more >> MD Anderson Cancer Center Houston, Texas, United States Collapse <<
NCT00286780	Chronic Lymphocytic Leukemia	Phase 2	Completed	-	United States, California ... more >> UCSD Moores Cancer Center San Diego, California, United States, 92093 Collapse <<
NCT00988169	-	-	Terminated	-	-
NCT01977209	Non-small Cell Lung Cancer	Phase 3	Unknown	September 2016	China, Chongqing ... more >> Daping Hospital, Third Military Medical University Recruiting Chongqing, Chongqing, China, 400042 Contact: Dong Wang, PH.D. 86-23-68757151 dongwang64@hotmail.com Principal Investigator: Dong Wang, PH.D. Chongqing Zhongshan Hospital Recruiting Chongqing, Chongqing, China Contact: Zhixiang Yang, M.D. 13032372491 Principal Investigator: Zhixiang Yang Fuling Central Hospital Recruiting Chongqing, Chongqing, China Contact: Qi Zhou, M.D. 86-23-7222676 Principal Investigator: Qi Zhou, M.D. Jiangjin Central Hospital Recruiting Chongqing, Chongqing, China Contact: Debing Xiang, M.D. 86-13320336639 Principal Investigator: Debing Xiang, M.D. The Second Affiliated Hospital of Medical University Of Chongqing Recruiting Chongqing, Chongqing, China Contact: Xianquan Zhang, M.D. 86-23-63693000 Principal Investigator: Xianquan Zhang, M.D. Three Gorges Central Hospital Recruiting Chongqing, Chongqing, China Contact: Biyong Ren 13896327099 Principal Investigator: Biyong Ren, M.D. Collapse <<
NCT00286793	Prostate Cancer	Phase 1 Phase 2	Completed	-	United States, Arkansas ... more >> Hot Springs, Arkansas, United States United States, Florida Fort Meyers, Florida, United States United States, Illinois Chicago, Illinois, United States United States, Minnesota Fridley, Minnesota, United States United States, New Mexico Albuquerque, New Mexico, United States United States, New York Syracuse, New York, United States United States, North Carolina Wilmington, North Carolina, United States United States, Oregon Portland, Oregon, United States United States, South Carolina Hilton Head Island, South Carolina, United States United States, Tennessee Germantown, Tennessee, United States Memphis, Tennessee, United States Nashville, Tennessee, United States United States, Texas Richardson, Texas, United States Collapse <<
NCT00848016	Recurrent Adrenocortical Carci... more >>noma Stage III Adrenocortical Carcinoma Stage IV Adrenocortical Carcinoma Collapse <<	Phase 2	Completed	-	United States, California ... more >> University of Southern California Los Angeles, California, United States, 90033-0804 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 Collapse <<
NCT00848016	-	-	Completed	-	-
NCT01285635	-	-	Terminated(drug is no longer m... more >>anufactured) Collapse <<	-	-
NCT00934076	Carcinoma, Non Small Cell Lung	Phase 1	Withdrawn(Study was never acti... more >>vated) Collapse <<	June 2015	-
NCT00988169	Lung Cancer	Phase 2	Terminated	-	United States, New York ... more >> Memorial Sloan Kettering Cancer Center New York, New York, United States, 10021 Collapse <<

棉酚x醋酸盐 Catalog No. CSN11115

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