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CAS No.: 40957-83-3

Glycitein/黄豆黄素 Catalog No. CSN12353

Synonyms: Glycetein;Q-100465;黄豆黄素

Glycitein, a soybean isoflavonoid with anti-oxidation, can induce the expression of antioxidant genes like antioxidant response element (ARE). It is also used in the study of apoptosis when combination with other isoflavonoids such as genistein and daidzein.

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生物活性

描述Glycitein, as one of the three major isoflavones in soybeans, directly but significantly (about 5%) suppressed the proliferation of MC3T3-E1 and stimulated bone-related protein (alkaline phosphatase (ALP) and osteocalcin (OC)) expression^[3]. Glycitein has weak estrogenic activity, comparable to that of the other soy isoflavones but much lower than that of DES and 17beta-estradiol^[4]. Glycitein exhibits biphasic regulation on SKBR-3 cells. At concentrations of less than 10 mg/mL, cells respond to glycitein by increasing cell growth and de novo DNA synthesis whereas the addition of glycitein at concentrations greater than 30 mg/mL significantly inhibited cell growth and DNA synthesis in a dose-dependent manner. Glycitein was found to be cytostatic at low concentrations and cytotoxic at higher concentrations. Treatment with 100 mg/mL of glycitein severely altered the cell morphology^[5]. Osteoclast generation was inhibited by glycitein in a biphasic-dose-dependent manner and showed the greatest inhibitory effects at 10 nM. Glycitein increased caspase 3/7 activity by 15% at a concentration of 10 nM. Further, 10 nM glycitein significantly decreased the expression of IL-6 and RANKL in osteoblasts but did not change mRNA levels of OPG(osteoprotegerin) ^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01232751	Postmenopause	Not Applicable	Completed	-	Netherlands ... more >> Wageningen University Wageningen, Gelderland, Netherlands, 6703 HD Collapse <<
NCT03008785	Bloodpressure	Not Applicable	Completed	-	Brazil ... more >> Guilherme Morais Puga Uberlandia, Minas Gerais, Brazil, 38400-678 Collapse <<
NCT01048606	Overweight	Phase 4	Completed	-	Canada, Quebec ... more >> Centre de recherche sur le vieillissement du CSSS-IUGS Sherbrooke, Quebec, Canada, J1H 4C4 Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.5179 mL
- 17.5893 mL
- 35.1786 mL
- 5 mM
- 0.7036 mL
- 3.5179 mL
- 7.0357 mL
- 10 mM
- 0.3518 mL
- 1.7589 mL
- 3.5179 mL

技术信息

CAS号

40957-83-3

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C16H12O5

运输

蓝冰

分子量

284.26

别名

Glycetein;Q-100465;黄豆黄素

溶解度

DMSO	56.0 mg/mL (197.0 mM)

动物实验配方

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