CAS No.: 59870-68-7
Glabridin/光甘草定 Catalog No. CSN11100
Synonyms: Q-100692;KB-289522;LS-176045
Glabridin has many biological functions such as regulating the synthesis and activity of iNOS under high-glucose levels, significantly inhibiting free radicals generated during metabolism in the body, and protecting against oxidation-sensitive biomacromolecules (LDL, LDL, DNA) and cell walls. It is a natural product isolated and purified from the roots of Glycyrrhiza glabra L. with whitening and anti-aging activity.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Yehuda I, Madar Z, et al. Glabridin, an isoflavan from licorice root, downregulates iNOS expression and activity under high-glucose stress and inflammation. Mol Nutr Food Res. 2015 Jun;59(6):1041-52.
- [2] Hsieh MJ, Lin CW, et al. Glabridin inhibits migration and invasion by transcriptional inhibition of matrix metalloproteinase 9 through modulation of NF-κB and AP-1 activity in human liver cancer cells. Br J Pharmacol. 2014 Jun;171(12):3037-50.
- [3] Hespeler D, Kaltenbach J, Pyo SM. Glabridin smartPearls - Silica selection, production, amorphous stability and enhanced solubility. Int J Pharm. 2019 Apr 20;561:228-235. doi: 10.1016/j.ijpharm.2019.02.028. Epub 2019 Mar 2. PMID: 30836152.
- [4] Li LJ, Li GW, Xie Y. Zhongguo Zhong Yao Za Zhi. 2019;44(17):3786-3791.
- [5] Mu J, Zhu D, Shen Z, Ning S, Liu Y, Chen J, Li Y, Li Z. The repressive effect of miR-148a on Wnt/β-catenin signaling involved in Glabridin-induced anti-angiogenesis in human breast cancer cells. BMC Cancer. 2017 May 2;17(1):307. doi: 10.1186/s12885-017-3298-1. PMID: 28464803; PMCID: PMC5414299.
- [6] Hsieh MJ, Lin CW, Yang SF, Chen MK, Chiou HL. Glabridin inhibits migration and invasion by transcriptional inhibition of matrix metalloproteinase 9 through modulation of NF-κB and AP-1 activity in human liver cancer cells. Br J Pharmacol. 2014 Jun;171(12):3037-50. doi: 10.1111/bph.12626. Erratum in: Br J Pharmacol. 2017 May;174(9):909-910. PMID: 24641665; PMCID: PMC4055204.
- [7] Huang HL, Hsieh MJ, Chien MH, Chen HY, Yang SF, Hsiao PC. Glabridin mediate caspases activation and induces apoptosis through JNK1/2 and p38 MAPK pathway in human promyelocytic leukemia cells. PLoS One. 2014 Jun 5;9(6):e98943. doi: 10.1371/journal.pone.0098943. PMID: 24901249; PMCID: PMC4047044.
- [8] Kwon HS, Oh SM, Kim JK. Glabridin, a functional compound of liquorice, attenuates colonic inflammation in mice with dextran sulphate sodium-induced colitis. Clin Exp Immunol. 2008 Jan;151(1):165-73. doi: 10.1111/j.1365-2249.2007.03539.x. Epub 2007 Nov 14. PMID: 18005263; PMCID: PMC2276918.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 59870-68-7 | 储存条件 |
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| 分子式 | C20H20O4 | 运输 | 蓝冰 | |||||
| 分子量 | 324.37 | 别名 | Q-100692;KB-289522;LS-176045;光甘草定 | |||||
| 溶解度 |
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动物实验配方 |
