生物活性

• 描述Givinostat hydrochloride is a potent HDAC inhibitor for Maize HD2, HD1-B and HD1-A with IC50 of 10 nM, 7.5 nM and 16 nM, respectively.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT01761968	Chronic Myeloproliferative Neo... more >>plasms Collapse <<	Phase 2	Recruiting	December 2020	France ... more >> Hopital Saint Vincent de Paul - GHICL Lille Recruiting Lille, Lille Cedex, France, 59020 Contact: Laurent Pascal, MD    +33320874532    pascal.laurent@ghicl.net    Principal Investigator: Laurent Pascal, MD          Germany Charite Research Organization GmbH Recruiting Berlin, Germany, 10117 Contact: Antonio Pezzutto, Prof.       antonio.pezzutto@charite.de    Principal Investigator: Antonio Pezzutto, Prof.          Universitaetsklinikum Freiburg, Innere Medizin I - Haematologie und Onkologie Recruiting Freiburg, Germany, 79106 Contact: Nikolas von Bubnoff, MD       nikolas.bubnoff@uniklinik-freiburg.de    Principal Investigator: Nikolas von Bubnoff, MD          Italy Azienda Ospedaliero-Universitaria Policlinico Consorziale, Bari Recruiting Bari, BA, Italy, 70124 Contact: Giorgina Specchia, MD          Principal Investigator: Giorgina Specchia, MD          Istituto Tumori Giovanni Paolo II IRCCS Ospedale Oncologico di Bari Recruiting Bari, BA, Italy, 70125 Contact: Attilio Guarini, MD       attilioguarini@oncologico.bari.it    Azienda Ospedaliera Papa Giovanni XXIII Recruiting Bergamo, BG, Italy, 24127 Contact: Alessandro Rambaldi, MD       arambaldi@hpg23.it    Principal Investigator: Alessandro Rambaldi, MD          Azienda Ospedaliero-Universitaria Careggi, Florence Recruiting Florence, FI, Italy, 50134 Contact: Alessandro M Vannucchi, MD          Principal Investigator: Alessandro M Vannucchi, MD          Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico UOS Oncoematologia anziano Recruiting Milan, MI, Italy, 20122 Contact: Alessandra Iurlo, Prof       aiurlo@policlinico.mi.it    Azienda Unità Sanitaria Locale - Presidio Ospedaliero "Spirito Santo", Pescara Recruiting Pescara, PE, Italy, 65124 Contact: Paolo Di Bartolomeo, MD          Principal Investigator: Paolo Di Bartolomeo, MD          Fondazione I.R.C.C.S.-Policlinico San Matteo, Pavia Recruiting Pavia, PV, Italy, 27100 Contact: Vittorio Rosti, MD          Principal Investigator: Vittorio Rosti, MD          Azienda Ospedaliera "Bianchi-Melacrino-Morelli" Recruiting Reggio Calabria, RC, Italy, 89125 Contact: Bruno Martino, MD          Principal Investigator: Bruno Martino, MD          Ospedale San Bortolo, Vicenza Recruiting Vicenza, VI, Italy, 36100 Contact: Marco Ruggeri, MD          Principal Investigator: Marco Ruggeri, MD          Azienda Ospedaliera Universitaria Università degli Studi "Federico II", Naple Recruiting Naples, Italy, 80131 Contact: Vincenzo Martinelli, MD          Principal Investigator: Vincenzo Martinelli, MD          Università "Campus Bio-Medico", Rome Recruiting Rome, Italy, 00128 Contact: Giuseppe Avvisati, MD          Principal Investigator: Giuseppe Avvisati, MD          United Kingdom Belfast City Hospital Recruiting Belfast, United Kingdom, BT9 7BL Contact: Mary Frances McMullin, MD       m.mcmullin@qub.ac.uk    Principal Investigator: Mary Frances McMullin, MD          Royal Cornwall Hospital Recruiting Truro, United Kingdom, TR1 3LJ Contact: Richard Noble, MD       richard.noble@rcht.cornwall.nhs.uk    Principal Investigator: Richard Noble, MD Collapse <<
  NCT01901432	Polycythemia Vera	Phase 1 Phase 2	Completed	-	France ... more >> CHU Amiens - Hôpital Sud Amiens Cedex 1, France, 80054 Hôpital Morvan - CHRU de Brest Brest Cedex, France, 29609 Hopital Saint Vincent de Paul - GHICL Lille Lille cedex, France, 59020 Hôpital Saint-Louis (AP-HP), Centre Investigations Cliniques Paris Cedex 10, France, 75475 Germany Charite Research Organisation GmbH Berlin, Germany, 10117 Universitaetsklinikum Carl Gustav Carus TU Dresden Dresden, Germany, 01307 Universitaetsklinikum Freiburg Freiburg, Germany, 79106 Universitaetsklinikum Koeln Koeln, Germany, 50937 Italy Azienda ospedaliero universitaria Consorziale Policlinico di Bari Bari, BA, Italy, 70124 Azienda Ospedaliera Papa Giovanni XXIII Bergamo, BG, Italy, 24127 Azienda Ospedaliero-Universitaria Careggi, Florence Florence, FI, Italy, 50134 Fondazione IRCCS Policlinico San Matteo Pavia, PV, Italy, 27100 Istituto Tumori Giovanni Paolo II - IRCCS Ospedale Oncologico di Bari Bari, Italy, 70124 Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico Milano, Italy Università degli Studi di Napoli Federico II, Facoltà di Medicina e Chirurgia Napoli, Italy, 80131 Ospedale Civile dello Spirito Santo Pescara, Italy Azienda Ospedaliero Universitaria Pisana Pisa, Italy, 56126 Azienda Ospedaliera "Bianchi-Melacrino-Morelli" Reggio Calabria, Italy, 89125 Università Campus Bio-Medico di Roma Rome, Italy Ospedale San Bortolo di Vicenza Vicenza, Italy, 36100 Poland SP ZOZ Zespol Szpitali Miejskich w Chorzowie Chorzow, Poland, 41-500 Uniwersyteckie Centrum Kliniczne Gdansk, Poland, 80-952 United Kingdom Belfast City Hospital Belfast, United Kingdom, BT9 7BL Royal London Hospital London, United Kingdom, E1 1BB Royal Cornwall Hospital Truro, United Kingdom, TR1 3LJ Collapse <<
  NCT00442182	Autoinflammatory Syndromes ... more >> HIDS TRAPS Schnitzler's Syndrome Collapse <<	Phase 2	Unknown	-	Netherlands ... more >> Radboud University Medical Centre Nijmegen Recruiting Nijmegen, Netherlands, 6500 HB Sub-Investigator: Evelien J Bodar, MD Collapse <<

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• 参考文献

• [1] Li S, Fossati G, et al. Specific inhibition of histone deacetylase 8 reduces gene expression and production of proinflammatory cytokines in vitro and in vivo. J Biol Chem. 2015 Jan 23;290(4):2368-78.

  [2] Wang YG, Xu L, et al. Givinostat inhibition of hepatic stellate cell proliferation and protein acetylation. World J Gastroenterol. 2015 Jul 21;21(27):8326-39.