|(2R,3R,4S,5S,6R)-2-(((3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-二羟基-4,4,8,10,14-五甲基-17-(6-甲基庚-1,5-二烯-2-基)十六氢-1H-环戊[a]菲-6-基)氧基)-6-(羟甲基)四氢-2H-吡喃-3,4,5-三醇|CsnPharm

CAS No.: 364779-15-7

Ginsenoside Rk3/人参皂甙 Rk3 Catalog No. CSN18246

Synonyms: 人参皂甙 Rk3;人参皂苷Rk3

Ginsenoside Rk3 is reportedly present in the processed Radix notoginseng that is often used as a major ingredient of the compound preparation for ischemic heart diseases.

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技术信息

生物活性

描述Ginsenoside Rk3 (Rk3) is present in the roots of processed Panax notoginseng herbs and it exerts anti-platelet aggregation, pro-immunogenic and cardioprotective effects. Rk3 reduced cell viability, inhibited both cell proliferation and colony formation, and induced G1 phase cell cycle arrest by downregulating the expression of cyclin D1 and CDK4 and upregulating the expression of P21. Furthermore, Rk3 significantly inhibited the growth of H460 xenograft tumors without an obvious effect on the body weight of the treated mice^[3]. Ginsenoside Rk3 significantly inhibits TNF-α-induced NF-κB transcriptional activity, with an IC50 of 14.24 ± 1.30 μM in HepG2 cells. Consistent with the inhibition of NF-κB, Ginsenoside Rk3 inhibits the induction of IL8, CXCL1, iNOS, and ICAM1 mRNA significantly in a dose-dependent manner^[4]. The gene expressions of hepatic gluconeogenesis were also down-regulated by G-Rk3 in HFD/STZ (high-fat-diet/streptozocin) induced T2DM (anti-type 2 diabetes mellitus) mice. In addition, G-Rk3 suppressed HFD/STZ induced lipid accumulation by regulating related gene and protein expressions such as p-ACC, FAS and SREBP-1, which are the downstream targets of AMPK^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.6107 mL
- 8.0534 mL
- 16.1068 mL
- 5 mM
- 0.3221 mL
- 1.6107 mL
- 3.2214 mL
- 10 mM
- 0.1611 mL
- 0.8053 mL
- 1.6107 mL

技术信息

CAS号	364779-15-7	储存条件	粉末 Sealed in dry,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C36H60O8	运输	蓝冰
分子量	620.86	别名	人参皂甙 Rk3;人参皂苷Rk3

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