|(2S,3R,4S,5S,6R)-2-(((2R,3R,4S,5S,6R)-2-(((3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-二羟基-17-((S)-2-羟基-6-甲基庚-5-烯-2-基)-4,4,8,10,14-五甲基十六氢-1H-环戊[a]菲-6-基)氧基)-4,5-二羟基-6-(羟甲基)四氢-2H-吡喃-3-基)氧基)-6-(羟甲基)四氢-2H-吡喃-3,4,5-三醇|CsnPharm

CAS No.: 52286-58-5

Ginsenoside Rf/人参皂苷Rf Catalog No. CSN19480

Synonyms: Panaxoside Rf;人参皂苷 Rf

Ginsenoside Rf, extracted from the traditional Chinese herb ginseng, is a natural anticancer products known for its favorable safety and efficacy profiles.

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400-920-2911

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技术信息

生物活性

描述Ginsenoside Rf is a ginseng saponin found only in Panax ginseng that affects lipid metabolism. It also has neuroprotective and antiinflammatory properties. PPARγ protein levels and peroxisome proliferator response element promoter activities were promoted by ginsenoside Rf. Inhibition of COX-2 (cyclooxygenase-2) expression by ginsenoside Rf was blocked by the PPARγ-specific inhibitor, T0070907^[3]. Moreover, dose-dependent antinociception by systemic administration of Rf in mice using two separate assays of tonic pain: in the acetic acid abdominal constriction test, the ED50 was 56+/-9 mg/kg, a concentration similar to those reported for aspirin and acetaminophen in the same assay; in the tonic phase of the biphasic formalin test, the ED50 was 129+/-32 mg/kg^[4]. Daily Rf treatment (20 mg/kg, i.p.) throughout the experiment dramatically improved spatial learning and memory in Aβ42-induced mouse model of AD(Alzheimer's disease) ^[5]. Ginsenoside Rf alleviated neuropathic pain and its associated depression and restored the balance between proinflammatory and anti-inflammatory cytokines^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02204826	Male Infertility	Phase 4	Completed	-	Korea, Republic of ... more >> Department of Urology, Pusan National University Hospital Busan, Korea, Republic of, 602-739 Collapse <<
NCT02413099	Erectile Dysfunction	Phase 4	Completed	-	Korea, Republic of ... more >> Department of Urology, Pusan National University Hospital Busan, Korea, Republic of, 602-739 Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.2484 mL
- 6.2421 mL
- 12.4842 mL
- 5 mM
- 0.2497 mL
- 1.2484 mL
- 2.4968 mL
- 10 mM
- 0.1248 mL
- 0.6242 mL
- 1.2484 mL

技术信息

CAS号

52286-58-5

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C42H72O14

运输

蓝冰

分子量

801.01

别名

Panaxoside Rf;人参皂苷 Rf

溶解度

Ethanol

50.0 mg/mL (62.4 mM) warming

动物实验配方

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