|(2S,3R,4S,5S,6R)-2-(((2R,3R,4S,5S,6R)-4,5-二羟基-2-(((3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-羟基-4,4,8,10,14-五甲基-17-((S)-6-甲基-2-(((2S,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)庚-5-烯-2-基)十六氢-1H-环戊烷[a]菲-3-基)氧基)-6-(羟甲基)四氢-2H-吡喃-3-基)氧基)-6-(羟甲基)四氢-2H-吡喃-3,4,5-三醇|CsnPharm

CAS No.: 52705-93-8

Ginsenoside Rd/人参皂苷Rd Catalog No. CSN19489

Synonyms: Gypenoside VIII;Ginsenoside RD;人参皂苷 Rd

Ginsenoside Rd is a protopanaxadiol which has diverse in vitro and in vivo effects, including cardioprotective, neuroprotective, and anti-inflammatory actions.

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技术信息

生物活性

描述Ginsenoside Rd (GSRd), one of the main active ingredients in traditional Chinese herbal Panax ginseng, have therapeutic effects on ischemic stroke. in vitro, GSRd administration reduced mtDNA and nDNA damages and reduced cell apoptosis and the expression of cleaved caspase-3 in rats at 7 days after middle cerebral artery occlusion (MCAO)^[3]. Moreover, pretreatment with Rd at 1 or 10 μM in the medium partly reversed the Ca2+ induced mitochondrial swelling. in vivo, pretreatment with Rd (10 and 50 mg/kg) protected spinal cord mitochondria against Ca2+ induced mitochondrial membrane potential dissipation and cytochrome release^[4].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00815763	Ischemic Stroke	Phase 3	Completed	-	China, Shaanxi ... more >> the Department of Neurology , Xijing Hospital Xi'an, Shaanxi, China, 710032 Collapse <<
NCT00591084	Ischemic Stroke	Phase 2	Completed	-	China, Shaanxi ... more >> the Department of Neurology , Xijing Hospital Xi'an, Shaanxi, China, 710032 Collapse <<

参考文献

[1] Liu XY, Zhou XY, et al. Ginsenoside Rd promotes neurogenesis in rat brain after transient focal cerebral ischemia via activation of PI3K/Akt pathway. Acta Pharmacol Sin. 2015 Apr;36(4):421-8.
[2] Wang B, Zhu Q, et al. Ginsenoside Rd inhibits apoptosis following spinal cord ischemia/reperfusion injury. Neural Regen Res. 2014 Sep 15;9(18):1678-87.
[3] Yang LX, Zhang X, Zhao G. Ginsenoside Rd Attenuates DNA Damage by Increasing Expression of DNA Glycosylase Endonuclease VIII-like Proteins after Focal Cerebral Ischemia. Chin Med J (Engl). 2016;129(16):1955-1962.
[4] Zhou JS, Wang JF, He BR, et al. Ginsenoside Rd attenuates mitochondrial permeability transition and cytochrome C release in isolated spinal cord mitochondria: involvement of kinase-mediated pathways. Int J Mol Sci. 2014;15(6):9859-9877. Published 2014 Jun 3.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.0558 mL
- 5.2790 mL
- 10.5579 mL
- 5 mM
- 0.2112 mL
- 1.0558 mL
- 2.1116 mL
- 10 mM
- 0.1056 mL
- 0.5279 mL
- 1.0558 mL

技术信息

CAS号

52705-93-8

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C48H82O18

运输

蓝冰

分子量

947.15

别名

Gypenoside VIII;Ginsenoside RD;人参皂苷 Rd

溶解度

DMSO	90.0 mg/mL (95.0 mM)

动物实验配方

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