|(2S,3R,4S,5S,6R)-2-(((2R,3R,4S,5S,6R)-4,5-二羟基-2-(((3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-羟基-4,4,8,10,14-五甲基-17-((S)-6-甲基-2-(((2S,3R,4S,5S,6R)-3,4,5-三羟基-6-((((2S,3R,4S,5R)-3,4,5-三羟基四氢-2H-吡喃-2-基)氧基)甲基)四氢-2H-吡喃-2-基)氧基)庚-5-烯-2-基)十六氢-1H-环戊二烯并[a]菲-3-基)氧基)-6-(羟甲基)四氢-2H-吡喃-3-基)氧基)-6-(羟甲基)四氢-2H-吡喃-3,4,5-三醇|CsnPharm

CAS No.: 68406-26-8

Ginsenoside Rb3/人参皂苷 Rb3 Catalog No. CSN19502

Synonyms: Gypenoside IV;Ginsenoside IV;Ginsenoside C

Ginsenoside Rb3 is a natural triterpenoid saponin with various pharmacological effects.

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技术信息

生物活性

描述Ginsenoside Rb3 is extracted from steamed Panax notoginseng. Ginsenoside Rb3 exhibits inhibitory effect on TNFα-induced NF-κB transcriptional activity with an IC50 of 8.2 μM in 293T cell lines. This compound also inhibited the induction of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) messenger Ribonucleic acid (mRNA) in a dose-dependent manner after HepG2 cells had been treated with TNF-α (10 ng/mL)^[3]. Ginsenoside Rb(3) (0.1-10 micromol/L) significantly increased cell viability and inhibited LDH (lactate dehydrogenase) release in a dose-dependent manner on the ischemic model. In addition, ginsenoside Rb(3) also significantly inhibited ischemic injury-induced apoptosis, [Ca(2+)](i) elevation, and decrease of MMP(mitochondrial membrane potential)^[4]. G-Rb3 could protect heart functions in MI-induced HF model. G-Rb3 treatment up-regulated expressions of key enzymes involved in β-oxidation of fatty acids. The upstream transcriptional regulator, peroxisome proliferator-activated receptor α (PPARα), was also up-regulated by G-Rb3 treatment. G-Rb3 could protect mitochondrial membrane integrity and exert anti-apoptotic effects, in addition to regulating fatty acids oxidation^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 0.9266 mL
- 4.6328 mL
- 9.2655 mL
- 5 mM
- 0.1853 mL
- 0.9266 mL
- 1.8531 mL
- 10 mM
- 0.0927 mL
- 0.4633 mL
- 0.9266 mL

技术信息

CAS号

68406-26-8

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C53H90O22

运输

蓝冰

分子量

1079.27

别名

Gypenoside IV;Ginsenoside IV;Ginsenoside C;FT-0626701;CS-3831;人参皂苷 Rb3

溶解度

DMSO	100.0 mg/mL (92.7 mM)

动物实验配方

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