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CAS No.: 20261-38-5

Ginkgolic Acid (C13:0)/银杏酸(C13:0) Catalog No. CSN11098

Synonyms: Ginkgolic acid (13:0);Ginkgoneolic Acid;6-Tridecylsalicylic acid

Ginkgolic Acid C13:0 is a natural product with wide antimicrobial spectrum.

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技术信息

生物活性

描述Ginkgolic Acid (C13:0) is a natural anticariogenic agent in that it exhibits antimicrobial activity against S. mutans and suppresses the specific virulence factors associated with its cariogenicity. Ginkgoneolic acid inhibited not only the growth of S. mutans planktonic cells at minimum inhibitory concentration (MIC) of 4 μg/mL and minimum bactericidal concentration (MBC) of 8 μg/mL but also the acid production and adherence to saliva-coated hydroxyapatite of S. mutans at sub-MIC concentration. In addition, this agent was effective in inhibiting the biofilm formation of S. mutans (MBIC(50) = 4 μg/mL), and it reduced 1-day-developed biofilm of S. mutans by 50 % or more at low concentration (MBRC(50) = 32 μg/mL)^[2]. GA (Ginkgolic Acid) inhibits Herpes simplex virus type 1 (HSV-1) by inhibition of both fusion and viral protein synthesis. GA inhibits human cytomegalovirus (HCMV) genome replication and Zika virus (ZIKV) infection of normal human astrocytes (NHA). GA inhibits virion entry by blocking the initial fusion event^[3]. Moreover, ginkgolic acid inhibited the proliferation, migration and invasion of SW480 colon cancer cells by inducing AMPK activation and inhibiting the expression of invasion-associated proteins^[4]. Ginkgolic acid significantly reduced and reversed the ox-LDL(Oxidized low-density lipoprotein)-induced modulation, suggesting its anti-inflammatory effect via the NF-κB pathway^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.1205 mL
- 15.6023 mL
- 31.2045 mL
- 5 mM
- 0.6241 mL
- 3.1205 mL
- 6.2409 mL
- 10 mM
- 0.3120 mL
- 1.5602 mL
- 3.1205 mL

技术信息

CAS号

20261-38-5

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H32O3

运输

蓝冰

分子量

320.47

别名

Ginkgolic acid (13:0);Ginkgoneolic Acid;6-Tridecylsalicylic acid;Anacardic Acid A;Ginkgolic Acid C13:0;6-n-Tridecylsalicylic acid;6-n-TDSCA;AR-1E2490;银杏酸GA13：0

溶解度

DMSO	340.0 mg/mL (1061.0 mM)
Water	insoluble

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Ginkgolic Acid (C13:0)/银杏酸(C13:0) Catalog No. CSN11098

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