A2780 cells | - | Proliferation assay | - | Compound was evaluated for antiproliferative activity against human ovarian carcinoma cell line A2780, IC50=3.4 μM | 11514145 |
HCT116 cells | - | Proliferation assay | - | Antiproliferative activity against human HCT116 cells by luminescence assay, EC50=0.03 μM | 21605975 |
HEK293T cells | - | Function assay | - | Inhibition of TNF-alpha-induced NF-kappaB activation expressed in HEK293T cells by luciferase reporter gene assay | 18408713 |
HT-29 cell | - | Growth inhibition assay | - | Inhibitory concentration against human colorectal carcinoma HT-29 cell lines, IC50=24.5 nM | 15658879 |
human A431 cells | - | Cytotoxic assay | 72 h | Cytotoxicity against human A431 cells after 72 hrs by MTT assay, IC50=40 nM | 25277067 |
human A431 cells | - | Proliferation assay | 72 h | Antiproliferative activity against human A431 cells after 72 hrs, IC50=0.2 μM | 20655237 |
human A549 cells | - | Growth inhibition assay | - | Growth inhibition of human A549 cells, GI50=64 nM | 18243703 |
human A549 cells | - | Cytotoxic assay | 72 h | Cytotoxicity against human A549 cells after 72 hrs by MTT assay, IC50=97 nM | 25277067 |
human A549 cells | - | Cytotoxic assay | 2 days | Cytotoxicity against human A549 cells after 2 days by AlamarBlue assay, IC50=0.15 μM | 23947794 |
human BGC823 cells | - | Cytotoxic assay | 72 h | Cytotoxicity against human BGC823 cells after 72 hrs by MTT assay, IC50=40 nM | 25277067 |
human DLD1 cells | - | Growth inhibition assay | - | Growth inhibition of human DLD1 cells, GI50=37 nM | 18243703 |
human HCT116 cells | - | Growth inhibition assay | - | Growth inhibition of human HCT116 cells, GI50=21 nM | 18243703 |
human HeLa cells | - | Cytotoxic assay | 72 h | Cytotoxicity against human HeLa cells after 72 hrs by MTT assay, IC50=0.798 μM | 25277067 |
human HepG2 cells | - | Cytotoxic assay | 72 h | Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay, IC50=40 nM | 25277067 |
human HepG2 cells | - | Cytotoxic assay | - | Cytotoxicity against human HepG2 cells by MTT assay, IC50=0.3 μM | 23656556 |
human HL7702 cells | - | Cytotoxic assay | 72 h | Cytotoxicity against human HL7702 cells after 72 hrs by MTT assay, IC50=0.141 μM | 25277067 |
human Jurkat cells | - | Function assay | - | Inhibition of TNF-alpha-induced NF-kappaB activation expressed in FADD deficient human Jurkat cells by luciferase reporter gene assay | 18408713 |
human LNCAP cells | - | Cytotoxic assay | 72 h | Cytotoxicity against human LNCAP cells after 72 hrs by MTT assay, IC50=0.43 μM | 25105924 |
human LS174T cells | - | Cytotoxic assay | - | Cytotoxicity against human LS174T cells by MTS assay, IC50=0.45 μM | 17034135 |
human MCF7 cells | - | Cytotoxic assay | - | Cytotoxicity against human MCF7 cells by SRB assay, IC50=9.6 μM | 19560353 |
human MCF7 cells | - | Growth inhibition assay | - | Growth inhibition of human MCF7 cells after days by SRB assay, GI50=35.6 μM | 17869098 |
human MDA-MB-231 cells | - | Cytotoxic assay | 72 h | Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay, IC50=50 nM | 25277067 |
human SKBR3 cells | - | Cytotoxic assay | 72 h | Cytotoxicity against human SKBR3 cells after 72 hrs by celltiter-glo assay, IC50=41 nM | 19405528 |
human SKBR3 cells | - | Function assay | 24 h | Inhibition of Hsp90-mediated HER2 degradation in human SKBR3 cells after 24 hrs by Western blot | 18816111 |
human SK-BR-3 cells | - | Proliferation assay | - | Antiproliferative activity against human SK-BR-3 cells, IC50=15.8 nM | 19896848 |
human SW480 cells | - | Cytotoxic assay | 72 h | Cytotoxicity against human SW480 cells after 72 hrs by MTT assay, IC50=0.31 μM | 25277067 |
human U87MG cells | - | Proliferation assay | - | Antiproliferative activity against human U87MG cells, IC50=89 nM | 21715165 |
HUVEC cells | - | Cytotoxic assay | 72 h | Cytotoxicity against HUVEC cells after 72 hrs by MTT assay, IC50=19 nM | 25277067 |
K562 cell | - | Growth inhibition assay | - | Inhibitory concentration against human leukemia K562 cell lines, IC50=22.1 nM | 15658879 |
MCF-7 cell | - | Growth inhibition assay | - | Inhibitory concentration against human breast cancer MCF-7 cell lines, IC50=6.5 nM | 15658879 |
MCF7 cells | - | Proliferation assay | 72 h | Antiproliferative activity against human MCF7 cells expressing estrogen receptor after 72 hrs, IC50=9.8 nM | 23648180 |
MDA-kb2 cells | - | Function assay | 18 h | Inhibition of HSP90 in human MDA-kb2 cells assessed as reduction in glucocorticoid receptor-dependent luciferase expression after 18 hrs by firefly luciferase reporter gene assay, IC50=10 nM | 24984936 |
mouse P19 cells | - | Cytotoxic assay | 18 h | Cytotoxicity against mouse P19 cells after 18 hrs, IC50=0.1 μM | 17442565 |
NCI-H1975 cells | - | Proliferation assay | - | Antiproliferative activity against human NCI-H1975 cells, IC50=36 nM | 21715165 |
rat L6 cells | - | Cytotoxic assay | 72 h | Cytotoxicity against rat L6 cells after 72 hrs by Alamar Blue assay, IC50=5 μM | 24580531 |
Sf9 cells | - | Function assay | - | Displacement of GM-BODIPY from human full length HSP90 alpha expressed in baculovirus-infected Sf9 cells after 16 hrs by fluorescence polarization assay, IC50=74 nM | 24751441 |
SKBR3 cells | - | Proliferation assay | 72 h | Antiproliferative activity against estrogen receptor deficient human SKBR3 cells after 72 hrs, IC50=8.5 nM | 23648180 |
SW620 cell | - | Growth inhibition assay | - | Inhibitory concentration against human colorectal carcinoma SW620 cell lines, IC50=6.2 nM | 15658879 |