CAS No.: 1200129-48-1
GDC-0425 Catalog No. CSN20165
Synonyms: RG-7602
GDC-0425 is an oral, selective Chk1 inhibitor. GDC-0425 enhances gemcitabine (gem) efficacy in tumor xenograft models, and shows greater chemopotentiation in cancer cell lines lacking p53 activity.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT01359696 Solid Tumor Phase 1 Completed - United States, Michigan ... more >> Karmanos Cancer Institute.. Detroit, Michigan, United States, 48201 United States, Tennessee Sarah Cannon Cancer Center Nashville, Tennessee, United States, 37203 France Institut Gustave Roussy; Ser. de Med. Nucleaire; Cancerologie Endo Villejuif, France, 94805 Collapse << - 参考文献
- [1] Infante JR, Hollebecque A, et al. Phase I Study of GDC-0425, a Checkpoint Kinase 1 Inhibitor, in Combination with Gemcitabine in Patients with Refractory Solid Tumors. Clin Cancer Res. 2017 May 15;23(10):2423-2432.
- [2] Takahashi RH, Halladay JS, et al. Novel Mechanism of Decyanation of GDC-0425 by Cytochrome P450. Drug Metab Dispos. 2017 May;45(5):430-440.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1200129-48-1 | 储存条件 |
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| 分子式 | C18H19N5O | 运输 | 蓝冰 | |
| 分子量 | 321.38 | 别名 | RG-7602 |
