|灵芝酸A|CsnPharm

CAS No.: 81907-62-2

Ganoderic acid A/灵芝酸 A Catalog No. CSN11080

Synonyms: Ganoderic Acid A;灵芝酸 A

Ganoderic acid A, a natural product isolated and purified from the fruit body of Ganoderma lucidum, exhibits antitumor activity.

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技术信息

生物活性

描述Ganoderic acid A (GAA), a representative active triterpenoid from Ganoderma lucidum, has been reported to exhibit antinociceptive, antioxidative, cytotoxic, hepatoprotective and anticancer activities^[3]. GA-A (6.25-100 μM) significantly inhibited cyst growth in MDCK cyst model and embryonic kidney cyst model in vitro, and the inhibitory effect was reversible. In kidney-specific Pkd1 knockout (kPKD) mice displaying severe cystic kidney disease, administration of GA-A (50 mg· kg-1 ·d-1, sc) significantly attenuated renal cyst development^[4]. Pretreatment with GA A (10 μM) significantly attenuated SNP(sodium nitroprusside)-induced cytotoxicity and NO (nitric oxide) increase in SH-SY5Y cells, but not in PC12 cells. Furthermore, pretreatment with GA A caused significantly higher adrenaline content in SH-SY5Y cells than in PC12 cells^[5]. GAA attenuates acute lung injury in mouse model via the inhibition of Rho/ROCK/NF-κB pathway^[6].
细胞研究

Cell Data

Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources
Bel7402 cells	-	Cytotoxicity assay	-	Cytotoxicity against human Bel7402 cells, IC50=7.25 μM	23092389
HepG2 cells	-	Function assay	48 h	Anticancer activity against human HepG2 cells assessed as cell viability after 48 hrs by MTT assay, IC50=38.7 μM	24974349
P388 cells	-	Cytotoxicity assay	-	Cytotoxicity against mouse P388 cells, IC50=7.25 μM	23092389

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.9355 mL
- 9.6774 mL
- 19.3549 mL
- 5 mM
- 0.3871 mL
- 1.9355 mL
- 3.8710 mL
- 10 mM
- 0.1935 mL
- 0.9677 mL
- 1.9355 mL

技术信息

CAS号

81907-62-2

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C30H44O7

运输

蓝冰

分子量

516.67

别名

Ganoderic Acid A;灵芝酸 A

溶解度

DMSO	99.0 mg/mL (191.6 mM)
Water	Insoluble
Ethanol	100.0 mg/mL (193.5 mM) warming

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