生物活性

• 描述Fusidic acid as well as its sodium salt (Fusidic Acid Sodium), fusidin, is a relatively atoxic antibiotic used mainly in the treatment of staphylococcal infections. The drug has shown promise in preventing the disease in animal models of IDDM (Insulin-dependent diabetes mellitus) and in a preliminary trial in IDDM patients^[3]. Fusidic acid (Fusidic Acid Sodium), a steroidal antibiotic, possesses antimicrobial, antioxidant, and anti-inflammatory properties. Fusidic acid can protect C6 glial cells against cytotoxicity, through the regulation of AMPK (adenosine monophosphate-activated protein kinase) pathway and apoptotic events^[4]. Fusidic acid sodium salt (fusidic acid or FA) as an inhibitor of PRPK (p53-related protein kinase), and show that FA combined with 5-fluorouracil (5-FU) inhibited PRPK activity and colon cancer metastasis to the lung in mice^[5]. Fusidic acid was potent (MICs, 0.125 to 0.5 μg/ml; a single 500-mg dose of fusidic acid at 8 h averaged 8 to 12. 5 μg/ml with 91 to 97% protein binding) against all MRSA(methicillin-resistant Staphylococcus aureus) strains^[6].
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT03395132	Infected Atopic Dermatitis/Ecz... more >>ema Collapse <<	Phase 3	Recruiting	January 14, 2020	China ... more >> Children's Hospital, Capital Institute of Pediatrics Not yet recruiting Beijing, China, 100020 Beijing Children's Hospital, Capital Medical University Not yet recruiting Beijing, China, 100045 Peking Union Medical College Hospital Not yet recruiting Beijing, China, 100730 The First Affiliated Hospital of Chongqing Medical University Not yet recruiting Chongqing, China The First Hospital of Dalian Medical University Not yet recruiting Dalian, China, 116011 The Second Hospital of Dalian Medical University Not yet recruiting Dalian, China, 116023 Guangdong General Hospital Recruiting Guangzhou, China, 510080 Dermatology Hospital, China Academy of Medicine and Science Recruiting Nanjing, China, 210042 The Affiliated Hospital of Qingdao University Not yet recruiting Qingdao, China Shanghai Huashan Hospital Recruiting Shanghai, China, 200040 Children's Hospital of Shanghai Not yet recruiting Shanghai, China, 200062 General Hospital of Shenyang Military Not yet recruiting Shenyang, China, 110000 The People's Hospital of Liaoning Province Recruiting Shenyang, China, 110016 The First Affiliated Hospital of Soochow University Not yet recruiting Suzhou, China, 215006 Tongji Hospital of Tongji Medical College of Huazhong Univ. of Science & Technology Recruiting Wuhan, China, 430030 Tangdu Hospital Not yet recruiting Xi'an, China, 710038 Collapse <<
  NCT00133874	Skin Infections, Bacterial	Phase 3	Completed	-	-
  NCT03052348	Severe Atopic Dermatitis	Not Applicable	Not yet recruiting	August 30, 2018	South Africa ... more >> Nelson Mandela Academic Hospital Not yet recruiting Mthatha, Eastern Cape, South Africa, 5099 Contact: Avumile Mankahla, MBCHB    0836547566    Mankahla@gmail.com    Contact: Noluvuyo Qikani, MBCHB    0833821188    lmvuyo@gmail.com    King Edward Hospital Not yet recruiting Durban, KwaZulu Natal, South Africa, 4013 Contact: Ncoza Dlova, MBCHB    0312604530    Dlovan@ukzn.ac.za    Red Cross War Memorial Children's Hospital Cape Town, Western Cape, South Africa, 7700 Collapse <<

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• 参考文献

• [1] Milenkovc M, Arsenovic-Ranin N, et al. Fusidin ameliorates experimental autoimmune myocarditis in rats by inhibiting TNF-alpha production. Pharmazie. 2007 Jun;62(6):445-8.

  [2] Nicoletti F, Di Marco R, et al. Sodium fusidate ameliorates the course of diabetes induced in mice by multiple low doses of streptozotocin. J Autoimmun. 2000 Dec;15(4):395-405.

  [3] Nicoletti F, Meroni PL, Bendtzen K. Fusidic acid and insulin-dependent diabetes mellitus. Autoimmunity. 1996;24(3):187–197

  [4] Park E, Kim DK, Kim CS, Kim JS, Kim S, Chun HS. Protective effects of fusidic acid against sodium nitroprusside-induced apoptosis in C6 glial cells. Neuroreport. 2019;30(17):1222–1229

  [5] Zykova T, Zhu F, Wang L, et al. Targeting PRPK Function Blocks Colon Cancer Metastasis. Mol Cancer Ther. 2018;17(5):1101–1113

  [6] McGhee P, Clark C, Credito K, et al. In vitro activity of fusidic acid (CEM-102, sodium fusidate) against Staphylococcus aureus isolates from cystic fibrosis patients and its effect on the activities of tobramycin and amikacin against Pseudomonas aeruginosa and Burkholderia cepacia. Antimicrob Agents Chemother. 2011;55(5):2417–2419

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