CAS No.: 265121-04-8
Fosaprepitant Dimeglumine/福沙匹坦二甲葡胺 Catalog No. CSN12336
Synonyms: MK-0517;L785298;Fosaprepitant Dimeglumine Salt
Fosaprepitant Dimeglumine is a prodrug for aprepitant which is a selective and high-affinity antagonist of NK1 receptor.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
动物研究 剂量 Rat: 1 mg/kg, 8 mg/kg[3] (i.v.)
给药途径 i.v.
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT00090207 Nausea Vomiti... more >>ng Collapse << Phase 4 Completed - - NCT00726960 Opioid-Related Disorders ... more >> Heroin Dependence Substance-Related Disorders Collapse << Phase 1 Unknown June 2010 Sweden ... more >> Karolinska University Hospital, Huddinge Stockholm, Sweden, 14186 Collapse << NCT00717054 Nausea Vomiti... more >>ng Collapse << Not Applicable Completed - United States, Pennsylvania ... more >> Hahnemann University Hospital Philadelphia, Pennsylvania, United States, 19102 Collapse << - 更多
- 参考文献
- [1] Grunberg S, Chua D, et al. Single-dose fosaprepitant for the prevention of chemotherapy-induced nausea and vomiting associated with cisplatin therapy: randomized, double-blind study protocol--EASE. J Clin Oncol. 2011 Apr 10;29(11):1495-501.
- [2] Olver IN. Prevention of chemotherapy-induced nausea and vomiting: focus on fosaprepitant. Ther Clin Risk Manag. 2008 Apr;4(2):501-6.
- [3] Navari RM. Fosaprepitant (MK-0517): a neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea and vomiting. Expert Opin Investig Drugs. 2007 Dec;16(12):1977-85. doi: 10.1517/13543784.16.12.1977. PMID: 18042005.
- [4] Olver IN. Prevention of chemotherapy-induced nausea and vomiting: focus on fosaprepitant. Ther Clin Risk Manag. 2008 Apr;4(2):501-6. doi: 10.2147/tcrm.s2345. PMID: 18728837; PMCID: PMC2504061.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 265121-04-8 | 储存条件 |
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| 分子式 | C37H56F7N6O16P | 运输 | 蓝冰 | |||||
| 分子量 | 1004.83 | 别名 | MK-0517;L785298;Fosaprepitant Dimeglumine Salt;Fosaprepitant;Emend;Inemend;福沙吡坦二甲葡胺 | |||||
| 溶解度 |
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动物实验配方 |
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
|---|
| NCT00090207 | Nausea Vomiti... more >>ng Collapse << | Phase 4 | Completed | - | - |
| NCT00726960 | Opioid-Related Disorders ... more >> Heroin Dependence Substance-Related Disorders Collapse << | Phase 1 | Unknown | June 2010 | Sweden ... more >> Karolinska University Hospital, Huddinge Stockholm, Sweden, 14186 Collapse << |
| NCT00717054 | Nausea Vomiti... more >>ng Collapse << | Not Applicable | Completed | - | United States, Pennsylvania ... more >> Hahnemann University Hospital Philadelphia, Pennsylvania, United States, 19102 Collapse << |
| NCT00717054 | - | - | Completed | - | - |
| NCT00699894 | Postoperative Nausea and Vomit... more >>ing Collapse << | Not Applicable | Withdrawn(Logistical difficult... more >>ies running the study) Collapse << | - | United States, New York ... more >> Long Island Jewish Medical Center/Schneider's Children Hospital New Hyde Park, New York, United States, 11040 Collapse << |
| NCT00499668 | Myeloproliferative Disorders ... more >> Leukemia Lymphoma Lymphoproliferative Disorder Multiple Myeloma and Plasma Cell Neoplasm Myelodysplastic Syndromes Nausea and Vomiting Solid Tumor Collapse << | Not Applicable | Withdrawn(slow accrual) | - | - |
| NCT00954941 | - | - | Completed | - | - |
| NCT00659945 | - | - | Completed | - | - |
| NCT00970905 | Nausea Vomiti... more >>ng Collapse << | Phase 2 | Completed | - | United States, Arizona ... more >> Mayo Clinic Arizona Scottsdale, Arizona, United States, 85259-5499 United States, North Carolina Wake Forest Baptist Health Winston-Salem, North Carolina, United States, 27157 United States, Vermont Fletcher Allen Health Care Burlington, Vermont, United States, 05401 Collapse << |
| NCT00090155 | Postoperative Nausea and Vomit... more >>ing Collapse << | Phase 3 | Completed | - | - |
| NCT02097823 | Chemotherapy Induced Nausea an... more >>d Vomiting Collapse << | Phase 2 | Completed | - | United States, Indiana ... more >> Riley Hospital for Children at Indiana University Health Indianapolis, Indiana, United States, 46202 Collapse << |
| NCT00954941 | Hematologic Diseases ... more >> Acute Myelogenous Leukemia Myelodysplastic Syndrome Chronic Myelogenous Leukemia Collapse << | Phase 2 | Completed | - | United States, Texas ... more >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Collapse << |
| NCT02097823 | - | - | Completed | - | - |
| NCT01020903 | Postoperative Nausea | Not Applicable | Completed | - | United States, New York ... more >> Staten Island University Hospital Staten Island, New York, United States, 10305 Collapse << |
| NCT00738621 | Postoperative Nausea and Vomit... more >>ing Collapse << | Phase 4 | Completed | - | United States, Texas ... more >> Scott and White Healthcare Temple, Texas, United States, 76508 Collapse << |
| NCT00659945 | Postoperative Nausea and Vomit... more >>ing Collapse << | Phase 4 | Completed | - | United States, Pennsylvania ... more >> UPMC Magee Women's Hospital Pittsburgh, Pennsylvania, United States, 15213 Collapse << |
| NCT00090246 | Postoperative Nausea and Vomit... more >>ing Collapse << | Phase 3 | Completed | - | - |
| NCT01534637 | - | - | Completed | - | - |
| NCT01176591 | Cocaine Alcoh... more >>ol Dependence Collapse << | Phase 2 | Terminated | - | United States, Pennsylvania ... more >> University of Pennsylvania, Treatment Research Center Philadelphia, Pennsylvania, United States, 19104 Collapse << |
| NCT01534637 | Extrahepatic Bile Duct Cancer ... more >> Nausea Vomiting Stage II Pancreatic Cancer Stage III Pancreatic Cancer Stage IV Pancreatic Cancer Collapse << | Phase 2 | Completed | - | United States, North Carolina ... more >> Wake Forest University Health Sciences Winston-Salem, North Carolina, United States, 27157 Collapse << |
| NCT01088022 | Nausea Vomiti... more >>ng Collapse << | Phase 3 | Unknown | April 2013 | Italy ... more >> Azienda Ospedaliera di Perugia - Hematology dept. Not yet recruiting Perugia, Italy, 06100 Principal Investigator: Leonardo Flenghi, M.D. Collapse << |
| NCT00835965 | Nausea Vomiti... more >>ng Collapse << | Not Applicable | Unknown | - | United States, Pennsylvania ... more >> Lankenau Hospital Wynnewood, Pennsylvania, United States, 19096 Collapse << |
| NCT01020903 | - | - | Completed | - | - |
| NCT02445872 | Chemotherapy-Induced Nausea an... more >>d Vomiting Lung Cancer Collapse << | Phase 2 | Unknown | May 2016 | China, Zhejiang ... more >> The first affiliated hospital, Zhejiang University Hangzhou, Zhejiang, China, 310003 Collapse << |
| NCT01683552 | ITCH | Phase 2 | Completed | - | Italy ... more >> Campus Bio-Medico of Rome University Roma, Italy, 00128 Collapse << |
| NCT02210195 | - | - | Completed | - | - |
| NCT02364804 | - | - | Unknown | September 2015 | Japan ... more >> Shiga University of Medical Science Hospital Otsu, Shiga, Japan, 520-2192 Collapse << |
| NCT02357693 | Postoperative Nausea and Vomit... more >>ing Collapse << | Phase 4 | Completed | - | Brazil ... more >> Angela Maria Sousa Sao Paulo, São Paulo, Brazil, 01403010 Collapse << |
| NCT02210195 | Cannabis Dependence ... more >> Alcohol Dependence Cannabis Use Disorder Alcohol Use Disorder Collapse << | Phase 2 | Completed | - | United States, California ... more >> The Scripps Research Institute La Jolla, California, United States, 92037 Collapse << |
| NCT01625455 | Sezary Syndrome ... more >> Pruritus Collapse << | Phase 4 | Terminated(Difficulty recruiti... more >>ng.) Collapse << | - | United States, Tennessee ... more >> Vanderbilt University Medical Center Nashville, Tennessee, United States, 37235 Collapse << |
| NCT01625455 | - | - | Terminated(Difficulty recruiti... more >>ng.) Collapse << | - | - |
| NCT00896038 | Alcoholism Al... more >>cohol Dependence Posttraumatic Stress Disorder Collapse << | Phase 2 | Completed | - | United States, Maryland ... more >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Collapse << |
| NCT01334086 | Acute Myeloid Leukemia | Phase 2 | Completed | - | Canada, Ontario ... more >> Princess Margaret Hospital Toronto, Ontario, Canada, M5G 2M9 Collapse << |
| NCT01527994 | Opioid Dependence | Phase 1 | Completed | - | United States, New York ... more >> Bellevue Hospital Center & the NYU School of Medicine New York, New York, United States, 10016 Collapse << |
| NCT00888329 | Postoperative Nausea and Vomit... more >>ing Collapse << | Phase 4 | Terminated(Slow accrual.) | - | United States, Arizona ... more >> Mayo Clinic Phoenix, Arizona, United States, 85054 Collapse << |
| NCT00896038 | - | - | Completed | - | - |
| NCT01149369 | Gastroparesis | Phase 3 | Completed | - | United States, California ... more >> California Pacific Medical Center San Francisco, California, United States, 94115 Stanford University Stanford, California, United States, 94305-5187 United States, Kentucky University of Louisville Louisville, Kentucky, United States, 40202 United States, Maryland Johns Hopkins Bayview Medical Center Baltimore, Maryland, United States, 21224 United States, Michigan University of Michigan Medical Center Ann Arbor, Michigan, United States, 48109 United States, North Carolina Wake Forest University Health Sciences Winston-Salem, North Carolina, United States, 27157 United States, Pennsylvania Temple University Hospital Philadelphia, Pennsylvania, United States, 19140 United States, Texas Texas Tech University Health Sciences Center El Paso, Texas, United States, 79905 Collapse << |
| NCT01897337 | Postoperative Nausea and Vomit... more >>ing Collapse << | Phase 4 | Completed | - | Korea, Republic of ... more >> Gangnam severance hospital Seoul, Korea, Republic of Collapse << |
| NCT02205164 | Chemotherapy Induced Nausea an... more >>d Vomiting Collapse << | Phase 2 | Unknown | October 2014 | Italy ... more >> Università-Azienda Policlinico di Bari Active, not recruiting Bari, BA, Italy, 70124 Ospedale Perrino Recruiting Brindisi, BR, Italy, 72010 Contact: Angela Melpignano, MD brinemat@tin.it Principal Investigator: Angela Melpignano, MD Ospedale Pugliese-Ciacco Active, not recruiting Catanzaro, CZ, Italy, 88100 IRCCS Casa Sollievo della Sofferenza Recruiting San Giovanni Rotondo, FG, Italy, 71013 Contact: Nicola Cascavilla, MD nicola.cascavilla@tin.it Principal Investigator: Nicola Cascavilla, MD Ospedale Vito Fazzi Recruiting Lecce, LE, Italy, 73100 Contact: Nicola Di Renzo, MD direnzo.ematolecce@libero.it Principal Investigator: Nicola Di Renzo, MD Ospedale "Cardinale Panico" Recruiting Tricase, LE, Italy, 73100 Contact: Vincenzo Pavore, MD salentoematologia@piafondazionepanico.it Principal Investigator: Vincenzo Pavone, MD A.O. Riuniti Papardo - Piemonte Recruiting Messina, ME, Italy, 98121 Contact: Donato Mannina, MD donadani@tiscali.it Principal Investigator: Donato Mannina, MD Casa di Cura "La Maddalena" Recruiting Palermo, PA, Italy, 90127 Contact: Maurizio Musso, MD mamusso@libero.it Principal Investigator: Maurizio Musso, MD Ospedale Ascoli Civico Palermo Recruiting Palermo, PA, Italy, 90127 Contact: Anxur Merenda, MD anxurmerenda@libero.it Principal Investigator: Anxur Merenda, MD Ospedale Moscati Recruiting Taranto, TA, Italy, 74100 Contact: Patrizio Mazza, MD ematologia.taranto@libero.it Principal Investigator: Patrizio Mazza, MD ARON " Cardarelli" Recruiting Napoli, Italy, 80121 Contact: Felicetto Ferrara, MD felicettoferrara@katamail.com Principal Investigator: Felicetto Ferrara, MD Collapse << |
| NCT02161991 | Carcinoma, Non-small Cell Lung | Phase 3 | Unknown | December 2017 | China, Hunan ... more >> Hunan province tumor hospital Recruiting Changsha, Hunan, China Contact: Chunhua Zhou, MD +86 731 89762321 zhouchunhua@hnszlyy.com Collapse << |
| NCT02226601 | Cognitive Dysfunction | Not Applicable | Unknown | - | United States, Arizona ... more >> University of Arizona Medical Center Recruiting Tucson, Arizona, United States, 85724 Principal Investigator: Kai Schoenhage, MD Collapse << |
| NCT02347878 | Leukemia Lymp... more >>homa Collapse << | Phase 4 | Unknown | December 2015 | China, Guangdong ... more >> Sun Yat-sen University Cancer Center Not yet recruiting Guangzhou, Guangdong, China, 510060 Contact: Liang Wang, Doctor +86-20-87342462 wangliang@sysucc.org.cn Collapse << |
| NCT02989467 | Healthy | Phase 1 | Completed | - | United States, Minnesota ... more >> Mayo Clinic in Rochester Rochester, Minnesota, United States, 55905 Collapse << |
| NCT00659737 | Nausea Vomiti... more >>ng Collapse << | Not Applicable | Completed | - | United States, Pennsylvania ... more >> Hahnemann University Hospital Philadelphia, Pennsylvania, United States, 19102 Collapse << |
| NCT00293384 | Breast Cancer ... more >> Chronic Myeloproliferative Disorders Gestational Trophoblastic Tumor Leukemia Lymphoma Multiple Myeloma and Plasma Cell Neoplasm Myelodysplastic Syndromes Myelodysplastic/Myeloproliferative Neoplasms Nausea and Vomiting Neuroblastoma Ovarian Cancer Testicular Germ Cell Tumor Collapse << | Not Applicable | Completed | - | United States, Michigan ... more >> Barbara Ann Karmanos Cancer Institute Detroit, Michigan, United States, 48201-1379 Collapse << |
| NCT00659737 | - | - | Completed | - | - |
| NCT00337727 | Chemotherapy-Induced Nausea an... more >>d Vomiting Collapse << | Phase 3 | Completed | - | - |
| NCT00337727 | - | - | Completed | - | - |
| NCT01611948 | Cannabis Dependence | Phase 2 | Completed | - | United States, California ... more >> The Scripps Research Institute La Jolla, California, United States, 92037 Collapse << |
| NCT02732015 | Sarcoma | Phase 2 | Recruiting | October 2019 | United States, Texas ... more >> University of Texas MD Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Collapse << |
| NCT02106494 | Chemotherapy-induced Nausea an... more >>d Vomiting Collapse << | Phase 3 | Completed | - | United States, Arizona ... more >> Arizona Oncology Associates, PC-HAL Pheonix, Arizona, United States, 85016 United States, California The Oncology Institute of Hope and Innovation Downey, California, United States, 90241 Compassionate Cancer Medical Center Riverside, California, United States, 92501 United States, Indiana Northern Indiana Research Mishawaka, Indiana, United States, 46545 Northern Indiana Research South Bend, Indiana, United States, 46804 United States, New York North Shore Oncology East Setauket, New York, United States, 11733 United States, Ohio Gabrail Cancer Center Research Canton, Ohio, United States, 44718 Collapse << |
| NCT00293384 | - | - | Completed | - | - |
| NCT01611948 | - | - | Completed | - | - |
| NCT00781768 | Nausea Vomiti... more >>ng Collapse << | Phase 4 | Completed | - | - |
| NCT02106494 | - | - | Completed | - | - |
| NCT00781768 | - | - | Completed | - | - |
| NCT01732458 | Post-operative Nausea ... more >> Post-operative Vomiting Collapse << | Phase 2 | Completed | - | - |
| NCT01362530 | Chemotherapy Induced Nausea an... more >>d Vomiting Collapse << | Phase 3 | Completed | - | - |
| NCT00571168 | Multiple Myeloma | Phase 3 | Unknown | December 2010 | Germany ... more >> University Hospital of Heidelberg, Department V Recruiting Heidelberg, Germany, 69120 Principal Investigator: Gerlinde Egerer, MD Collapse << |
| NCT00711555 | Nausea Vomiti... more >>ng Collapse << | Phase 2 | Completed | - | United States, Illinois ... more >> University of Illinois Medical Center Chicago, Illinois, United States, 60612 Collapse << |
| NCT01249001 | Nausea Vomiti... more >>ng Chemotherapy Collapse << | Phase 2 | Terminated(lack of eligible pa... more >>rticipants to enrol) Collapse << | - | Canada, Ontario ... more >> The Hospital for Sick Children Toronto, Ontario, Canada, M5G 1X8 Collapse << |
| NCT00080444 | Vomiting | Phase 3 | Completed | - | - |
| NCT00888329 | - | - | Terminated(Slow accrual.) | - | - |
| NCT00819039 | - | - | Completed | - | - |
| NCT01362530 | - | - | Completed | - | - |
| NCT02635984 | Complications of Bone Marrow T... more >>ransplant Hematologic Neoplasms Collapse << | Phase 3 | Completed | - | United States, Georgia ... more >> Augusta University Medical Center Augusta, Georgia, United States, 30912 Collapse << |
| NCT00711555 | - | - | Completed | - | - |
| NCT01636947 | Nausea Vomiti... more >>ng Collapse << | Phase 4 | Completed | - | - |
| NCT00819039 | Postoperative Nausea and Vomit... more >>ing Collapse << | Phase 1 | Completed | - | United States, Kentucky ... more >> Call for Information (Investigational Site 0003) Louisville, Kentucky, United States, 40202 United States, Tennessee Call for Information (Investigational Site 0022) Nashville, Tennessee, United States, 37232 Brazil MSD Sao Paulo, SP, Brazil, 04717-004 Mexico MSD Mexico City, Mexico, 1090 Spain Merck Sharp and Dohme de Espana S.A. Madrid, Spain, 28027 Turkey Merck Sharp & Dohme Ilaclari Ltd. Sti Istanbul, Turkey Collapse << |
| NCT01757210 | - | - | Completed | - | United States, West Virginia ... more >> WVU Healthcare Morgantown, West Virginia, United States, 26506 Collapse << |
| NCT00092196 | Nausea Vomiti... more >>ng Breast Neoplasms Collapse << | Phase 3 | Completed | - | - |
| NCT02635984 | - | - | Completed | - | - |
| NCT00428519 | HIV Infections | Phase 1 | Completed | - | United States, Pennsylvania ... more >> Clinical Trials Unit. University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 Collapse << |
| NCT01732458 | - | - | Completed | - | - |
| NCT03035838 | Traumatic Brain Injury | Early Phase 1 | Not yet recruiting | April 2021 | - |
| NCT01636947 | - | - | Completed | - | - |
| NCT03237611 | Chemotherapy-induced Nausea an... more >>d Vomiting Collapse << | Phase 2 | Not yet recruiting | September 18, 2018 | - |
| NCT00952341 | Chemotherapy-induced Nausea an... more >>d Vomiting (CINV) Collapse << | Phase 3 | Completed | - | - |
| NCT01450826 | Nausea Vomiti... more >>ng Glioma Collapse << | Phase 2 | Completed | - | United States, North Carolina ... more >> The Preston Robert Tisch Brain Tumor Center at Duke Durham, North Carolina, United States, 27710 Collapse << |
| NCT00092183 | Nausea Vomiti... more >>ng Breast Neoplasms Collapse << | Phase 4 | Completed | - | - |
| NCT00035295 | Major Depressive Disorder | Phase 3 | Completed | - | - |
| NCT00034944 | Major Depressive Disorder | Phase 3 | Completed | - | - |
| NCT02154360 | HIV Infection | Phase 1 | Completed | - | United States, Pennsylvania ... more >> Hospital of the University of Pennsylvania Clinical Research Site Philadelphia, Pennsylvania, United States, 19104 Collapse << |
| NCT00231777 | Post-Operative Nausea and Vomi... more >>ting Collapse << | Phase 3 | Completed | - | - |
| NCT00952341 | - | - | Completed | - | - |
| NCT00619359 | Chemotherapy-Induced Nausea an... more >>d Vomiting (CINV) Collapse << | Phase 3 | Completed | - | - |
| NCT00231777 | - | - | Completed | - | - |
| NCT00035282 | Major Depressive Disorder | Phase 3 | Completed | - | - |
| NCT00619359 | - | - | Completed | - | - |
| NCT03606369 | Breast Neoplasm ... more >> Antineoplastic Agents Antiemetics Quality of Life Collapse << | Phase 2 Phase 3 | Recruiting | December 31, 2020 | Mexico ... more >> Instituto Nacional de Cancerología Recruiting Mexico City, Mexico, 14080 Contact: Julieta Santamaría Galicia, BD 56280400 ext 12065 ztinala@yahoo.es Collapse << |
| NCT00042029 | Major Depressive Disorder | Phase 3 | Completed | - | - |
| NCT00034983 | Major Depressive Disorder | Phase 3 | Completed | - | - |
| NCT00048607 | Major Depressive Disorder | Phase 3 | Completed | - | - |
| NCT00035048 | Major Depressive Disorder | Phase 3 | Completed | - | - |
| NCT00048594 | Major Depressive Disorder | Phase 3 | Completed | - | - |
| NCT01450826 | - | - | Completed | - | - |
| NCT03586817 | Nausea and Vomiting, Postopera... more >>tive Collapse << | Phase 4 | Not yet recruiting | August 1, 2019 | Brazil ... more >> Hospital Federal de Bonsucesso Rio de Janeiro, Brazil, 21041-030 Collapse << |
| NCT01490060 | - | - | Completed | - | - |
| NCT00035009 | Major Depressive Disorder | Phase 3 | Completed | - | - |
| NCT00895245 | Nausea and Vomiting ... more >> Stage III Squamous Cell Carcinoma of the Hypopharynx Stage III Squamous Cell Carcinoma of the Larynx Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity Stage III Squamous Cell Carcinoma of the Nasopharynx Stage III Squamous Cell Carcinoma of the Oropharynx Stage IV Squamous Cell Carcinoma of the Hypopharynx Stage IV Squamous Cell Carcinoma of the Larynx Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity Stage IV Squamous Cell Carcinoma of the Nasopharynx Stage IV Squamous Cell Carcinoma of the Oropharynx Collapse << | Phase 2 | Terminated(Study stopped due t... more >>o lack of efficacy in first 6 patients) Collapse << | - | United States, Washington ... more >> Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium Seattle, Washington, United States, 98109 Collapse << |
| NCT00895245 | - | - | Terminated(Study stopped due t... more >>o lack of efficacy in first 6 patients) Collapse << | - | - |
| NCT01111851 | Chemotherapy-Induced Nausea an... more >>d Vomiting (CINV) Collapse << | Phase 1 | Completed | - | - |
| NCT01111851 | - | - | Completed | - | - |
| NCT01344304 | Colorectal Cancer | Not Applicable | Unknown | March 2014 | Japan ... more >> Kansai Rosai Hospital Recruiting Amagasaki, Hyogo, Japan, 6600064 Contact: Rei Suzuki Kinki Central Hospital Recruiting Itami, Hyogo, Japan, 6640872 Contact: Takamichi Komori Kawasaki Hospital Recruiting Kobe, Hyogo, Japan, 6520042 Contact: Toshihiro Kimura Nara Hospital Kinki University Faculty of Medicine Recruiting Ikoma, Nara, Japan, 6300293 Contact: Kotaro Kitani Higashiosaka City General Hospital Recruiting Higashi-Osaka, Osaka, Japan, 5788588 Contact: Masaki Okuyama Saito Yukoukai Hospital Recruiting Ibaraki, Osaka, Japan, 5670085 Contact: Taro Hayashi 0726416898 Rinku General Medical Center Recruiting Izumisano, Osaka, Japan, 5988577 Contact: Hitoshi Mizuno Kaizuka City Hospital Recruiting Kaizuka, Osaka, Japan, 5970015 Contact: Hiroshi Nakano Hannan Chuo Hospital Recruiting Matsubara, Osaka, Japan, 5800023 Contact: Isao Arai Minoh City Hospital Recruiting Minoo, Osaka, Japan, 5620014 Contact: Yasuhiro Miyake Sakai City Hospital Recruiting Sakai, Osaka, Japan, 5900064 Contact: Hiroyoshi Takemoto Osaka Rosai Hospital Recruiting Sakai, Osaka, Japan, 5918025 Contact: Hajime Hirose Suita Municipal Hospital Recruiting Suita, Osaka, Japan, 5640082 Contact: Takashi Yoshino Saiseikai Senri Hospital Recruiting Suita, Osaka, Japan, 5650862 Contact: Hirofumi Ota Graduate School of Medicine / Faculty of Medicine, Osaka University Recruiting Suita, Osaka, Japan Contact: Junichi Nishimura jnishimura@gesurg.med.osaka-u.ac.jp Toyonaka Municipal Hospital Recruiting Toyonaka, Osaka, Japan, 5608565 Contact: Taishi Hata Yao Municipal Hospital Recruiting Yao, Osaka, Japan, 5810069 Contact: Yoshihito Ide Kenporen Osaka Central Hospital Recruiting Osaka, Japan, 5300001 Contact: Masato Yoshikawa 0647955505 Iseikai Hospital Recruiting Osaka, Japan, 5330022 Contact: Takahiko Tanigawa Osaka Medical Center for Cancer and Cardiovascular Diseases Recruiting Osaka, Japan, 5378511 Contact: Tatsushi Shingai National Hospital Organization Osaka National Hospital Recruiting Osaka, Japan, 5400006 Contact: Masayoshi Yasui NTT West Osaka Hospital Recruiting Osaka, Japan, 5430042 Contact: Katsuki Danno Nissay Hospital Recruiting Osaka, Japan, 5500012 Contact: Shohei Maeda Tane General Hospital Recruiting Osaka, Japan, 5500024 Contact: Atsuhiro Ogawa Osaka Seninhoken Hospital Recruiting Osaka, Japan, 5520021 Contact: Yasunori Watanabe Osaka Koseinenkin Hospital Recruiting Osaka, Japan, 5530003 Contact: Makoto Fujii 06-6441-5451 Osaka General Medical Center Recruiting Osaka, Japan, 5588558 Contact: Hiroshi Tamagawa Collapse << |
| NCT01101529 | Nausea Vomiti... more >>ng Collapse << | Phase 2 | Completed | - | Sweden ... more >> Uppsala University Hospital Uppsala, Sweden, 75185 Collapse << |
| NCT00818259 | Chemotherapy-Induced Nausea an... more >>d Vomiting Collapse << | Phase 1 | Terminated(Study terminated ea... more >>rly prior to completing targeted enrollment of participants <6 months of age due to recruitment challenges.) Collapse << | - | - |
| NCT01661335 | Nausea Vomiti... more >>ng Childhood Cancer Collapse << | Phase 3 | Recruiting | December 2018 | United States, Oklahoma ... more >> Jimmy Everest Center for Cancer and Blood Disorders in Children Recruiting Oklahoma City, Oklahoma, United States, 73104 Principal Investigator: Rene McNall-Knapp, MD Collapse << |
| NCT01300988 | HIV Infection | Phase 1 | Completed | - | United States, Pennsylvania ... more >> Clinical Trials Unit. University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104--607 Collapse << |
| NCT01697579 | Chemotherapy-induced Nausea an... more >>d Vomiting Collapse << | Phase 2 | Completed | - | - |
| NCT01017809 | Ovarian Cancer | Not Applicable | Withdrawn(NYU 03-67 reached ac... more >>crual prior to this study opening.) Collapse << | December 2013 | United States, New York ... more >> NYU Clinical Cancer Center New York, New York, United States, 10016 Collapse << |
| NCT01697579 | - | - | Completed | - | - |
| NCT01432015 | Ovarian Cancer ... more >> Uterine Cancer Collapse << | Phase 4 | Completed | - | United States, California ... more >> Gynecologic Oncology Associates Newport Beach, California, United States, 92663 Collapse << |
| NCT01432015 | - | - | Completed | - | - |
| NCT00212602 | Malignant Tumor | Phase 2 | Completed | - | Japan ... more >> Chubu Region Facility Chubu, Japan Chugoku Region Facility Chugoku, Japan Hokkaido Region Facility Hokkaido, Japan Hokuriku Region Facility Hokuriku, Japan Kanto Region Facility Kanto, Japan Kinki Region Facility Kinki, Japan Kyushu Region Facility Kyushu, Japan Shikoku Region Facility Shikoku, Japan Tohoku Region Facility Tohoku, Japan Collapse << |
| NCT01186029 | Postoperative Nausea and Vomit... more >>ing Collapse << | Not Applicable | Withdrawn(It didn't get IRB ap... more >>proval.) Collapse << | October 2011 | United States, Nebraska ... more >> University of Nebraska Medical Center Omaha, Nebraska, United States, 68198 Collapse << |
| NCT01736917 | Chemotherapy-Induced Nausea an... more >>d Vomiting Collapse << | Phase 2 | Completed | - | United States, Indiana ... more >> Indiana University Melvin and Bren Simon Cancer Center Indianapolis, Indiana, United States, 46202 United States, Missouri Siteman Cancer Center St. Louis, Missouri, United States, 63110 United States, Nebraska Nebraska Cancer Specialists Omaha, Nebraska, United States, 68114 United States, South Carolina MUSC Hollings Cancer Center Charleston, South Carolina, United States, 29425 Collapse << |
| NCT00818259 | - | - | Terminated(Study terminated ea... more >>rly prior to completing targeted enrollment of participants <6 months of age due to recruitment challenges.) Collapse << | - | - |
| NCT00990821 | Chemotherapy-Induced Nausea an... more >>d Vomiting Postoperative Nausea and Vomiting Collapse << | Phase 1 | Completed | - | - |
| NCT01649258 | Breast Cancer ... more >> Nausea Vomiting Collapse << | Phase 1 | Terminated(Lack of Efficacy) | - | United States, California ... more >> USC Norris Comprehensive Cancer Center Los Angeles, California, United States, 90033 Collapse << |
| NCT00945321 | Chemotherapy-Induced Nausea an... more >>d Vomiting Collapse << | Phase 1 | Completed | - | - |
| NCT01490060 | Sarcoma Chemo... more >>therapy-induced Nausea and Vomiting Effects of Chemotherapy Adverse Effects of Medical Drugs Collapse << | Not Applicable | Completed | - | United States, Texas ... more >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030-3722 Collapse << |
| NCT00990821 | - | - | Completed | - | - |
| NCT00945321 | - | - | Completed | - | - |
| NCT01074697 | Nausea Vomiti... more >>ng Genital Neoplasms, Female Collapse << | Phase 3 | Completed | - | Australia ... more >> RAH Cancer Centre, Royal Adelaide Hospital Adelaide SA, Australia, 5000 Denmark Department of Oncology Aarhus, Denmark, 8000 Rigshospitalet, Finsen Centret Copenhagen, Denmark, 2100 Herlev Hospital Herlev, Denmark, 2730 Department of Oncology, Odense University Hospital Odense, Denmark, 5000 Germany Vivantes Klinikum Neukolln Berlin, Germany Universitatsklinikum Schleswig Holstein Kiel, Germany, 24105 Norway The Norwegian Radium Hospital Oslo, Norway, 0310 Collapse << |
| NCT01594749 | Chemotherapy-Induced Nausea an... more >>d Vomiting (CINV) Collapse << | Phase 3 | Completed | - | - |
| NCT02519842 | Chemotherapy-induced Nausea an... more >>d Vomiting Collapse << | Phase 3 | Terminated(Further data are no... more >> longer required to support an application for use in pediatric patients. The decision to terminate was not based on any new safety findings) Collapse << | - | - |
| NCT03578081 | Malignant Neoplasm | Phase 3 | Recruiting | March 2020 | - |
| NCT01405924 | Nausea Vomiti... more >>ng Collapse << | Phase 2 | Terminated(Low enrollment) | - | - |
| NCT02519842 | - | - | Terminated(Further data are no... more >> longer required to support an application for use in pediatric patients. The decision to terminate was not based on any new safety findings) Collapse << | - | - |
| NCT01405924 | - | - | Terminated(Low enrollment) | - | - |
| NCT01031953 | Breakthrough Nausea and Vomiti... more >>ng Unspecified Adult Solid Tumor, Protocol Specific Collapse << | Phase 1 Phase 2 | Terminated(Drug contract timel... more >>ines and inadequate enrollment) Collapse << | - | United States, Oregon ... more >> Knight Cancer Institute at Oregon Health and Science University Portland, Oregon, United States, 97239-3098 Collapse << |
| NCT03197064 | Postoperative Nausea | Phase 4 | Not yet recruiting | January 31, 2019 | United States, California ... more >> Stanford University Medical Center Not yet recruiting Palo Alto, California, United States, 94305 Contact: Mark A Burbridge, MD 650-353-8484 markburb@stanford.edu Contact: Richard A Jaffe, MD, PhD (650) 723-6411 rajaffe@stanford.edu Principal Investigator: Mark A Burbridge, MD Sub-Investigator: Richard A Jaffe, MD, PhD Sub-Investigator: Jaime R Lopez, MD Collapse << |
| NCT01504711 | Gastrointestinal Cancer ... more >> Nausea Post Chemotherapy Collapse << | Not Applicable | Active, not recruiting | June 1, 2018 | United States, Michigan ... more >> Barbara Ann Karmanos Cancer Institute Detroit, Michigan, United States, 48201 Collapse << |
| NCT01074255 | - | - | Completed | - | - |
| NCT01594749 | - | - | Completed | - | - |
| NCT01074255 | - | - | Completed | - | - |
| NCT02407600 | Non-small Cell Lung Cancer ... more >> Vomiting Nausea Emesis Collapse << | Phase 2 | Unknown | February 2018 | United States, New York ... more >> SUNY Upstate Medical University Not yet recruiting Syracuse, New York, United States, 13210 Contact: Kristine Garcia, BS 315-464-5934 Contact: Dena Martin, BS 3154645262 Principal Investigator: Ajeet Gajra, MD FACP Collapse << |
| NCT01874119 | Chemotherapy-induced Nausea an... more >>d Vomiting Collapse << | Phase 2 | Terminated(Enrollment issues) | - | United States, Missouri ... more >> Saint Louis University Hospital Saint Louis, Missouri, United States, 63101 Collapse << |
| NCT01874119 | - | - | Terminated(Enrollment issues) | - | - |
| NCT01736917 | - | - | Completed | - | - |
| NCT01031953 | - | - | Terminated(Drug contract timel... more >>ines and inadequate enrollment) Collapse << | - | - |
| 靶点 | Description | IC50 |
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