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CAS No.: 6035-45-6
Synonyms: Leucovorin calcium salt pentahydrate;Folinic Acid;Leucovorin Calcium
Folinic acid is a reduced folic acid, which is used in combination with other chemotherapy drugs.
生物活性
动物研究 | |
剂量 | Mice: 7 mg/kg[3] (i.p.) |
给药途径 | i.p. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
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NCT00720109 | Adult B Acute Lymphoblastic Le... more >>ukemia With t(9;22)(q34;q11.2); BCR-ABL1 Childhood B Acute Lymphoblastic Leukemia With t(9;22)(q34;q11.2); BCR-ABL1 Untreated Adult Acute Lymphoblastic Leukemia Untreated Childhood Acute Lymphoblastic Leukemia Collapse << | Phase 2 Phase 3 | Completed | - | - |
NCT01256398 | Acute Lymphoblastic Leukemia ... more >> Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1 Untreated Adult Acute Lymphoblastic Leukemia Collapse << | Phase 2 | Active, not recruiting | - | - |
NCT00720109 | - | - | Completed | - | - |
实验方案
技术信息
CAS号 | 6035-45-6 | 储存条件 |
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分子式 | C20H31CaN7O12 | 运输 | 蓝冰 | |||||||||
分子量 | 601.58 | 别名 | Leucovorin calcium salt pentahydrate;Folinic Acid;Leucovorin Calcium;Leucovorin calcium hydrate;五水亚叶酸钙 | |||||||||
溶解度 |
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动物实验配方 |
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NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|
NCT00720109 | Adult B Acute Lymphoblastic Le... more >>ukemia With t(9;22)(q34;q11.2); BCR-ABL1 Childhood B Acute Lymphoblastic Leukemia With t(9;22)(q34;q11.2); BCR-ABL1 Untreated Adult Acute Lymphoblastic Leukemia Untreated Childhood Acute Lymphoblastic Leukemia Collapse << | Phase 2 Phase 3 | Completed | - | - |
NCT01256398 | Acute Lymphoblastic Leukemia ... more >> Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1 Untreated Adult Acute Lymphoblastic Leukemia Collapse << | Phase 2 | Active, not recruiting | - | - |
NCT00720109 | - | - | Completed | - | - |
NCT00792948 | - | - | Active, not recruiting | - | - |
NCT02101853 | B Acute Lymphoblastic Leukemia | Phase 3 | Recruiting | - | - |
NCT00792948 | Acute Lymphoblastic Leukemia ... more >> Adult Acute Lymphoblastic Leukemia in Remission Adult B Acute Lymphoblastic Leukemia Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1 Adult L1 Acute Lymphoblastic Leukemia Adult L2 Acute Lymphoblastic Leukemia Adult T Acute Lymphoblastic Leukemia Recurrent Adult Acute Lymphoblastic Leukemia Untreated Adult Acute Lymphoblastic Leukemia Collapse << | Phase 2 | Active, not recruiting | September 24, 2019 | - |
NCT02112916 | Adult T Acute Lymphoblastic Le... more >>ukemia Ann Arbor Stage II Adult Lymphoblastic Lymphoma Ann Arbor Stage II Childhood Lymphoblastic Lymphoma Ann Arbor Stage III Adult Lymphoblastic Lymphoma Ann Arbor Stage III Childhood Lymphoblastic Lymphoma Ann Arbor Stage IV Adult Lymphoblastic Lymphoma Ann Arbor Stage IV Childhood Lymphoblastic Lymphoma Childhood T Acute Lymphoblastic Leukemia Untreated Adult Acute Lymphoblastic Leukemia Untreated Childhood Acute Lymphoblastic Leukemia Collapse << | Phase 3 | Suspended(Other - Temporary cl... more >>osure) Collapse << | - | - |
NCT01190930 | Acute Lymphoblastic Leukemia ... more >> Adult B Lymphoblastic Lymphoma Ann Arbor Stage I B Lymphoblastic Lymphoma Ann Arbor Stage II B Lymphoblastic Lymphoma Childhood B Acute Lymphoblastic Leukemia Childhood B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1 Childhood B Lymphoblastic Lymphoma Down Syndrome Hypodiploid B Acute Lymphoblastic Leukemia Intrachromosomal Amplification of Chromosome 21 Philadelphia Chromosome Positive Untreated Adult Acute Lymphoblastic Leukemia Untreated Childhood Acute Lymphoblastic Leukemia Collapse << | Phase 3 | Active, not recruiting | - | - |
NCT02883049 | B Acute Lymphoblastic Leukemia... more >> Central Nervous System Leukemia Ph-Like Acute Lymphoblastic Leukemia Testicular Leukemia Untreated Adult Acute Lymphoblastic Leukemia Untreated Childhood Acute Lymphoblastic Leukemia Collapse << | Phase 3 | Recruiting | - | - |
NCT02730546 | Gastric Cardia Adenocarcinoma ... more >> Gastroesophageal Junction Adenocarcinoma Stage IB Gastric Cancer AJCC v7 Stage II Gastric Cancer AJCC v7 Stage IIA Gastric Cancer AJCC v7 Stage IIB Gastric Cancer AJCC v7 Stage IIIA Gastric Cancer AJCC v7 Stage IIIB Gastric Cancer AJCC v7 Collapse << | Phase 1 Phase 2 | Recruiting | April 15, 2021 | United States, Arizona ... more >> Mayo Clinic Hospital Recruiting Phoenix, Arizona, United States, 85054 Contact: Clinical Trials Referral Office 866-776-0015 Principal Investigator: Daniel H. Ahn United States, Minnesota Mayo Clinic Recruiting Rochester, Minnesota, United States, 55905 Contact: Clinical Trials Referral Office 855-776-0015 Principal Investigator: Harry H. Yoon Collapse << |
NCT00321685 | Rectal Adenocarcinoma ... more >> Stage II Rectal Cancer AJCC v7 Stage III Rectal Cancer AJCC v7 Collapse << | Phase 2 | Active, not recruiting | May 1, 2020 | - |
NCT00321685 | - | - | Active, not recruiting | - | - |
NCT02779283 | Acute Lymphoblastic Leukemia ... more >> Acute Myeloid Leukemia Collapse << | Phase 1 | Recruiting | June 1, 2019 | United States, Oregon ... more >> OHSU Knight Cancer Institute Recruiting Portland, Oregon, United States, 97239 Contact: Stephen E. Spurgeon 503-494-8950 spurgeos@ohsu.edu Principal Investigator: Stephen E. Spurgeon Collapse << |
NCT03007147 | B Acute Lymphoblastic Leukemia... more >> BCR-ABL1 Fusion Protein Expression Minimal Residual Disease Philadelphia Chromosome Positive T Acute Lymphoblastic Leukemia Untreated Adult Acute Lymphoblastic Leukemia Untreated Childhood Acute Lymphoblastic Leukemia Collapse << | Phase 3 | Recruiting | June 30, 2026 | - |
NCT02921256 | Rectal Adenocarcinoma ... more >> Stage II Rectal Cancer AJCC v7 Stage III Rectal Cancer AJCC v7 Collapse << | Phase 2 | Recruiting | - | - |
NCT02828358 | Acute Leukemia of Ambiguous Li... more >>neage Childhood B Acute Lymphoblastic Leukemia KMT2A Gene Rearrangement Mixed Phenotype Acute Leukemia Collapse << | Phase 2 | Suspended(Met accural pending ... more >>evaluation of enrolled pats.) Collapse << | September 30, 2019 | - |
NCT00408005 | T Acute Lymphoblastic Leukemia... more >> T Lymphoblastic Lymphoma Collapse << | Phase 3 | Completed | - | - |
NCT01959672 | Pancreatic Adenocarcinoma ... more >> Resectable Pancreatic Carcinoma Stage I Pancreatic Cancer Stage IA Pancreatic Cancer Stage IB Pancreatic Cancer Stage II Pancreatic Cancer Stage IIA Pancreatic Cancer Stage IIB Pancreatic Cancer Stage III Pancreatic Cancer Collapse << | Phase 2 | Active, not recruiting | December 2019 | United States, Nebraska ... more >> University of Nebraska Medical Center Omaha, Nebraska, United States, 68198 Collapse << |
NCT02997228 | Colorectal Adenocarcinoma ... more >> Mismatch Repair Deficiency Stage IV Colorectal Cancer AJCC v7 Stage IVA Colorectal Cancer AJCC v7 Stage IVB Colorectal Cancer AJCC v7 Collapse << | Phase 3 | Recruiting | April 30, 2022 | - |
NCT02896907 | Pancreatic Adenocarcinoma ... more >> Recurrent Pancreatic Carcinoma Stage III Pancreatic Cancer Stage IV Pancreatic Cancer Unresectable Pancreatic Carcinoma Collapse << | Early Phase 1 | Active, not recruiting | January 1, 2019 | United States, Pennsylvania ... more >> Sidney Kimmel Cancer Center at Thomas Jefferson University Philadelphia, Pennsylvania, United States, 19107 Collapse << |
NCT02620865 | Metastatic Pancreatic Adenocar... more >>cinoma Recurrent Pancreatic Carcinoma Stage III Pancreatic Cancer Stage IV Pancreatic Cancer Collapse << | Phase 1 Phase 2 | Active, not recruiting | December 2018 | United States, Michigan ... more >> Wayne State University/Karmanos Cancer Institute Detroit, Michigan, United States, 48201 Collapse << |
NCT01307956 | Adenocarcinoma of the Gastroes... more >>ophageal Junction Esophageal Adenocarcinoma Stage IIA Esophageal Cancer Stage IIB Esophageal Cancer Collapse << | Phase 2 | Terminated(Drug manufacturer -... more >> Amgen requested, per DSMB observation in POWER trial.) Collapse << | - | United States, Nebraska ... more >> University of Nebraska Medical Center Omaha, Nebraska, United States, 68198 Collapse << |
NCT01897454 | Pancreatic Adenocarcinoma ... more >> Stage IIA Pancreatic Cancer Stage IIB Pancreatic Cancer Stage III Pancreatic Cancer Collapse << | Phase 2 | Unknown | - | United States, New York ... more >> Montefiore Medical Center-Weiler Hospital Recruiting Bronx, New York, United States, 10461 Contact: Jennifer W. Chuy 718-405-8404 JCHUY@montefiore.org Principal Investigator: Jennifer W. Chuy Collapse << |
NCT03300609 | Colorectal Adenocarcinoma ... more >> RAS Wild Type Stage III Colorectal Cancer AJCC v7 Stage IIIA Colorectal Cancer AJCC v7 Stage IIIB Colorectal Cancer AJCC v7 Stage IIIC Colorectal Cancer AJCC v7 Stage IV Colorectal Cancer AJCC v7 Stage IVA Colorectal Cancer AJCC v7 Stage IVB Colorectal Cancer AJCC v7 Collapse << | Phase 3 | Recruiting | February 27, 2023 | United States, California ... more >> USC/Norris Comprehensive Cancer Center Recruiting Los Angeles, California, United States, 90033 Contact: Dana Agafitei 323-865-0467 Raluca.Agafitei@med.usc.edu Collapse << |
NCT01307956 | - | - | Terminated(Drug manufacturer -... more >> Amgen requested, per DSMB observation in POWER trial.) Collapse << | - | - |
NCT02890355 | Metastatic Pancreatic Adenocar... more >>cinoma Recurrent Pancreatic Carcinoma Stage IV Pancreatic Cancer AJCC v6 and v7 Collapse << | Phase 2 | Active, not recruiting | - | - |
NCT02912559 | Colon Adenocarcinoma ... more >> DNA Repair Disorder Lynch Syndrome Stage III Colon Cancer AJCC v7 Stage IIIA Colon Cancer AJCC v7 Stage IIIB Colon Cancer AJCC v7 Stage IIIC Colon Cancer AJCC v7 Collapse << | Phase 3 | Recruiting | July 1, 2020 | - |
NCT02042443 | - | - | Completed | - | - |
NCT02042443 | Adult Cholangiocarcinoma ... more >> Advanced Adult Hepatocellular Carcinoma BCLC Stage C Adult Hepatocellular Carcinoma BCLC Stage D Adult Hepatocellular Carcinoma Hilar Cholangiocarcinoma Localized Non-Resectable Adult Liver Carcinoma Recurrent Adult Liver Carcinoma Recurrent Childhood Liver Cancer Recurrent Extrahepatic Bile Duct Carcinoma Recurrent Gallbladder Carcinoma Stage II Gallbladder Cancer Stage III Childhood Hepatocellular Carcinoma Stage IIIA Gallbladder Cancer Stage IIIB Gallbladder Cancer Stage IV Childhood Hepatocellular Carcinoma Stage IV Distal Bile Duct Cancer Stage IVA Gallbladder Cancer Stage IVB Gallbladder Cancer Unresectable Extrahepatic Bile Duct Carcinoma Collapse << | Phase 2 | Completed | - | - |
NCT02508077 | Recurrent Colorectal Carcinoma... more >> Stage IVA Colorectal Cancer Stage IVB Colorectal Cancer Collapse << | Phase 2 | Terminated(Poor Accrual) | - | United States, California ... more >> City of Hope Medical Center Duarte, California, United States, 91010 City of Hope Antelope Valley Lancaster, California, United States, 93534 City of Hope Rancho Cucamonga Rancho Cucamonga, California, United States, 91730 South Pasadena Cancer Center South Pasadena, California, United States, 91030 Collapse << |
NCT02319018 | Malignant Digestive System Neo... more >>plasm Collapse << | Phase 1 | Completed | - | United States, Connecticut ... more >> Smilow Cancer Center/Yale-New Haven Hospital New Haven, Connecticut, United States, 06510 Yale University New Haven, Connecticut, United States, 06520 United States, Maryland Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore, Maryland, United States, 21287 United States, Michigan Wayne State University/Karmanos Cancer Institute Detroit, Michigan, United States, 48201 United States, Tennessee Vanderbilt University/Ingram Cancer Center Nashville, Tennessee, United States, 37232 Collapse << |
NCT01383343 | Recurrent Colon Carcinoma ... more >> Recurrent Rectal Carcinoma Stage IVA Colon Cancer Stage IVA Rectal Cancer Stage IVB Colon Cancer Stage IVB Rectal Cancer Collapse << | Phase 1 | Completed | - | United States, Arizona ... more >> Mayo Clinic in Arizona Scottsdale, Arizona, United States, 85259 United States, Florida Mayo Clinic in Florida Jacksonville, Florida, United States, 32224-9980 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 Collapse << |
NCT00957905 | Recurrent Extragonadal Seminom... more >>a Recurrent Malignant Extragonadal Germ Cell Tumor Recurrent Malignant Extragonadal Non-Seminomatous Germ Cell Tumor Recurrent Malignant Testicular Germ Cell Tumor Recurrent Ovarian Germ Cell Tumor Stage III Testicular Cancer Stage IV Extragonadal Non-Seminomatous Germ Cell Tumor Stage IV Extragonadal Seminoma Stage IV Ovarian Germ Cell Tumor Collapse << | Phase 2 | Completed | - | United States, California ... more >> Tower Cancer Research Foundation Beverly Hills, California, United States, 90211-1850 City of Hope Comprehensive Cancer Center Duarte, California, United States, 91010 USC / Norris Comprehensive Cancer Center Los Angeles, California, United States, 90033 University of California Davis Comprehensive Cancer Center Sacramento, California, United States, 95817 United States, Illinois University of Chicago Comprehensive Cancer Center Chicago, Illinois, United States, 60637 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 United States, New York Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10065 United States, Pennsylvania UPMC-Presbyterian Hospital Pittsburgh, Pennsylvania, United States, 15213 University of Pittsburgh Cancer Institute (UPCI) Pittsburgh, Pennsylvania, United States, 15232 United States, Wisconsin Riverview Hospital Wisconsin Rapids, Wisconsin, United States, 54494 Collapse << |
NCT02508077 | - | - | Terminated(Poor Accrual) | - | - |
NCT03337087 | Biliary System Disorder ... more >> BRCA1 Gene Mutation BRCA2 Gene Mutation Gastroesophageal Junction Adenocarcinoma Homologous Recombination Deficiency Metastatic Pancreatic Adenocarcinoma PALB2 Gene Mutation Stage IV Colorectal Cancer AJCC v7 Stage IV Pancreatic Cancer AJCC v6 and v7 Stage IVA Colorectal Cancer AJCC v7 Stage IVB Colorectal Cancer AJCC v7 Collapse << | Phase 1 Phase 2 | Not yet recruiting | December 31, 2022 | United States, Arizona ... more >> Mayo Clinic in Arizona Recruiting Scottsdale, Arizona, United States, 85259 Contact: Clinical Trial Referral Office 855-776-0015 Principal Investigator: Tanios S. Bekaii-Saab United States, Georgia Emory University Hospital/Winship Cancer Institute Not yet recruiting Atlanta, Georgia, United States, 30322 Contact: Christina S. Wu 404-778-0202 christina.wu@emoryhealthcare.org Principal Investigator: Christina S. Wu United States, Minnesota Mayo Clinic Not yet recruiting Rochester, Minnesota, United States, 55905 Contact: Clinical Trials Referral Office 855-776-0015 Principal Investigator: Wen Wee MA United States, Utah Huntsman Cancer Institute/University of Utah Not yet recruiting Salt Lake City, Utah, United States, 84112 Contact: Susan Sharry 801-585-3453 susan.sharry@hci.utah.edu Principal Investigator: Ignacio Garrido-Laguna Collapse << |
NCT00217737 | Colon Mucinous Adenocarcinoma ... more >> Colon Signet Ring Cell Adenocarcinoma Lynch Syndrome Stage IIA Colon Cancer AJCC v7 Stage IIB Colon Cancer AJCC v7 Stage IIC Colon Cancer AJCC v7 Collapse << | Phase 3 | Active, not recruiting | - | - |
NCT00957905 | - | - | Completed | - | - |
靶点 | Description | IC50 |
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