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CAS No.: 31430-15-6

Flubendazole/氟苯咪唑 Catalog No. CSN11023

Synonyms: Flumoxanal;NSC 313680;R-17889

Flubendazole is a potent broad spectrum anthelmintic.

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技术信息

生物活性

描述Flubendazole is a widely used anthelmintic drug belonging to benzimidazole group. The molecular mechanism of action of flubendazole is based on its specific binding to tubulin, which results in disruption of microtubule structure and function, and in the interference with the microtubule-mediated transport of secretory vesicles in absorptive tissues of helminths^[3]. In animals, flubendazole has good oral bioavailability from an ASD formulation ranging from 15% in dogs, 27% in rats to more than 100% in jirds. Regarding genotoxicity, flubendazole was negative in the Ames test, but positive in the in vivo micronucleus test^[4]. Flubendazole exerts anti-proliferation and pro-apoptosis effects in Glioma through affecting the cell cycle and intrinsic apoptotic signaling^[5]. Flubendazole is a novel small molecule inhibitor of not only melanoma growth and spread but also of PD-1(programmed cell death protein-1) and MDSC (myeloid-derived suppressor cell) ^[6]. Flubendazole inhibited the cell survival of different ESCC (esophageal squamous cell carcinoma) cells and induced cell apoptosis in both EC9706 and TE1 cells. In addition, flubendazole also showed a synergistic effect on ESCC cells when combined with doxorubicin^[7].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.1920 mL
- 15.9600 mL
- 31.9200 mL
- 5 mM
- 0.6384 mL
- 3.1920 mL
- 6.3840 mL
- 10 mM
- 0.3192 mL
- 1.5960 mL
- 3.1920 mL

技术信息

CAS号

31430-15-6

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C16H12FN3O3

运输

蓝冰

分子量

313.28

别名

Flumoxanal;NSC 313680;R-17889;R-17899;氟苯咪唑

溶解度

DMSO	5.0 mg/mL (16.0 mM) warming
Water	insoluble

动物实验配方

IP	2% DMSO+water	0.1 mg/mL	clear
PO	0.5% CMC-Na	36 mg/mL	suspension

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