|3-羟基-1-(4-甲氧基苯基)喹唑啉-2,4(1H,3H)-二酮|CsnPharm

CAS No.: 2109805-87-8

FEN1-IN-3 Catalog No. CSN20338

Synonyms: FEN1 Inhibitor C3

FEN1 inhibitor C3 is an inhibitor of flap endonuclease 1 (FEN1) which is required for proficient DNA replication and the repair of DNA damage.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述The structure-selective human flap endonuclease-1 (FEN1) is a metallonuclease that plays a key role in DNA replication and genome maintenance. Human FEN1 is overexpressed in multiple cancer types and therefore has been suggested as an oncology target. FEN1 inhibitor C3 stabilizes human FEN1 with an EC50 value of 6.8μM in an isothermal concentration-response experiment. FEN1 inhibitor C3 inhibits human FEN1-336Δ with an IC50 value of 16.9±1.2nM. It also exhibited cytotoxic against HeLa cells with an EC50 value of 6μM^[2].
参考文献

[1] Ward TA, McHugh PJ, Durant ST. Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes. PLoS One. 2017 Jun 19;12(6):e0179278.
[2] Exell JC, Thompson MJ, Finger LD, et al. Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site. Nat Chem Biol. 2016;12(10):815-821.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.5178 mL
- 17.5891 mL
- 35.1782 mL
- 5 mM
- 0.7036 mL
- 3.5178 mL
- 7.0356 mL
- 10 mM
- 0.3518 mL
- 1.7589 mL
- 3.5178 mL

技术信息

CAS号

2109805-87-8

储存条件

粉末: Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C15H12N2O4

运输

蓝冰

分子量

284.27

别名

FEN1 Inhibitor C3

溶解度

DMSO	240.0 mg/mL (844.3 mM) warming

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

FEN1-IN-3 Catalog No. CSN20338

靶点选择性

请登录您的专属账户

确认信息