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CAS No.: 298197-04-3
Synonyms: 125B11 hydrobromide;Fatostatin A;Fatostatin-A Hydrobromide
Fatostatin ia an inhibitor of sterol regulatory element binding protein (SREBP). It impairs the activation of SREBP-1 and SREBP-2.
生物活性
实验方案
技术信息
CAS号 | 298197-04-3 | 储存条件 |
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分子式 | C18H19BrN2S | 运输 | 蓝冰 | |||||
分子量 | 375.33 | 别名 | 125B11 hydrobromide;Fatostatin A;Fatostatin-A Hydrobromide;Fatostatin (hydrobromide);Fatostatin HBr;125B-11 | |||||
溶解度 |
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动物实验配方 |
Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
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CHO-K1 cells | - | Function assay | 20 h | Inhibition of SREBP2 activation expressed in CHO-K1 cells co-transfected with pSRE-Luc plasmid assessed as inhibition of luciferase expression after 20 hrs by luciferase reporter gene assay, IC50=5.6 μM | 21561152 |
mouse hepatocytes | 1 uM | Function assay | 90 mins | Metabolic stability in mouse hepatocytes at 1 uM after 90 mins by LC-MS/MS analysis | 21561152 |
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