生物活性

• 描述Ezatiostat hydrochloride is a glutathione analog inhibitor of glutathione S-transferase P1-1 (GSTP1-1).
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT00035867	Myelodysplastic Syndromes	Phase 1 Phase 2	Completed	-	United States, Alabama ... more >> University of Alabama at Birmingham Birmingham, Alabama, United States, 35294 United States, California The Angeles Clinic & Research Institute Los Angeles, California, United States, 90404 United States, Illinois University of Chicago Chicago, Illinois, United States, 60637 Midwest Cancer Research Group Skokie, Illinois, United States, 60077 United States, Oregon Oregon Health & Science University Portland, Oregon, United States, 97239 United States, Tennessee The Sarah Cannon Cancer Center Nashville, Tennessee, United States, 37203 United States, Texas Texas Cancer Associates Dallas, Texas, United States, 75231 M.D. Anderson Cancer Center Houston, Texas, United States, 77030 University of Texas Health Science Center at San Antonio San Antonio, Texas, United States, 78229 Collapse <<
  NCT00280631	Myelodysplastic Syndrome (MDS)	Phase 1 Phase 2	Completed	-	United States, Illinois ... more >> Loyola University Chicago-Cardinal Bernardin Cancer Center Maywood, Illinois, United States, 60153 Loyola University Medical Center Maywood, Illinois, United States, 60153 United States, Massachusetts University of Massachusetts (UMass) Memorial Medical Center Worcester, Massachusetts, United States, 01655 Collapse <<
  NCT01062152	Myelodysplastic Syndrome	Phase 1	Completed	-	United States, Arizona ... more >> Mayo Clinic Phoenix, Arizona, United States, 85054 United States, Illinois Loyola University Chicago Cardinal Benardin Cancer Center Maywood, Illinois, United States, 60153 United States, Maryland Center for Cancer and Blood Disorders Bethesda, Maryland, United States, 20817 United States, Massachusetts Dana Farber Cancer Institute Boston, Massachusetts, United States, 02115 United States, New York Columbia University Medical Center New York, New York, United States, 10032 University of Rochester Medical Center Rochester, New York, United States, 14642 United States, Ohio Cleveland Clinic Cleveland, Ohio, United States, 44195 United States, Texas MDAnderson Houston, Texas, United States, 77030 Cancer Care Centers of South Texas San Antonio, Texas, United States, 78229 Collapse <<

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• 参考文献

• [1] Raza A, Galili N, et al. Phase 1 dose-ranging study of ezatiostat hydrochloride in combination with lenalidomide in patients with non-deletion (5q) low to intermediate-1 risk myelodysplastic syndrome (MDS). J Hematol Oncol. 2012 Apr 30;5:18.

  [2] Raza A, Galili N, et al. Phase 1 multicenter dose-escalation study of ezatiostat hydrochloride (TLK199 tablets), a novel glutathione analog prodrug, in patients with myelodysplastic syndrome. Blood. 2009 Jun 25;113(26):6533-40.