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CAS No.: 22368-21-4

Eupatilin/泽兰林素 Catalog No. CSN13948

Synonyms: NSC 122413;异泽兰黄素

Eupatilin is an activiator of PPARα. It is a lipohilic flavonoid extracted from artemisia species with antioxidant, anti-tumor, and anti-inflammatory activities.

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纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Eupatilin (5,7-dihydroxy-3',4',6-trimethoxyflavone) is the main lipophilic flavonoid obtained from the Artemisia species. Eupatilin has been reported to have anti-apoptotic, anti-oxidative and anti-inflammatory activities. Eupatilin increases transcriptional activity and expression of peroxisome proliferator-activated receptor α (PPARα) in a keratinocyte cell line and acts as an agonist of PPARα. PPARα agonists ameliorate atopic dermatitis (AD) and restore the skin barrier function. Eupatilin (10, 30, 100 μM) suppresses IL-4 expression and degranulation in RBL-2H3 cells^[3]. Eupatilin inhibits TNFα(tumor necrosis factor-alpha)-induced MMP-2/-9 expression by suppressing NF-κB and MAPK⁄AP-1 pathways via PPARα^[4]. Eupatilin protected against H2O2-induced oxidative stress and apoptosis through the activation of PI3K/Akt signaling pathway in ARPE-19 cells^[5]. Eupatilin can inhibit IL-1β-induced apoptosis via sestrin2-dependent autophagy in chondrocytes^[6]. Eupatilin alleviated LPS(lipopolysaccharide)-induced ALI (acute lung injury) through inhibiting inflammation and oxidative stress in a concentration-dependent way, which was likely to be closely related with the activation of PPAR-alpha^[7].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.9043 mL
- 14.5216 mL
- 29.0431 mL
- 5 mM
- 0.5809 mL
- 2.9043 mL
- 5.8086 mL
- 10 mM
- 0.2904 mL
- 1.4522 mL
- 2.9043 mL

技术信息

CAS号

22368-21-4

储存条件

粉末: Keep in dark place,Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C18H16O7

运输

蓝冰

分子量

344.32

别名

NSC 122413;异泽兰黄素

溶解度

DMSO	68.0 mg/mL (197.5 mM)

动物实验配方

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