|(2R)-2-[6-(4-氯苯氧基)己基]环氧乙烷甲酸钠|CsnPharm

CAS No.: 828934-41-4

Etomoxir sodium salt Catalog No. CSN12803

Synonyms: (R)-(+)-Etomoxir sodium salt;(+)-Etomoxir (sodium salt);(R)-(+)-Etomoxir

(R)-(+)-etomoxir sodium salt is inhibitor of carnitine palmitoyltransferase I (CPT1) and can reduce β-oxidation in mitochondria. It shows inhibition of cardiolipin biosynthesis.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Oxidation of long-chain fatty acids inside of the mitochondrial matrix provides an essential source of energy for some cells. Since long-chain fatty acids cannot freely pass into the mitochondrial matrix, they rely on a protein called carnitine palmitoyltransferase I (CPT1) for transport. CPT1 has been identified as a potential therapeutic target for a growing list of cancers that include breast cancer, prostate cancer, glioblastoma, colon cancer, gastric cancer, myeloma, and others^[3]. (R)-(+)-etomoxir sodium salt is an inhibitor of carnitine palmitoyltransferase I (CPT1). Etomoxir at 10^-6 M prevented the palmitate-induced depression of function in heart but did not decrease myocardial long chain acylcarnitine or long chain acyl-CoA levels, and oxygen consumption per unit work was decreased during reperfusion recovery, and ATP and creatine-phosphate levels were significantly higher after reperfusion^[4]. 200 μM of etomoxir caused a significant reduction in cellular proliferation rate in BT549 cells, while 10 μM did not. 200 μM etomoxir treatment, however, significantly impaired mitochondrial respiration in BT549 cells, and a 65% decrease in basal respiration and a 65% decrease in maximal respiratory capacity after treating cells with 200 μM etomoxir was measured^[3]. Non-insulin-dependent diabetes mellitus (NIDDM) patients who received oral etomoxir treatment twice daily at the dose of 25 mg to 100 mg showed dose-dependent decrease in fasting blood glucose^[5].

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.1178 mL
- 15.5888 mL
- 31.1775 mL
- 5 mM
- 0.6236 mL
- 3.1178 mL
- 6.2355 mL
- 10 mM
- 0.3118 mL
- 1.5589 mL
- 3.1178 mL

技术信息

CAS号

828934-41-4

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C15H18ClNaO4

运输

蓝冰

分子量

320.74

别名

(R)-(+)-Etomoxir sodium salt;(+)-Etomoxir (sodium salt);(R)-(+)-Etomoxir;Etomoxir sodium;B 807-54

溶解度

DMSO	250.0 mg/mL (779.4 mM) warming
Water	45.0 mg/mL (140.3 mM) warming

动物实验配方

0.5% CMC-Na

30 mg/mL

suspension

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

Etomoxir sodium salt Catalog No. CSN12803

靶点选择性

请登录您的专属账户

确认信息