|丙酮酸乙酯|CsnPharm

CAS No.: 617-35-6

丙酮酸乙酯 Catalog No. CSN25169

Synonyms: CTI-01;丙酮酸乙酯

Ethyl pyruvate is a simple aliphatic ester of pyruvic acid and has been shown to have robust neuroprotective effects via its anti-inflammatory, anti-oxidative, and anti-apoptotic functions.

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400-920-2911

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技术信息

生物活性

描述Ethyl pyruvate is a simple derivative of the endogenous metabolite, pyruvic acid. Ethyl pyruvate was shown to ameliorate some of the structural and functional changes associated with mesenteric ischemia and reperfusion in rats^[1]. Administration of ethyl pyruvate protects mice against polymicrobial sepsis in cecal ligation and puncture (CLP) model. Ethyl pyruvate treatment significantly attenuated CLP-induced cognitive decline, microglia activation, and impaired neurogenesis. In addition, EP significantly decreased the NLRP3 level in the hippocampus of the CLP mice, and inhibited the cleavage of IL-1β induced by NLRP3 inflammsome in microglia^[2]. Ethyl pyruvate significantly decreased caspase-11 and gasdermin D-mediated pyroptosis induced by cytoplasmic lipopolysaccharide (LPS) and bacterial outer membrane vesicles (OMVs). Ethyl pyruvate treatment offered effective protection against lethal endotoxemia and reduced the release of IL-1α and IL-1β^[3]. Treatment with EP has been shown to improve survival and/or ameliorate organ dysfunction in a wide variety of preclinical models of critical illnesses, such as severe sepsis, acute respiratory distress syndrome, acute pancreatitis and stroke^[4].
参考文献

[1] Fink MP. Ethyl pyruvate. Curr Opin Anaesthesiol. 2008 Apr;21(2):160-7
[2] Zhong X, Xie L, Yang X, Liang F, Yang Y, Tong J, Zhong Y, Zhao K, Tang Y, Yuan C. Ethyl pyruvate protects against sepsis-associated encephalopathy through inhibiting the NLRP3 inflammasome. Mol Med. 2020 Jun 9;26(1):55
[3] Qiu X, Cheng X, Zhang J, Yuan C, Zhao M, Yang X. Ethyl pyruvate confers protection against endotoxemia and sepsis by inhibiting caspase-11-dependent cell pyroptosis. Int Immunopharmacol. 2020 Jan;78:106016
[4] Fink MP. Ethyl pyruvate: a novel anti-inflammatory agent. J Intern Med. 2007 Apr;261(4):349-62

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 8.6121 mL
- 43.0607 mL
- 86.1214 mL
- 5 mM
- 1.7224 mL
- 8.6121 mL
- 17.2243 mL
- 10 mM
- 0.8612 mL
- 4.3061 mL
- 8.6121 mL

技术信息

CAS号	617-35-6	储存条件	粉末 Inert atmosphere,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C5H8O3	运输	蓝冰
分子量	116.12	别名	CTI-01;丙酮酸乙酯

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