|2-氨基-6-氯-a-氰基-3-(乙氧羰基)-4H-1-苯并吡喃-4-乙酸乙酯|CsnPharm

CAS No.: 305834-79-1

Ethyl 2-amino-6-chloro-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate Catalog No. CSN16878

Synonyms: SC79

SC79 is a unique specific Akt activator that may be used to enhance Akt activity in various physiological and pathological conditions.

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纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Akt/PKB is the major molecular in the PI3K pathway. It contains a PH domain that specifically binds PtdIns(3,4,5)P3 on the plasma membrane, which guides AKT to the cell membrane in a process mediated by interaction with the phospholipids then switches AKT to an active form. Elevation of Akt activation is an obvious clinical strategy to prevent progressive neuronal death in neurological diseases. SC79 is a pan-Akt activator, though it suppresses AKT PH-domain plasma membrane translocation. In multiple cell lines, treatment with 1-4ug/ml SC79 can dramatically increase p-AKT. SC79 treatment (4μg/ml) can reduce the hippocampal neuron death induced by glutamate. Intraperitoneal injection of 40mg/kg SC79 can prevent stroke induced Akt deactivation and neuronal death in brain of mouse ischemia model. This also hinted that SC79 was brain-penetrable^[1].
作用机制SC79 can directly bind to AKT and convert AKT to an active conformation, which is more suitable to be phosphorylated by upstream kinases.^[1]
参考文献

[1] Jo H, Mondal S, et al. Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death. Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10581-6.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.7414 mL
- 13.7069 mL
- 27.4138 mL
- 5 mM
- 0.5483 mL
- 2.7414 mL
- 5.4828 mL
- 10 mM
- 0.2741 mL
- 1.3707 mL
- 2.7414 mL

技术信息

CAS号

305834-79-1

储存条件

粉末: Keep in dark place,Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C17H17ClN2O5

运输

蓝冰

分子量

364.78

别名

SC79

溶解度

DMSO	110.0 mg/mL (301.6 mM)
Water	insoluble

动物实验配方

2% DMSO+corn oil

5 mg/mL

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Ethyl 2-amino-6-chloro-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate Catalog No. CSN16878

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