|(S,S)-N,N'-双(1-羟基-2-丁基)乙二胺二盐酸盐|CsnPharm

CAS No.: 1070-11-7

Ethambutol 2HCl/盐酸乙胺丁醇 Catalog No. CSN18683

Synonyms: Emb dihydrochloride;CL 40881;Emb 2HCl

Ethambutol 2HCl is an antitubercular agent working by inhibiting the transfer of mycolic acids into the cell wall of the tubercle bacillus.

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技术信息

生物活性

描述Ethambutol dihydrochloride (Emb dihydrochloride) is a bacteriostatic antimycobacterial agent, which obstructs the formation of cell wall by inhibiting arabinosyl transferases. Antibacterial Ethambutol dihydrochloride (Emb dihydrochloride) directly affects two polymers, arabinogalactan (AG) and lipoarabinomannan (LAM) in Mycobacterium smegmatis^[3]. Ethambutol dihydrochloride (Emb dihydrochloride) is potent against M. tuberculosis (H37Rv) with MIC of 0.5 μg/mL in vitro^[4]. The % cell viability of A549 cells with all EDH (Ethambutol Dihydrochloride) formulations, pure EDH and chitosan carrier was higher than 80%, the calu-3 cell line had % viabilities of between 85 and 99%, and the % viability of NR8383 cells was between 81 and 100%. The pure EDH had a minimum inhibitory concentration (MIC) of 2 µg/mL while the EDH formulations had MIC values of less than 1 µg/mL when tested against M. bovis. The permeability of pure EDH across lipid bilayer was 48.7% after 2 h while in the EDH formulations it was enhanced to 71%^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.6071 mL
- 18.0355 mL
- 36.0709 mL
- 5 mM
- 0.7214 mL
- 3.6071 mL
- 7.2142 mL
- 10 mM
- 0.3607 mL
- 1.8035 mL
- 3.6071 mL

技术信息

CAS号

1070-11-7

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C10H26Cl2N2O2

运输

蓝冰

分子量

277.23

别名

Emb dihydrochloride;CL 40881;Emb 2HCl;Ethambutol (hydrochloride);Ethambutol Hydrochloride;CHEBI:4878;Ethambutol HCL;(+)-ethambutol dihydrochloride;(+)-(S,S)-ethambutol dihydrochloride;OR063209;Miambutol;Myambutol;EMB-Fatol;EMB-Hefa;盐酸乙胺丁醇

溶解度

DMSO	50.0 mg/mL (180.4 mM)
Water	30.0 mg/mL (108.2 mM)

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Ethambutol 2HCl/盐酸乙胺丁醇 Catalog No. CSN18683

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