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CAS No.: 140-67-0

Estragole/草蒿脑 Catalog No. CSN25431

Synonyms: 4-Allylanisole;Methyl Chavicol;NSC 404113

Estragole (4-Allylanisole), a relatively nontoxic volatile terpenoid ether, is a major component of the essential oil of many plants. Estragole dose-dependently blocks nerve excitability. Estragole displays anti-toxoplasma activity.

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描述Estragole (4-Allylanisole), a relatively nontoxic volatile terpenoid ether, is a major component of the essential oil of many plants. Estragole induced a dose-dependent blockade of the CAP (compound action potential). At 0.6 mM, estragole had no demonstrable effect. Estragole dose-dependently blocks nerve excitability^[3]. Estragole blocked the generation of action potentials in cells with or without inflexions on their descendant (repolarization) phase (Ninf and N0 neurons, respectively) in a concentration-dependent manner. Estragole also inhibited total Na+ current and tetrodotoxin-resistant Na+ current in a concentration-dependent manner (IC50 of 3.2 and 3.6 mM, respectively). Estragole blocks neuronal excitability by direct inhibition of Na+ channel conductance activation^[4]. Estragole displays anti-toxoplasma activity^[5]. Estragole induces apoptosis, but only with high doses (2000μM), and after long treatment periods (24h). Estragole, besides being metabolized to genotoxic metabolites, is a weak direct-acting genotoxin that forms DNA adducts^[6].
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实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 6.7476 mL
- 33.7378 mL
- 67.4756 mL
- 5 mM
- 1.3495 mL
- 6.7476 mL
- 13.4951 mL
- 10 mM
- 0.6748 mL
- 3.3738 mL
- 6.7476 mL

技术信息

CAS号	140-67-0	储存条件	粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C10H12O	运输	蓝冰
分子量	148.20	别名	4-Allylanisole;Methyl Chavicol;NSC 404113;草蒿脑;4-烯丙基苯甲醚

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