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CAS No.: 552-58-9

Eriodictyol/圣草酚 Catalog No. CSN12276

Synonyms: Huazhongilexone;圣草酚

Eriodictyol, a flavonoid isolated and purified from the fruits of Citrus sinensis (L.) Osbeck with anti-inflammatory and antioxidant activities, may possess antidiabetic properties through increasing glucose uptake and improving insulin resistance and be a potential therapeutic resource for Atopic dermatitis and an adjunctive agent to control itchiness in Atopic dermatitis.

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生物活性

描述Eriodictyol is a flavonoid extracted from the North American plant yerba santa, with antioxidant and anti-inflammatory activity. Eriodictyol shows protective effect against LPS-induced acute lung injury (ALI). Eriodictyol (30 mg/kg, p.o.) decreases the production of inflammatory cytokines, elevates survival rate, and decreases oxidative stress levels in LPS-induced ALI mice. Eriodictyol inhibits MPO activity and inflammatory neutrophil accumulation in the lung tissues. Eriodictyol treatment also enhances Trx1 expression by upregulating the Nrf2 expression in lung tissues^[3]. Eriodictyol (20, 40, 80 μM) protects primary cultured cortical neurons against Aβ25-35-induced cytotoxicity and cell apoptosis via the Nrf2/ARE pathway. Eriodictyol (80 μM) induces nuclear expression of Nrf2 and the expression of ARE-regulated genes in primary cultured cortical neurons^[4]. Eriodictyol dose- and time-dependently suppresses cell proliferation, migration, and invasion in U87MG and CHG-5 glioma cells. In addition, eriodictyol induces apoptosis in U87MG and CHG-5 cells. Furthermore, eriodictyol downregulates the phosphoinositide 3-kinase (PI3K)/Akt/NF-κB signaling pathway in a concentration-dependent manner^[5]. The proliferation rate of CNE1 cells was reduced in eriodictyol dose-dependently. Cell colonies were also observed to be minimised after eriodictyol exposure. Cell migration and invasion was significantly suppressed by eriodictyol in CNE1 cells^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03482401	Breast Cancer	Not Applicable	Active, not recruiting	June 1, 2019	Spain ... more >> Hospital General Universitario Reina Sofía Murcia, Spain, 30003 Collapse <<
NCT02627547	Healthy	Not Applicable	Completed	-	United Kingdom ... more >> University of Glasgow School of Medicine Glasgow, United Kingdom Collapse <<
NCT03215043	Pre Diabetes	Not Applicable	Recruiting	June 28, 2019	Brazil ... more >> Sao Paulo State University "Julio de Mesquita Filho", Faculdade de Ciências Farmacêuticas Recruiting Araraquara, Sao Paulo, Brazil, 14800-903 Contact: Thais B Cesar, Ph.D. +55 16 3301-6927 tcesar@fcfar.unesp.br Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.4692 mL
- 17.3459 mL
- 34.6918 mL
- 5 mM
- 0.6938 mL
- 3.4692 mL
- 6.9384 mL
- 10 mM
- 0.3469 mL
- 1.7346 mL
- 3.4692 mL

技术信息

CAS号

552-58-9

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C15H12O6

运输

蓝冰

分子量

288.25

别名

Huazhongilexone;圣草酚

溶解度

DMSO	57.0 mg/mL (197.7 mM)

动物实验配方

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Eriodictyol/圣草酚 Catalog No. CSN12276

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