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CAS No.: 84745-95-9

Eriocalyxin B Catalog No. CSN14581

Eriocalyxin B, a natural product isolated and purified from the herbs of Isodon eriocalyx, is a potent NF-kappaB inhibitor, can inhibit the NF-kappaB transcriptional activity but not that of cAMP response element-binding protein.

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400-920-2911

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描述Eriocalyxin B, a natural product isolated and purified from the herbs of Isodon eriocalyx, is a potent NF-kappaB inhibitor, can inhibit the NF-kappaB transcriptional activity but not that of cAMP response element-binding protein. Eriocalyxin B reversibly interfer with the binding of p65 and p50 subunits to the DNA in a noncompetitive manner, exerts potent antiinflammatory effects through selective modulation of pathogenic Th1 and Th17 cells by targeting critical signaling pathways, inhibits proliferation and induces apoptosis through downregulation of Bcl-2 and activation of caspase-3 in human bladder cancer cells and induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways, should be considered a candidate for pancreatic cancer treatment.
参考文献

[1] Yu X, He L, et al. Eriocalyxin B Inhibits STAT3 Signaling by Covalently Targeting STAT3 and Blocking Phosphorylation and Activation of STAT3. PLoS One. 2015 May 26;10(5):e0128406. doi: 10.1371/journal.pone.0128406. eCollection 2015.
[2] Li L, Yue GG, et al. Eriocalyxin B-induced apoptosis in pancreatic adenocarcinoma cells through thiol-containing antioxidant systems and downstream signalling pathways. Curr Mol Med. 2014;14(5):673-89.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.9036 mL
- 14.5179 mL
- 29.0359 mL
- 5 mM
- 0.5807 mL
- 2.9036 mL
- 5.8072 mL
- 10 mM
- 0.2904 mL
- 1.4518 mL
- 2.9036 mL

技术信息

CAS号	84745-95-9	储存条件	粉末 Keep in dark place,Sealed in dry,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C20H24O5	运输	蓝冰
分子量	344.40	别名

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