|(S,Z)-3-(2-((1R,3aS,7aR,E)-1-((2R,5S,E)-6-羟基-5,6-二甲基庚-3-烯-2-基)-7a-甲基八氢-4H-茚-4-亚基)亚乙基)-4-亚甲基环己-1-醇|CsnPharm

CAS No.: 21343-40-8

Synonyms: 25-hydroxy Vitamin D2;25-Hydroxyergocalciferol;25(OH)-Vitamin D2

Ercalcidiol is a metabolite of vitamin D2, is regarded as an indicator of vitamin D nutritional status.

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400-920-2911

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描述Ercalcidiol (25(OH)D2) is a metabolite of vitamin D2, is regarded as an indicator of vitamin D nutritional status. Differentiation between Ercalcidiol (25(OH)D2) and 25(OH)D3 is important for monitoring vitamin D therapy, as vitamin D2 is the predominant prescription form. The half-life of Ercalcidiol is shorter than that of 25(OH)D3 and it binds less well to the vitamin D binding protein, making it less potent and, therefore, required to be administered at much higher doses than vitamin D3. Some currently used assays have a diminished capacity to detect Ercalcidiol, which can lead to dangerous overdosing when attempting to monitor therapy with vitamin D2^[3]. The relations between magnesium treatment and plasma concentrations of 25(OH)D3, 25(OH)D2, and 24,25(OH)2D3 were significantly different dependent on the baseline concentrations of 25(OH)D, and significant interactions persisted after Bonferroni corrections^[4]. Administration of vitamin D2 reduces 25-hydroxylation of vitamin D3 and 1-α hydroxylation of 25(OH)D3, while increasing 24R-hydroxylation of 25(OH)D3^[5]. Blood spot and serum values showed excellent correlation for 25(OH)D(2) (R=0.90, n=54) and 25(OH)D(3) (R=0.91, n=83)^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02323295	Malignant Bone Tumors	Not Applicable	Recruiting	July 2019	United States, Massachusetts ... more >> Massachusetts General Hospital Recruiting Boston, Massachusetts, United States, 02114 Contact: Joseph Schwab, MD 617-643-2483 jhschwab@partners.org Principal Investigator: Joseph H. Schwab, MD Collapse <<
NCT03265483	Colorectal Cancer	Not Applicable	Completed	-	United States, Tennessee ... more >> Vanderbilt University Medical Center Nashville, Tennessee, United States, 37203 Collapse <<
NCT02525003	Serum 25-hydroxyvitamin D Conc... more >>entrations (25OHD) Collapse <<	Not Applicable	Completed	-	Finland ... more >> Department of Food and Environmental Sciences, University of Helsinki Helsinki, Finland Collapse <<

实验方案

技术信息

CAS号	21343-40-8	储存条件	粉末 Keep in dark place,Sealed in dry,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C28H44O2	运输	蓝冰
分子量	412.65	别名	25-hydroxy Vitamin D2;25-Hydroxyergocalciferol;25(OH)-Vitamin D2;25-Hydroxyecalciferol;25-Hydroxyvitamin D;25-OH Vitamin D2;25-羟基维生素;厄骨化二醇

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