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CAS No.: 5291-32-7
Synonyms: APR-246;PRIMA-1Met;APR 246. PRIMA-1MET
APR-246, is a small organic molecule that has been shown to restore tumour-suppressor function primarily to mutant p53 and also to induce cell death in various cancer types.
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生物活性
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
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NCT00900614 | Hematologic Neoplasms ... more >> Prostatic Neoplasms Collapse << | Phase 1 | Completed | - | Sweden ... more >> Section of Haematology and Coagulation, Sahlgrenska University Hospital Göteborg, Sweden, 41345 Hematology Centre, M54, Karolinska Institute, Karolinska University Hospital, Huddinge Stockholm, Sweden, SE 141 86 Clinical Research and Development Unit, Department of Oncology, Akademiska Hospital Uppsala, Sweden, 75185 Department of Haematology, Akademiska Hospital Uppsala, Sweden, 75185 Department of Hematology, University Hospital Örebro, Sweden, 70185 Urology clinic, University Hospital Örebro, Sweden, 70185 Collapse << |
NCT02098343 | Platinum Sensitive Recurrent H... more >>igh-grade Serous Ovarian Cancer With Mutated p53 Collapse << | Phase 1 Phase 2 | Active, not recruiting | - | - |
NCT03072043 | Myelodysplastic Syndrome ... more >> Acute Myeloid Leukemia Myeloproliferative Neoplasm Chronic Myelomonocytic Leukemia Collapse << | Phase 1 Phase 2 | Recruiting | May 2021 | United States, Florida ... more >> H. Lee Moffitt Cancer Center and Research Institute Recruiting Tampa, Florida, United States, 33612 Contact: Lisa Nardelli 813-745-4731 lisa.nardelli@moffitt.org Contact: David Sallman, M.D. 813-745-4673 david.sallman@moffit.org Principal Investigator: David Sallman, M.D. Sub-Investigator: Rami Komrokji, M.D. Sub-Investigator: Jeffrey Lancet, M.D. Sub-Investigator: Alan List, M.D. Sub-Investigator: Kathy McGraw, Ph.D. Sub-Investigator: Eric Padron, M.D. Sub-Investigator: Kendra Sweet, M.D. Sub-Investigator: Ling Zhang, M.D. Sub-Investigator: Rachid Baz, M.D. United States, Maryland The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Recruiting Baltimore, Maryland, United States, 21231 Contact: Amy DeZern, M.D. 410-502-7208 adezern1@jhmi.edu Principal Investigator: Amy DeZern, M.D. United States, Massachusetts Dana-Farber Cancer Institute Recruiting Boston, Massachusetts, United States, 02215 Contact: David Steensma, M.D. 617-632-5202 dsteensma@partners.org Principal Investigator: David Steensma, M.D. United States, New York Weill Medical College of Cornell University Recruiting New York, New York, United States, 10065 Contact: Finola Goudy 212-746-4447 fig4001@med.cornell.edu Principal Investigator: Gail Roboz, MD Sub-Investigator: Ellen Ritchie, MD Sub-Investigator: Sangmin Lee, MD Sub-Investigator: Pinkal Desai, MD Sub-Investigator: Michael Samuel, MD Sub-Investigator: Jeffrey Ball, MD Sub-Investigator: Sandra Allen-Bard, PA Sub-Investigator: Natalie Tafel, PA United States, Ohio Cleveland Clinic Taussig Cancer Center Recruiting Cleveland, Ohio, United States, 44195 Contact: Mikkael A. Sekeres, M.D. 216-445-9353 sekerem@ccf.org Principal Investigator: Mikkael A. Sekeres, M.D. United States, Texas University of Texas M.D. Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Contact: Heather Schneider, RN 713-792-4478 HNSchneider@mdanderson.or Principal Investigator: Guillermo Garcia-Manero, MD Collapse << |
实验方案
技术信息
CAS号 | 5291-32-7 | 储存条件 |
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分子式 | C10H17NO3 | 运输 | 蓝冰 | |||||
分子量 | 199.25 | 别名 | APR-246;PRIMA-1Met;APR 246. PRIMA-1MET | |||||
溶解度 |
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动物实验配方 |