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CAS No.: 152044-54-7
Synonyms: EPO 906;Patupilone;Epo B
Epothilone B is a microtubule stablizer which can promote tubulin polymerization.
生物活性
靶点 | Microtubule EC0.01:1.8μM |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|---|---|---|---|---|
NCT00077259 | Colorectal Cancer | Phase 2 | Completed | - | United States, New York ... more >> Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10021 Collapse << |
NCT00080301 | Breast Cancer ... more >> Metastases Collapse << | Phase 3 | Completed | - | - |
NCT00080301 | - | - | Completed | - | - |
实验方案
技术信息
CAS号 | 152044-54-7 | 储存条件 |
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分子式 | C27H41NO6S | 运输 | 蓝冰 | |||||||
分子量 | 507.68 | 别名 | EPO 906;Patupilone;Epo B;EPO 906A;埃博霉素B | |||||||
溶解度 |
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动物实验配方 |
Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
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human 639-V cell | - | Growth inhibition assay | - | Inhibition of human 639-V cell growth in a cell viability assay, IC50=0.218 μM | SANGER |
human 786-0 cell | - | Growth inhibition assay | - | Inhibition of human 786-0 cell growth in a cell viability assay, IC50=0.11 nM | SANGER |
human A375 cell | - | Growth inhibition assay | - | Inhibition of human A375 cell growth in a cell viability assay, IC50=5e-05 μM | SANGER |
human A388 cell | - | Growth inhibition assay | - | Inhibition of human A388 cell growth in a cell viability assay, IC50=0.94 μM | SANGER |
human A427 cell | - | Growth inhibition assay | - | Inhibition of human A427 cell growth in a cell viability assay, IC50=0.828 μM | SANGER |
human A431 cell | - | Growth inhibition assay | - | Inhibition of human A431 cell growth in a cell viability assay, IC50=9.86e-06 μM | SANGER |
human BB30-HNC cell | - | Growth inhibition assay | - | Inhibition of human BB30-HNC cell growth in a cell viability assay, IC50=0.201 μM | SANGER |
human Bel7402 | - | Proliferation assay | 72 h | Antiproliferative activity against human Bel7402 after 72 hrs by CellTiter Glo assay, IC50=0.9 μM | 22320354 |
human BFTC-905 cell | - | Growth inhibition assay | - | Inhibition of human BFTC-905 cell growth in a cell viability assay, IC50=4.99e-05 μM | SANGER |
human BHY cell | - | Growth inhibition assay | - | Inhibition of human BHY cell growth in a cell viability assay, IC50=0.195 nM | SANGER |
human CAL-12T cell | - | Growth inhibition assay | - | Inhibition of human CAL-12T cell growth in a cell viability assay, IC50=0.239 μM | SANGER |
human CAL-39 cell | - | Growth inhibition assay | - | Inhibition of human CAL-39 cell growth in a cell viability assay, IC50=0.411 μM | SANGER |
human COLO-679 cell | - | Growth inhibition assay | - | Inhibition of human COLO-679 cell growth in a cell viability assay, IC50=0.394 μM | SANGER |
human Daoy cell | - | Growth inhibition assay | - | Inhibition of human Daoy cell growth in a cell viability assay, IC50=2.73e-05 μM | SANGER |
human DU-145 cell | - | Growth inhibition assay | - | Inhibition of human DU-145 cell growth in a cell viability assay, IC50=0.721 μM | SANGER |
human ES1 cell | - | Growth inhibition assay | - | Inhibition of human ES1 cell growth in a cell viability assay, IC50=0.221 μM | SANGER |
human HCT-15 cell | - | Growth inhibition assay | - | Inhibition of human HCT-15 cell growth in a cell viability assay, IC50=0.717 μM | SANGER |
human HGC-27 cell | - | Growth inhibition assay | - | Inhibition of human HGC-27 cell growth in a cell viability assay, IC50=0.338 μM | SANGER |
human HLE cell | - | Growth inhibition assay | - | Inhibition of human HLE cell growth in a cell viability assay, IC50=8.26e-05 μM | SANGER |
human HMV-II cell | - | Growth inhibition assay | - | Inhibition of human HMV-II cell growth in a cell viability assay, IC50=0.394 μM | SANGER |
human HOS cell | - | Growth inhibition assay | - | Inhibition of human HOS cell growth in a cell viability assay, IC50=0.215 μM | SANGER |
human HSC-2 cell | - | Growth inhibition assay | - | Inhibition of human HSC-2 cell growth in a cell viability assay, IC50=0.363 nM | SANGER |
human HT-1080 cell | - | Growth inhibition assay | - | Inhibition of human HT-1080 cell growth in a cell viability assay, IC50=0.842 μM | SANGER |
human HUTU-80 cell | - | Growth inhibition assay | - | Inhibition of human HUTU-80 cell growth in a cell viability assay, IC50=0.328 μM | SANGER |
human IA-LM cell | - | Growth inhibition assay | - | Inhibition of human IA-LM cell growth in a cell viability assay, IC50=0.393 μM | SANGER |
human IGROV-1 cell | - | Growth inhibition assay | - | Inhibition of human IGROV-1 cell growth in a cell viability assay, IC50=0.156 μM | SANGER |
human KYSE-270 cell | - | Growth inhibition assay | - | Inhibition of human KYSE-270 cell growth in a cell viability assay, IC50=0.445 μM | SANGER |
human KYSE-450 cell | - | Growth inhibition assay | - | Inhibition of human KYSE-450 cell growth in a cell viability assay, IC50=0.267 μM | SANGER |
human KYSE-510 cell | - | Growth inhibition assay | - | Inhibition of human KYSE-510 cell growth in a cell viability assay, IC50=7.38e-05 μM | SANGER |
human LC-2-ad cell | - | Growth inhibition assay | - | Inhibition of human LC-2-ad cell growth in a cell viability assay, IC50=3.77e-06 μM | SANGER |
human LCLC-103H cell | - | Growth inhibition assay | - | Inhibition of human LCLC-103H cell growth in a cell viability assay, IC50=0.31 nM | SANGER |
human LCLC-97TM1 cell | - | Growth inhibition assay | - | Inhibition of human LCLC-97TM1 cell growth in a cell viability assay, IC50=0.444 μM | SANGER |
human LXF-289 cell | - | Growth inhibition assay | - | Inhibition of human LXF-289 cell growth in a cell viability assay, IC50=0.277 μM | SANGER |
human MCF7 cell | - | Growth inhibition assay | - | Inhibition of human MCF7 cell growth in a cell viability assay, IC50=8.66e-05 μM | SANGER |
human MG-63 cell | - | Growth inhibition assay | - | Inhibition of human MG-63 cell growth in a cell viability assay, IC50=0.165 μM | SANGER |
human NB13 cell | - | Growth inhibition assay | - | Inhibition of human NB13 cell growth in a cell viability assay, IC50=0.447 μM | SANGER |
human NCI-H1299 cell | - | Growth inhibition assay | - | Inhibition of human NCI-H1299 cell growth in a cell viability assay, IC50=0.88 μM | SANGER |
human NCI-H2009 cell | - | Growth inhibition assay | - | Inhibition of human NCI-H2009 cell growth in a cell viability assay, IC50=0.862 μM | SANGER |
human NCI-H2122 cell | - | Growth inhibition assay | - | Inhibition of human NCI-H2122 cell growth in a cell viability assay, IC50=0.41 μM | SANGER |
human NCI-H460 cell | - | Growth inhibition assay | - | Inhibition of human NCI-H460 cell growth in a cell viability assay, IC50=0.333 μM | SANGER |
human NCI-H650 cell | - | Growth inhibition assay | - | Inhibition of human NCI-H650 cell growth in a cell viability assay, IC50=0.17 μM | SANGER |
human NCI-H810 cell | - | Growth inhibition assay | - | Inhibition of human NCI-H810 cell growth in a cell viability assay, IC50=0.322 μM | SANGER |
human NH-12 cell | - | Growth inhibition assay | - | Inhibition of human NH-12 cell growth in a cell viability assay, IC50=0.891 μM | SANGER |
human PA-1 cell | - | Growth inhibition assay | - | Inhibition of human PA-1 cell growth in a cell viability assay, IC50=0.174 μM | SANGER |
human PANC-03-27 cell | - | Growth inhibition assay | - | Inhibition of human PANC-03-27 cell growth in a cell viability assay, IC50=0.132 μM | SANGER |
human PSN1 cell | - | Growth inhibition assay | - | Inhibition of human PSN1 cell growth in a cell viability assay, IC50=0.173 μM | SANGER |
human RKO cell | - | Growth inhibition assay | - | Inhibition of human RKO cell growth in a cell viability assay, IC50=6.47e-05 μM | SANGER |
human SCC-4 cell | - | Growth inhibition assay | - | Inhibition of human SCC-4 cell growth in a cell viability assay, IC50=0.877 μM | SANGER |
human SIG-M5 cell | - | Growth inhibition assay | - | Inhibition of human SIG-M5 cell growth in a cell viability assay, IC50=0.169 μM | SANGER |
human SK-LMS-1 cell | - | Growth inhibition assay | - | Inhibition of human SK-LMS-1 cell growth in a cell viability assay, IC50=0.646 μM | SANGER |
human SK-LU-1 cell | - | Growth inhibition assay | - | Inhibition of human SK-LU-1 cell growth in a cell viability assay, IC50=0.866 μM | SANGER |
human SK-UT-1 cell | - | Growth inhibition assay | - | Inhibition of human SK-UT-1 cell growth in a cell viability assay, IC50=0.892 μM | SANGER |
human ST486 cell | - | Growth inhibition assay | - | Inhibition of human ST486 cell growth in a cell viability assay, IC50=0.721 μM | SANGER |
human SW1710 cell | - | Growth inhibition assay | - | Inhibition of human SW1710 cell growth in a cell viability assay, IC50=2.14e-05 μM | SANGER |
human SW620 cell | - | Growth inhibition assay | - | Inhibition of human SW620 cell growth in a cell viability assay, IC50=0.648 μM | SANGER |
human SW954 cell | - | Growth inhibition assay | - | Inhibition of human SW954 cell growth in a cell viability assay, IC50=0.436 μM | SANGER |
human SW982 cell | - | Growth inhibition assay | - | Inhibition of human SW982 cell growth in a cell viability assay, IC50=0.999 μM | SANGER |
human T84 cell | - | Growth inhibition assay | - | Inhibition of human T84 cell growth in a cell viability assay, IC50=0.24 μM | SANGER |
human TE-15 cell | - | Growth inhibition assay | - | Inhibition of human TE-15 cell growth in a cell viability assay, IC50=0.225 μM | SANGER |
human TE-8 cell | - | Growth inhibition assay | - | Inhibition of human TE-8 cell growth in a cell viability assay, IC50=0.111 nM | SANGER |
human VMRC-RCZ cell | - | Growth inhibition assay | - | Inhibition of human VMRC-RCZ cell growth in a cell viability assay, IC50=0.136 μM | SANGER |
KB-31 cells | - | Growth inhibition assay | 72 h | Concentration required to inhibit the growth of paclitaxel-sensitive human epidermoid carcinoma cells KB-31 by 50 percent (72 hr exposure) | 11133086 |
KB-8511 cells | - | Growth inhibition assay | 72 h | Concentration required to inhibit the growth of paclitaxel-resistant human epidermoid carcinoma cells KB-8511 by 50 percent (72 hr exposure), IC50=0.18 μM | 11133086 |
ovarian carcinoma 1A9 cell | - | Growth inhibition assay | - | Inhibitory concentration against ovarian carcinoma 1A9 cell growth | 16134928 |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|
NCT00077259 | Colorectal Cancer | Phase 2 | Completed | - | United States, New York ... more >> Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10021 Collapse << |
NCT00080301 | Breast Cancer ... more >> Metastases Collapse << | Phase 3 | Completed | - | - |
NCT00080301 | - | - | Completed | - | - |
NCT00082433 | - | - | Completed | - | - |
NCT00977574 | Endometrial Adenocarcinoma ... more >> Endometrial Adenosquamous Carcinoma Endometrial Clear Cell Adenocarcinoma Endometrial Serous Adenocarcinoma Recurrent Uterine Corpus Carcinoma Stage IIIA Uterine Corpus Cancer AJCC v7 Stage IIIB Uterine Corpus Cancer AJCC v7 Stage IIIC Uterine Corpus Cancer AJCC v7 Stage IVA Uterine Corpus Cancer AJCC v7 Stage IVB Uterine Corpus Cancer AJCC v7 Collapse << | Phase 2 | Active, not recruiting | - | - |
NCT00977574 | - | - | Active, not recruiting | - | - |
NCT01375829 | Adult Solid Neoplasm | Phase 1 | Active, not recruiting | - | United States, Florida ... more >> Mayo Clinic in Florida Jacksonville, Florida, United States, 32224-9980 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 Collapse << |
NCT00785291 | - | - | Active, not recruiting | - | - |
NCT00082433 | Cancer Breast... more >> Cancer Collapse << | Phase 3 | Completed | - | - |
NCT01097642 | Breast Cancer | Phase 2 | Active, not recruiting | December 2019 | United States, Texas ... more >> The Methodist Hospital Cancer Center Houston, Texas, United States, 77030 Collapse << |
NCT00331344 | Adenocarcinoma of the Prostate... more >> Recurrent Prostate Cancer Stage IV Prostate Cancer Collapse << | Phase 1 Phase 2 | Completed | - | United States, California ... more >> UCSF Helen Diller Family Comprehensive Cancer Center San Francisco, California, United States, 94143-0875 United States, Wisconsin University of Wisconsin Hospital and Clinics Madison, Wisconsin, United States, 53792 Collapse << |
NCT00877500 | Bilateral Breast Carcinoma ... more >> HER2/Neu Negative Invasive Breast Carcinoma Collapse << | Phase 2 | Active, not recruiting | April 30, 2020 | United States, Illinois ... more >> Advocate Christ Medical Center Oak Lawn, Illinois, United States, 60453-2699 United States, Texas Lyndon Baines Johnson General Hospital Houston, Texas, United States, 77026-1967 M D Anderson Cancer Center Houston, Texas, United States, 77030 Collapse << |
NCT00331344 | - | - | Completed | - | - |
NCT00077376 | HER2-positive Breast Cancer ... more >> Male Breast Cancer Recurrent Breast Cancer Stage IV Breast Cancer Collapse << | Phase 2 | Completed | - | United States, Massachusetts ... more >> Eastern Cooperative Oncology Group Boston, Massachusetts, United States, 02215 Collapse << |
NCT00785291 | Estrogen Receptor Negative ... more >> Estrogen Receptor Positive HER2/Neu Negative HER2/Neu Positive Progesterone Receptor Negative Progesterone Receptor Positive Recurrent Breast Carcinoma Stage IIIC Breast Cancer AJCC v6 Stage IV Breast Cancer AJCC v6 and v7 Collapse << | Phase 3 | Active, not recruiting | - | - |
NCT00077376 | - | - | Completed | - | - |
NCT01084057 | Male Breast Cancer ... more >> Recurrent Breast Cancer Stage IV Breast Cancer Collapse << | Phase 1 | Active, not recruiting | June 2019 | United States, California ... more >> City of Hope Duarte, California, United States, 91010 South Pasadena Cancer Center South Pasadena, California, United States, 91030 Collapse << |
NCT00058084 | Adenocarcinoma of the Prostate... more >> Recurrent Prostate Cancer Stage IV Prostate Cancer Collapse << | Phase 2 | Completed | - | United States, California ... more >> UCSF Helen Diller Family Comprehensive Cancer Center San Francisco, California, United States, 94143-0875 Collapse << |
NCT01168232 | Recurrent Uterine Corpus Sarco... more >>ma Uterine Carcinosarcoma Collapse << | Phase 2 | Completed | - | - |
NCT01168232 | - | - | Completed | - | - |
NCT00182767 | Fallopian Tube Cancer ... more >> Female Reproductive Cancer Recurrent Breast Cancer Recurrent Ovarian Epithelial Cancer Stage III Ovarian Epithelial Cancer Stage IV Breast Cancer Stage IV Ovarian Epithelial Cancer Collapse << | Phase 1 Phase 2 | Completed | - | United States, Connecticut ... more >> University of Connecticut Farmington, Connecticut, United States, 06030 United States, New York Women's Cancer Care Associates LLC Albany, New York, United States, 12208 Albert Einstein College of Medicine Bronx, New York, United States, 10461 Montefiore Medical Center - Moses Campus Bronx, New York, United States, 10467-2490 Weill Medical College of Cornell University New York, New York, United States, 10065 Collapse << |
NCT00884676 | Unspecified Adult Solid Tumor,... more >> Protocol Specific Collapse << | Phase 1 | Completed | - | United States, Florida ... more >> University of Miami Sylvester Comprehensive Cancer Center Miami, Florida, United States, 33136 Collapse << |
NCT00182767 | - | - | Completed | - | - |
NCT00079326 | - | - | Terminated(Slow accrual.) | - | - |
NCT00079326 | HER2-positive Breast Cancer ... more >> Recurrent Breast Cancer Stage IV Breast Cancer Collapse << | Phase 2 | Terminated(Slow accrual.) | - | United States, Massachusetts ... more >> Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 Collapse << |
NCT01454479 | Recurrent Endometrial Cancer | Phase 1 | Unknown | April 2014 | - |
NCT00033618 | Metastatic Squamous Neck Cance... more >>r With Occult Primary Squamous Cell Carcinoma Recurrent Metastatic Squamous Neck Cancer With Occult Primary Recurrent Salivary Gland Cancer Recurrent Squamous Cell Carcinoma of the Hypopharynx Recurrent Squamous Cell Carcinoma of the Larynx Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity Recurrent Squamous Cell Carcinoma of the Oropharynx Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity Recurrent Verrucous Carcinoma of the Larynx Recurrent Verrucous Carcinoma of the Oral Cavity Salivary Gland Squamous Cell Carcinoma Stage IV Squamous Cell Carcinoma of the Hypopharynx Stage IVA Salivary Gland Cancer Stage IVA Squamous Cell Carcinoma of the Larynx Stage IVA Squamous Cell Carcinoma of the Lip and Oral Cavity Stage IVA Squamous Cell Carcinoma of the Oropharynx Stage IVA Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity Stage IVA Verrucous Carcinoma of the Larynx Stage IVA Verrucous Carcinoma of the Oral Cavity Stage IVB Salivary Gland Cancer Stage IVB Squamous Cell Carcinoma of the Larynx Stage IVB Squamous Cell Carcinoma of the Lip and Oral Cavity Stage IVB Squamous Cell Carcinoma of the Oropharynx Stage IVB Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity Stage IVB Verrucous Carcinoma of the Larynx Stage IVB Verrucous Carcinoma of the Oral Cavity Stage IVC Salivary Gland Cancer Stage IVC Squamous Cell Carcinoma of the Larynx Stage IVC Squamous Cell Carcinoma of the Lip and Oral Cavity Stage IVC Squamous Cell Carcinoma of the Oropharynx Stage IVC Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity Stage IVC Verrucous Carcinoma of the Larynx Stage IVC Verrucous Carcinoma of the Oral Cavity Tongue Cancer Collapse << | Phase 2 | Completed | - | United States, Massachusetts ... more >> Eastern Cooperative Oncology Group Boston, Massachusetts, United States, 02215 Collapse << |
NCT00045708 | Adult Anaplastic Astrocytoma ... more >> Adult Giant Cell Glioblastoma Adult Gliosarcoma Recurrent Adult Brain Tumor Collapse << | Phase 1 Phase 2 | Completed | - | United States, Georgia ... more >> Emory University Atlanta, Georgia, United States, 30322 United States, Maryland Johns Hopkins University Baltimore, Maryland, United States, 21287 United States, Massachusetts Massachusetts General Hospital Boston, Massachusetts, United States, 02114 United States, North Carolina Wake Forest University Winston-Salem, North Carolina, United States, 27157 United States, Ohio Cleveland Clinic Cleveland, Ohio, United States, 44106 Collapse << |
NCT00087139 | Adenocarcinoma of the Prostate... more >> Recurrent Prostate Cancer Stage IV Prostate Cancer Collapse << | Phase 2 | Completed | - | - |
NCT00087139 | - | - | Completed | - | - |
NCT00095979 | Endometrial Adenocarcinoma ... more >> Recurrent Endometrial Carcinoma Stage IV Endometrial Carcinoma Collapse << | Phase 2 | Completed | - | United States, Pennsylvania ... more >> Gynecologic Oncology Group Philadelphia, Pennsylvania, United States, 19103 Collapse << |
NCT00095979 | - | - | Completed | - | - |
NCT00025194 | Prostate Cancer | Phase 1 Phase 2 | Completed | - | United States, California ... more >> UCSF Comprehensive Cancer Center San Francisco, California, United States, 94115 United States, Massachusetts Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute Boston, Massachusetts, United States, 02115 United States, Michigan University of Michigan Comprehensive Cancer Center Ann Arbor, Michigan, United States, 48109-0942 United States, New York Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10021 Collapse << |
NCT00057850 | Head and Neck Cancer | Phase 1 Phase 2 | Completed | - | United States, Pennsylvania ... more >> Abramson Cancer Center of the University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104-4283 Collapse << |
NCT00030108 | Brain and Central Nervous Syst... more >>em Tumors Childhood Germ Cell Tumor Extragonadal Germ Cell Tumor Kidney Cancer Leukemia Liver Cancer Neuroblastoma Ovarian Cancer Sarcoma Unspecified Childhood Solid Tumor, Protocol Specific Collapse << | Phase 1 | Completed | - | United States, District of Col... more >>umbia Children's National Medical Center Washington, District of Columbia, United States, 20010-2970 United States, Maryland Warren Grant Magnuson Clinical Center - NCI Clinical Trials Referral Office Bethesda, Maryland, United States, 20892-1182 Collapse << |
NCT00045708 | - | - | Completed | - | - |
NCT00016393 | Prostate Cancer | Phase 2 | Completed | - | - |
NCT00030706 | Ovarian Cancer ... more >> Peritoneal Cavity Cancer Collapse << | Phase 2 | Completed | - | United States, New York ... more >> Albert Einstein Cancer Center at Albert Einstein College of Medicine Bronx, New York, United States, 10461 Collapse << |
NCT00045097 | Breast Cancer | Phase 2 | Completed | - | United States, Maryland ... more >> Suburban Hospital Bethesda, Maryland, United States, 20814 Oncology Care Associates Bethesda, Maryland, United States, 20817 Warren Grant Magnuson Clinical Center - NCI Clinical Studies Support Bethesda, Maryland, United States, 20892-1182 NCI - Center for Cancer Research Bethesda, Maryland, United States, 20892 Collapse << |
NCT00016965 | Pancreatic Cancer | Phase 2 | Completed | - | - |
NCT00020904 | Breast Cancer | Phase 2 | Completed | - | United States, New York ... more >> Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10021 Herbert Irving Comprehensive Cancer Center New York, New York, United States, 10032 Collapse << |
NCT00182702 | Clear Cell Renal Cell Carcinom... more >>a Recurrent Renal Cell Cancer Stage III Renal Cell Cancer Stage IV Renal Cell Cancer Collapse << | Phase 2 | Completed | - | United States, Illinois ... more >> University of Chicago Comprehensive Cancer Center Chicago, Illinois, United States, 60637-1470 Collapse << |
NCT00005807 | Breast Cancer ... more >> Ovarian Cancer Unspecified Adult Solid Tumor, Protocol Specific Collapse << | Phase 1 | Completed | - | United States, New York ... more >> Albert Einstein Clinical Cancer Center Bronx, New York, United States, 10461 NYU School of Medicine's Kaplan Comprehensive Cancer Center New York, New York, United States, 10016 Collapse << |
NCT00022477 | Colorectal Cancer | Phase 2 | Completed | - | United States, Illinois ... more >> University of Illinois at Chicago Chicago, Illinois, United States, 60612 University of Chicago Cancer Research Center Chicago, Illinois, United States, 60637-1470 Louis A. Weiss Memorial Hospital Chicago, Illinois, United States, 60640 Decatur Memorial Hospital Cancer Care Institute Decatur, Illinois, United States, 62526 Evanston Northwestern Health Care Evanston, Illinois, United States, 60201 Ingalls Memorial Hospital Harvey, Illinois, United States, 60426 LaGrange Memorial Hospital LaGrange, Illinois, United States, 60525 Loyola University Medical Center Maywood, Illinois, United States, 60153 Lutheran General Cancer Care Center Park Ridge, Illinois, United States, 60068 Oncology/Hematology Associates of Central Illinois, P.C. Peoria, Illinois, United States, 61602 Central Illinois Hematology Oncology Center Springfield, Illinois, United States, 62701 United States, Indiana Fort Wayne Medical Oncology and Hematology, Inc. Fort Wayne, Indiana, United States, 46885-5099 Michiana Hematology/Oncology P.C. South Bend, Indiana, United States, 46601 United States, Michigan Lakeland Medical Center - St. Joseph Saint Joseph, Michigan, United States, 49085 United States, New York Albert Einstein Comprehensive Cancer Center Bronx, New York, United States, 10461 Collapse << |
NCT00924066 | - | - | Completed | - | - |
NCT00028561 | Unspecified Adult Solid Tumor,... more >> Protocol Specific Collapse << | Phase 1 | Terminated(Administratively co... more >>mplete.) Collapse << | - | United States, Florida ... more >> H. Lee Moffitt Cancer Center and Research Institute Tampa, Florida, United States, 33612 Collapse << |
NCT00049400 | Lymphoma Smal... more >>l Intestine Cancer Unspecified Adult Solid Tumor, Protocol Specific Collapse << | Phase 1 | Completed | - | United States, California ... more >> City of Hope Comprehensive Cancer Center Duarte, California, United States, 91010-3000 USC/Norris Comprehensive Cancer Center and Hospital Los Angeles, California, United States, 90089-9181 University of California Davis Cancer Center Sacramento, California, United States, 95817 United States, Illinois Cardinal Bernardin Cancer Center at Loyola University Medical Center Maywood, Illinois, United States, 60153 United States, Kansas Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center Kansas City, Kansas, United States, 66160-7357 United States, Ohio Case Comprehensive Cancer Center Cleveland, Ohio, United States, 44106 Cleveland Clinic Taussig Cancer Center Cleveland, Ohio, United States, 44195 Community Oncology Group at Cleveland Clinic Cancer Center Independence, Ohio, United States, 44131 Cleveland Clinic - Wooster Wooster, Ohio, United States, 44691 United States, Texas Brooke Army Medical Center Fort Sam Houston, Texas, United States, 78234 Wilford Hall Medical Center Lackland AFB, Texas, United States, 78236 University of Texas Health Science Center at San Antonio San Antonio, Texas, United States, 78229-3900 United States, Washington St. Joseph Hospital Community Cancer Center Bellingham, Washington, United States, 98225 Olympic Hematology and Oncology Bremerton, Washington, United States, 98310 Skagit Valley Hospital Cancer Care Center Mt. Vernon, Washington, United States, 98273 Group Health Central Hospital Seattle, Washington, United States, 98104-1387 Fred Hutchinson Cancer Research Center Seattle, Washington, United States, 98104 Harborview Medical Center Seattle, Washington, United States, 98104 Swedish Cancer Institute at Swedish Medical Center - First Hill Campus Seattle, Washington, United States, 98122-4307 University Cancer Center at University of Washington Medical Center Seattle, Washington, United States, 98195-6043 North Puget Oncology at United General Hospital Sedro-Wooley, Washington, United States, 98284 Cancer Care Northwest - Spokane South Spokane, Washington, United States, 99202 Wenatchee Valley Medical Center Wenatchee, Washington, United States, 98801-2028 Collapse << |
NCT00030992 | Renal Cell Carcinoma | Phase 2 | Completed | - | United States, Maryland ... more >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Collapse << |
NCT00036764 | Recurrent Melanoma ... more >> Stage IV Melanoma Collapse << | Phase 2 | Completed | - | United States, New York ... more >> New York University Clinical Cancer Center New York, New York, United States, 10016-4760 Collapse << |
NCT00052572 | Leukemia Lymp... more >>homa Collapse << | Phase 2 | Completed | - | United States, New York ... more >> Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10021 United States, Vermont Vermont Cancer Center at University of Vermont Burlington, Vermont, United States, 05401-3498 Collapse << |
NCT00025155 | Primary Peritoneal Cavity Canc... more >>er Recurrent Ovarian Epithelial Cancer Collapse << | Phase 2 | Completed | - | United States, Pennsylvania ... more >> Gynecologic Oncology Group Philadelphia, Pennsylvania, United States, 19103 Collapse << |
NCT00025155 | - | - | Completed | - | - |
NCT00058019 | Anaplastic Large Cell Lymphoma... more >> Recurrent Adult Burkitt Lymphoma Recurrent Adult Diffuse Large Cell Lymphoma Recurrent Adult Diffuse Mixed Cell Lymphoma Recurrent Grade 3 Follicular Lymphoma Recurrent Mantle Cell Lymphoma Collapse << | Phase 2 | Completed | - | United States, Illinois ... more >> University of Chicago Chicago, Illinois, United States, 60637 United States, Texas M D Anderson Cancer Center Houston, Texas, United States, 77030 Collapse << |
NCT00030992 | - | - | Completed | - | - |
NCT00331643 | Adult Rhabdomyosarcoma ... more >> Adult Synovial Sarcoma Alveolar Childhood Rhabdomyosarcoma Childhood Synovial Sarcoma Embryonal Childhood Rhabdomyosarcoma Previously Treated Childhood Rhabdomyosarcoma Recurrent Adult Soft Tissue Sarcoma Recurrent Childhood Rhabdomyosarcoma Recurrent Childhood Soft Tissue Sarcoma Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor Recurrent Neuroblastoma Recurrent Osteosarcoma Recurrent Wilms Tumor and Other Childhood Kidney Tumors Collapse << | Phase 2 | Completed | - | United States, California ... more >> Children's Oncology Group Arcadia, California, United States, 91006-3776 Collapse << |
NCT00058019 | - | - | Completed | - | - |
NCT00924066 | Cervical Carcinoma ... more >> Cervical Adenocarcinoma Cervical Adenosquamous Carcinoma Cervical Carcinoma, Non-SquamousType Collapse << | Phase 2 | Completed | - | United States, Maryland ... more >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Collapse << |
NCT00022542 | Recurrent Adult Soft Tissue Sa... more >>rcoma Stage III Adult Soft Tissue Sarcoma Stage IV Adult Soft Tissue Sarcoma Collapse << | Phase 2 | Terminated | - | United States, Minnesota ... more >> Mayo Clinic Rochester, Minnesota, United States, 55905 Collapse << |
NCT00023946 | Adult Primary Cholangiocellula... more >>r Carcinoma Adult Primary Hepatocellular Carcinoma Advanced Adult Primary Liver Cancer Cholangiocarcinoma of the Extrahepatic Bile Duct Cholangiocarcinoma of the Gallbladder Localized Extrahepatic Bile Duct Cancer Localized Gallbladder Cancer Localized Resectable Adult Primary Liver Cancer Localized Unresectable Adult Primary Liver Cancer Recurrent Adult Primary Liver Cancer Recurrent Extrahepatic Bile Duct Cancer Recurrent Gallbladder Cancer Unresectable Extrahepatic Bile Duct Cancer Unresectable Gallbladder Cancer Collapse << | Phase 2 | Terminated | - | United States, Illinois ... more >> University of Chicago Chicago, Illinois, United States, 60637 Collapse << |
NCT00407251 | Hormone Refractory Prostate Ca... more >>ncer Collapse << | Phase 2 | Completed | - | Canada, Alberta ... more >> Tom Baker Cancer Centre Calgary, Alberta, Canada, T4N 4N2 Canada, British Columbia BC Cancer Agency - Vancouver Centre Vancouver, British Columbia, Canada, V5Z 4E6 Canada, Ontario Juravinski Cancer Centre Hamilton, Ontario, Canada, L8B 5C2 London Health Sciences Centre London, Ontario, Canada, N6A 4L6 Princess Margaret Hospital Toronto, Ontario, Canada, M5G 2M9 Collapse << |
NCT00411528 | Metastatic Hormone Refractory ... more >>Prostate Cancer Collapse << | Phase 2 | Completed | - | - |
NCT00021099 | Distal Urethral Cancer ... more >> Metastatic Transitional Cell Cancer of the Renal Pelvis and Ureter Proximal Urethral Cancer Recurrent Bladder Cancer Recurrent Transitional Cell Cancer of the Renal Pelvis and Ureter Recurrent Urethral Cancer Regional Transitional Cell Cancer of the Renal Pelvis and Ureter Stage III Bladder Cancer Stage IV Bladder Cancer Transitional Cell Carcinoma of the Bladder Urethral Cancer Associated With Invasive Bladder Cancer Collapse << | Phase 2 | Completed | - | United States, Massachusetts ... more >> Eastern Cooperative Oncology Group Boston, Massachusetts, United States, 02215 Collapse << |
NCT00421044 | Advanced Malignancies ... more >> Tumors Collapse << | Phase 1 | Completed | - | United States, California ... more >> University of California San Diego/Moores Cancer Center La Jolla, California, United States, 92093-0987 United States, Texas Institute for Drug Development Cancer Therapy & Research Center/The University of Texas Health Science Center San Antonio, Texas, United States, 78229 South Texas Accelerated Research Therapeutics San Antonio, Texas, United States, 78229 Collapse << |
NCT00035087 | Colorectal Neoplasms ... more >> Colonic Neoplasms Collapse << | Phase 2 | Completed | - | United States, New Jersey ... more >> Cancer Institute of New Jersey (CINJ) New Brunswick, New Jersey, United States, 08901 Collapse << |
NCT00035113 | Prostatic Neoplasms | Phase 2 | Completed | - | United States, California ... more >> Pacific Shores Medical Group Long Beach, California, United States, 90813 California Pacific Medical Center San Francisco, California, United States, 94115 United States, Maryland University of Maryland - Greenbaum Cancer Center Baltimore, Maryland, United States, 21201 United States, New Jersey Cancer Institute of New Jersey (CINJ) New Brunswick, New Jersey, United States, 08901 United States, Washington Seattle Cancer Care Alliance Seattle, Washington, United States, 98109 Collapse << |
NCT00468260 | Advanced Malignancies | Phase 1 | Terminated(pts. will be captur... more >>ed in core) Collapse << | - | United States, Texas ... more >> San Antonio, Texas, United States Collapse << |
NCT00715013 | Recurrent Glioblastoma Planned... more >> for Reoperation Collapse << | Phase 1 Phase 2 | Completed | - | - |
NCT00035126 | Breast Neoplasms | Phase 2 | Completed | - | United States, New Hampshire ... more >> Dartmouth Hitchcock Medical Center Lebanon, New Hampshire, United States, 03756 United States, New Jersey Cancer Institute of New Jersey (CINJ) New Brunswick, New Jersey, United States, 08901 Collapse << |
NCT00420524 | Advanced Malignancies ... more >> Tumors Collapse << | Phase 1 | Completed | - | United States, California ... more >> University of California San Diego/Moores Cancer Center La Jolla, California, United States, 92093-0987 United States, New Mexico Cancer Research and Treatment Center Albuquerque, New Mexico, United States, 87131-5636 United States, Texas Institute for Drug Development Cancer Therapy & Research Center/The University of Texas Health Science San Antonio, Texas, United States, 78229 South Texas Accelerated Research Therapeutics San Antonio, Texas, United States, 78229 Collapse << |
NCT00496600 | Refractory Malignancy | Phase 1 | Completed | - | United States, New Jersey ... more >> The Cancer Institute of New Jersey New Brunswick, New Jersey, United States, 08901 Collapse << |
NCT00035243 | Kidney Neoplasms | Phase 2 | Completed | - | United States, California ... more >> UCLA Medical Center Los Angeles, California, United States, 90095 United States, Maryland University of Maryland Baltimore, Maryland, United States, 21201 United States, Michigan Wayne State University Karmanos Cancer Center Detroit, Michigan, United States, 48201 United States, New York Our Lady Of Mercy Medical Center Bronx, New York, United States, 10466 United States, Ohio Cleveland Clinic Foundation Cleveland, Ohio, United States, 44195 United States, Washington University of Washington Seattle, Washington, United States, 98109 France Centre L. Berard Lyon, France Institut Gustave Roussy Villejuif, France Collapse << |
NCT00426140 | Advanced Malignancies ... more >> Solid Tumors Collapse << | Phase 1 | Completed | - | United States, Texas ... more >> Cancer Therapy and Research Center, Institution for Drug Development San Antonio, Texas, United States, 78229 Collapse << |
NCT00442741 | Solid Tumors | Phase 1 | Withdrawn(pts. will be capture... more >>d in core) Collapse << | - | - |
NCT00159484 | Colon Cancer ... more >>Colorectal Cancer Collapse << | Phase 1 Phase 2 | Active, not recruiting | December 2017 | United States, California ... more >> U.S.C./Norris Comprehensive Cancer Center Los Angeles, California, United States, 90033 Collapse << |
NCT00262990 | Ovarian Cancer ... more >> Fallopian Tube Cancer Peritoneal Neoplasms Collapse << | Phase 3 | Completed | - | - |
NCT00448396 | Advanced Malignancies | Phase 1 | Completed | - | United States, Texas ... more >> San Antonio, Texas, United States Collapse << |
NCT00426582 | Advanced Solid Tumors | Phase 1 | Completed | - | United States, Connecticut ... more >> Norwalk Hospital Norwalk, Connecticut, United States, 06856 United States, Maryland Associates in Oncology Rockville, Maryland, United States, 20850 United States, Michigan Wertz Clinical Cancer Center (Wayne State University) Detroit, Michigan, United States, 48201 United States, Missouri Siteman Cancer Center (Washington University School of Medicine) St. Louis, Missouri, United States, 63110-1093 United States, New Mexico Cancer Research and Treatment Center (University of New Mexico) Albuquerque, New Mexico, United States, 87131 Collapse << |
NCT00328458 | Central Nervous System Neoplas... more >>ms Head and Neck Neoplasms Collapse << | Phase 1 | Completed | - | United States, Pennsylvania ... more >> Thomas Jefferson University Hospital Philadelphia, Pennsylvania, United States, 19107 Collapse << |
NCT00035165 | Melanoma | Phase 2 | Completed | - | United States, Colorado ... more >> University of Colorado Aurora, Colorado, United States, 80045 United States, Florida H. Lee Moffitt Cancer Center and Research Institute Tampa, Florida, United States, 33612 United States, New York Comprehensive Cancer Center@ Our Lady if Mercy Medical Center Bronx, New York, United States, 10466-2697 United States, North Carolina Duke University Medical Center Durham, North Carolina, United States, 27710 United States, Oklahoma Oklahoma Oncology, Inc. Tulsa, Oklahoma, United States, 74104 United States, Pennsylvania UPMC Health Systems Pittsburgh, Pennsylvania, United States, 15213 Collapse << |
NCT00035100 | Ovarian Neoplasms ... more >> Peritoneal Neoplasms Fallopian Tube Neoplasms Collapse << | Phase 2 | Completed | - | United States, New Jersey ... more >> Novartis Investigative Site New Brunswick, New Jersey, United States, 08901 Canada, Ontario Novartis Investigative Site Toronto, Ontario, Canada, M5G 2M9 Netherlands Novartis Investigative Site Amsterdam, Netherlands, 1066 CX Novartis Investigative Site Enschede, Netherlands, 7513 ER Novartis Investigative Site Zwolle, Netherlands, 8025 AB Slovakia Novartis Investigative Site Bratislava, Slovakia, 812 50 Novartis Investigative Site Kosice, Slovakia, 04190 United Kingdom Novartis Investigative Site Surrey, United Kingdom, SM2 5PT Collapse << |
NCT00273312 | Hepatocellular Carcinoma | Phase 2 | Completed | - | United States, California ... more >> Novartis Investigative Site San Francisco, California, United States, 94115 Hong Kong Novartis Investigative Site Hong Kong, Shatin, NT, Hong Kong Novartis Investigative Site Hong Kong, Hong Kong Korea, Republic of Novartis Investigative Site Seoul, Korea, Korea, Republic of, 110 744 Novartis Investigative Site Seoul, Korea, Republic of, 738-736 Taiwan Novartis Investigative Site Taipei, Taiwan ROC, Taiwan, 100 Novartis Investigative Site Tai Chung Municipality, Taiwan Collapse << |
NCT00219297 | Brain Metastasis ... more >> Non-small Cell Lung Cancer Collapse << | Phase 2 | Completed | - | United States, California ... more >> University of California Davis Cancer Center Dept. of UC Davis Cancer (3) Sacramento, California, United States, 95817 United States, Massachusetts Dana Farber Cancer Institute SC Boston, Massachusetts, United States, 02115 United States, Michigan Wayne State University/Wertz Clinical Cancer Center Div. of Hematology/Oncology Detroit, Michigan, United States, 48201 United States, Missouri St. Louis University Cancer Center St. Louis, Missouri, United States, 63110 Washington University School of Medicine-Siteman Cancer Ctr St. Louis, Missouri, United States, 63110 United States, New Hampshire Dartmouth Hitchcock Medical Center Oncology Lebanon, New Hampshire, United States, 03756 United States, New York Roswell Park Cancer Institute Buffalo, New York, United States, 14263 Memorial Sloan Kettering Cancer Center New York, New York, United States, 10022 Columbia University Medical Center- New York Presbyterian New York, New York, United States, 10032 United States, North Carolina Duke University Medical Center Dept. of DUMC (3) Durham, North Carolina, United States, 27710 United States, Ohio Cleveland Clinic Foundation Cleveland, Ohio, United States, 44195 United States, Wisconsin University of Wisconsin Hospital and Clinics Madison, Wisconsin, United States, 53792 Collapse << |
NCT00420615 | Solid Tumors | Phase 1 | Completed | - | United States, Texas ... more >> The University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Collapse << |
NCT00171834 | - | - | Completed | - | - |
NCT00050349 | Carcinoid Neu... more >>roendocrine Tumors Collapse << | Phase 2 | Completed | - | United States, Illinois ... more >> Northwestern University Chicago, Illinois, United States, 60611 United States, Iowa University of Iowa Health Care Iowa City, Iowa, United States, 52242-1091 United States, Louisiana LSU HEALTH SCIENCES CENTER/ LSU SCHOOL OF MEDICINE Deptof LSU Health Sciences (2) New Orleans, Louisiana, United States, 70115 United States, New York Weill Medical College of Cornell Univ. New York, New York, United States, 10021 United States, Oregon Oregon Health Sciences University Portland, Oregon, United States, 97201 Collapse << |
NCT00171834 | Carcinoma, Non-Small-Cell Lung | Phase 1 Phase 2 | Completed | - | United States, Kentucky ... more >> Norton Healthcare/Hospital Inc Louisville, Kentucky, United States, 40232-5070 United States, Missouri Ellis Fisher Cancer Center Columbia, Missouri, United States, 65203 United States, Pennsylvania Hillman Cancer Center Pittsburg, Pennsylvania, United States, 15232 United States, Texas MD Anderson Cancer Center Houston, Texas, United States, 77030-4009 Collapse << |
NCT00969046 | Colon Cancer | Phase 1 | Completed | - | Czech Republic ... more >> Novartis Investigative Site Hradec Králové, Czech Republic Novartis Investigative Site Prague, Czech Republic France Novartis Investigative Site Saint-Herblain Cedex, France Novartis Investigative Site Toulouse, France Spain Novartis Investigative Site Barcelona, Spain United Kingdom Novartis Investigative Site London, United Kingdom Collapse << |
NCT00450866 | - | - | Completed | - | - |
NCT00450866 | Breast Cancer ... more >> Metastatic Cancer Collapse << | Phase 2 | Completed | - | United States, Massachusetts ... more >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 United States, Michigan University of Michigan Comprehensive Cancer Center Ann Arbor, Michigan, United States, 48109 United States, New York Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10065 United States, Ohio Case Medical Center, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center Cleveland, Ohio, United States, 44106-5065 Cleveland Clinic Taussig Cancer Institute, Case Comprehensive Cancer Center Cleveland, Ohio, United States, 44195 Collapse << |
NCT00412789 | Tumors | Phase 1 | Completed | - | Japan ... more >> Novartis Investigative Site Tokyo, Japan Collapse << |
靶点 | Description | IC50 |
---|---|---|
Microtubule | EC0.01:1.8μM |
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