CAS No.: 107724-20-9
Eplerenone/依普利酮 Catalog No. CSN16692
Synonyms: Epoxymexrenone;SC-6110;SC-66110
Eplerenone is both a selective aldosterone blocker and a CYP3A4 substrate.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 细胞研究
- Cell Data
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT00232180 Heart Failure Phase 3 Completed - - NCT01805362 Chronic Kidney Disease Not Applicable Unknown February 2017 France ... more >> Department of Nephrology, Nice University Hospital Recruiting Nice, France, 06000 Contact: vincent Esnault, MD esnault.v@chu-nice.fr Principal Investigator: Vincent Esnault, MD Collapse << NCT02039492 Resistant Arterial Hypertensio... more >>n Collapse << Not Applicable Completed - Spain ... more >> Hospital General de l'Hospitalet Hospitalet, Barcelona, Spain, 08906 Hospital Universitari Mútua de Terrassa Terrassa, Barcelona, Spain, 08221 Hospital del Mar Barcelona, Spain, 08003 Collapse << - 更多
- 参考文献
- [1] Kobayashi N, Hara K, et al. Eplerenone shows renoprotective effect by reducing LOX-1-mediated adhesion molecule, PKCepsilon-MAPK-p90RSK, and Rho-kinase pathway. Hypertension. 2005 Apr;45(4):538-44.
- [2] Keidar S, Hayek T, et al. Effect of eplerenone, a selective aldosterone blocker, on blood pressure, serum and macrophage oxidative stress, and atherosclerosis in apolipoprotein E-deficient mice. J Cardiovasc Pharmacol. 2003 Jun;41(6):955-63.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 107724-20-9 | 储存条件 |
|
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| 分子式 | C24H30O6 | 运输 | 蓝冰 | |||||||
| 分子量 | 414.49 | 别名 | Epoxymexrenone;SC-6110;SC-66110;CGP-30083;Inspra;Selara;依普利酮 | |||||||
| 溶解度 |
|
动物实验配方 |
| Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
|---|
| 293 cells | - | Function assay | 16 h | Displacement of [3H]aldosterone from human mineralocorticoid receptor expressed in 293 cells after 16 hrs by scintillation counting, IC50=2.6 μM | 25187277 |
| COS1 cells | - | Function assay | 1 days | Antagonist activity at human MR transfected in human COS1 cells after 1 day by luciferase reporter gene assay, IC50=1.3 μM | 22074142 |
| Huh7 cells | - | Function assay | - | Antagonist activity at Gal4-tagged mineralocorticoid receptor expressed in human Huh7 cells by luciferase reporter gene assay, IC50=0.122 μM | 20672822 |
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
|---|
| NCT00232180 | Heart Failure | Phase 3 | Completed | - | - |
| NCT01805362 | Chronic Kidney Disease | Not Applicable | Unknown | February 2017 | France ... more >> Department of Nephrology, Nice University Hospital Recruiting Nice, France, 06000 Contact: vincent Esnault, MD esnault.v@chu-nice.fr Principal Investigator: Vincent Esnault, MD Collapse << |
| NCT02039492 | Resistant Arterial Hypertensio... more >>n Collapse << | Not Applicable | Completed | - | Spain ... more >> Hospital General de l'Hospitalet Hospitalet, Barcelona, Spain, 08906 Hospital Universitari Mútua de Terrassa Terrassa, Barcelona, Spain, 08221 Hospital del Mar Barcelona, Spain, 08003 Collapse << |
| NCT01655134 | Heart Failure | Not Applicable | Unknown | March 2015 | France ... more >> Brabois hospital Recruiting Nancy, France, 54500 Contact: Patrick Rossignol +33383157320 p.rossignol@chu-nancy.fr Contact: Faiez Zannad +33383157320 f.zannad@chu-nancy.fr Principal Investigator: Patrick Rossignol Sub-Investigator: Faiez Zannad Sub-Investigator: Daniela Dobre Sub-Investigator: Jean Marc BOIVIN Sub-Investigator: Nicolas GIRERD Sub-Investigator: Arnaud OLIVIER Collapse << |
| NCT03626506 | Hypertension | Not Applicable | Not yet recruiting | December 2020 | - |
| NCT02585843 | Heart Failure | Phase 2 Phase 3 | Unknown | September 2016 | United States, New York ... more >> Columbia University Medical Center Recruiting New York, New York, United States, 10032 Collapse << |
| NCT03174847 | - | - | Recruiting | January 30, 2020 | Singapore ... more >> Changi General Hospital Recruiting Singapore, Singapore, 529889 Contact: troy h puar, mrcp +65 68503967 troy_puar@cgh.com.sg Principal Investigator: Troy H Puar, MRCP Collapse << |
| NCT00223717 | Hypertension | Phase 1 | Completed | - | United States, Tennessee ... more >> Vanderbilt University Nashville, Tennessee, United States, 37232 Collapse << |
| NCT01882179 | ST-elevation Myocardial Infarc... more >>tion Collapse << | Phase 3 | Completed | - | United Kingdom ... more >> Cardiothoracic Center - Basildon and Thurrock University Hospitals Basildon, Essex, United Kingdom, SS16 5NL Leeds Genereal Infirmary Leeds, United Kingdom London Chest Hospital London, United Kingdom, E2 9JX Heart Hospital London London, United Kingdom, W1G 8PH Collapse << |
| NCT02345044 | Essential Hypertension | Phase 2 | Completed | - | Japan ... more >> Osaka, Japan, 530-0001 Collapse << |
| NCT02362308 | Primary Aldosteronism | Not Applicable | Recruiting | January 2020 | United States, Tennessee ... more >> Vanderbilt University Medical Center Recruiting Nashville, Tennessee, United States, 37232 Contact: Loretta Byrne, RN 615-322-2105 loretta.byrne@vanderbilt.edu Contact: Holly Waldrop 615-343-6161 holly.waldrop@vanderbilt.edu Principal Investigator: James M Luther, MD, MSCI Collapse << |
| NCT01373086 | Hypertension | Phase 2 | Terminated | - | United States, California ... more >> Advanced Clinical Research Institute-Phase I Anaheim, California, United States, 92801 United States, Florida Comprehensive Phase I Fort Myers, Florida, United States, 333901 Comprehensive Phase One®, Miramar, Florida, United States, 33025 Comprehensive NeuroScience St Petersburg, Florida, United States, 33716 United States, Georgia Clinical Research Atlanta Stockbridge, Georgia, United States, 30281 United States, Nebraska Clinical Research Advantage/ Prairie Fields Family Medicine, PC Fremont, Nebraska, United States, 68025 Internal Medicine Physicians Omaha, Nebraska, United States, 68130 ICON Developmental Solutions Omaha, Nebraska, United States, 68154 United States, Nevada Clinical Research Advantage/ Aloha Medical Las Vegas, Nevada, United States, 89183 United States, Texas ICON Development Solutions, San Antonio, Texas, United States, 78209 United States, Washington Comprehensive Clinical Development NW, Inc. Tacoma, Washington, United States, 98418 Collapse << |
| NCT03683069 | Hypertension ... more >>Genetics Hypertension Collapse << | Not Applicable | Not yet recruiting | August 31, 2022 | - |
| NCT00214825 | Diabetes Mellitus ... more >> Endothelial Dysfunction Albuminuria Collapse << | Not Applicable | Completed | - | United States, Massachusetts ... more >> Brigham and Women's Hospital Boston, Massachusetts, United States, 02115 Collapse << |
| NCT01427972 | Chronic Kidney Disease | Phase 2 | Completed | - | Bulgaria ... more >> For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Sofia, Bulgaria, 1612 South Africa For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Bloemfontein, South Africa, 9300 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Newton Park, South Africa, 6045 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Pretoria, South Africa, 0184 Collapse << |
| NCT02525796 | Primary Hyperparathyroidism | Phase 2 Phase 3 | Recruiting | December 2020 | United States, Massachusetts ... more >> Brigham and Women's Hospital Recruiting Boston, Massachusetts, United States, 02115 Contact: Molly Connors 617-732-5186 Collapse << |
| NCT01100203 | Chronic Kidney Disease | Phase 3 | Terminated(It was not possible... more >> within the time frame to recruit the planned no. of patients.) Collapse << | - | Denmark ... more >> Dept. Nephrology, Herlev Hospital Herlev, Denmark, DK-2730 Herlev Hospital Herlev, Denmark, DK-2730 Collapse << |
| NCT01541267 | Chronic Kidney Disease ... more >> Proteinuria Collapse << | Phase 4 | Completed | - | - |
| NCT01237899 | Chronic Kidney Disease | Phase 1 | Completed | - | Netherlands ... more >> For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Zuidlaren, Netherlands, 9471 GP Collapse << |
| NCT00817635 | Hypertension | Phase 2 | Completed | - | - |
| NCT01996449 | Hypertension | Not Applicable | Recruiting | December 2019 | United States, Texas ... more >> UT Southwestern Medical Center Recruiting Dallas, Texas, United States, 75390 Contact: Debbie Arbique, DNP 214-648-3188 debbie.arbique@utsouthwestern.edu Collapse << |
| NCT01394627 | Hypoglycemia | Not Applicable | Completed | - | United States, Massachusetts ... more >> Brigham and Women's Hospital Boston, Massachusetts, United States, 02115 Collapse << |
| NCT02532998 | Pharmacodynamics ... more >> Healthy Subjects Collapse << | Phase 1 | Completed | - | United Kingdom ... more >> Research Site Harrow, United Kingdom Collapse << |
| NCT02532998 | - | - | Completed | - | - |
| NCT00430924 | Kidney Failure, Chronic | Phase 4 | Completed | - | Denmark ... more >> Rigshospitalet, Blegdamsvej 9 Copenhagen, Denmark, DK-2100 Ø Herlev Hospital Herlev, Denmark, DK-2730 Collapse << |
| NCT01394627 | - | - | Completed | - | - |
| NCT02871648 | Healthy Volunteers | Phase 1 | Recruiting | July 2018 | United States, Massachusetts ... more >> Brigham and Women's Hospital Recruiting Boston, Massachusetts, United States, 02115 Principal Investigator: Jonathan S Williams, MD, MMSc Sub-Investigator: Gordon Williams, MD Sub-Investigator: Tina Gupta, MD Collapse << |
| NCT02809963 | Diabetes Type 2 | Phase 4 | Completed | - | Denmark ... more >> Herlev and Gentofte Hospital, Department of Endocrinology and Metabolism, Department of internal medicine, Herlev, Denmark, 2730 Collapse << |
| NCT03165240 | Diabetic Nephropathies | Phase 1 | Recruiting | December 30, 2019 | Denmark ... more >> Steno Diabetes Center Copenhagen Recruiting Gentofte, Denmark, DK-2820 Contact: Peter Rossing +45 38619705 Peter.Rossing@regionh.dk Kolding Sygehus Recruiting Kolding, Denmark, DK-6000 Contact: Ole Winther Rasmussen +45 4586523654 Ole.Winther.Rasmussen@rsyd.dk Bispebjerg Hospital Recruiting København NV, Denmark, 2400 Contact: Ole Svendsen +45 35312854 Ole.Lander.Svendsen@regionh.dk Rigshospitalet, København Recruiting København Ø, Denmark, 2100 Contact: Bo Feldt Rasmussen +45 35452135 bo.feldt-rasmussen@regionh.dk France HOP d'Angers Recruiting Angers, France, 49933 Contact: Séverine Dubois +33 (0)2 41 35 58 44 sedubois@chu-angers.fr HOP Nord Michallon Recruiting La Tronche, France, 38700 Contact: Philippe Zaoui +33 (0)4 76 76 55 23 pzaoui@chu-grenoble.fr HOP Bichat Recruiting Paris, France, 75018 Contact: Ronan Roussel +33 (0)1 40 25 73 01 ronan.roussel@gmail.com Hôpital la Milétrie - CHU Poitiers Recruiting Poitiers, France, 86021 Contact: Pierre-Jean Saulnier +33 (0)5 49 44 46 78 pierre-jean.saulnier@chu-poitiers.fr HOP Nord Laënnec Recruiting Saint-Herblain, France, 44800 Contact: Samy Hadjadj +33 (0)2 53 48 27 01 samy.hadjadj@gmail.com Germany Universitätsklinikum Carl Gustav Carus Dresden Recruiting Dresden, Germany, 01307 Contact: Andreas Birkenfeld +49 (351) 45813651 Andreas.Birkenfeld@uniklinikum-dresden.de InnoDiab Forschung GmbH Recruiting Essen, Germany, 45136 Contact: Thomas Schürholz +49 (201) 89942100 thomas.schuerholz@innodiab.de Inamed GmbH Recruiting Gauting, Germany, 82131 Contact: Bärbel Huber +49 (89) 893569533 b.huber@inamed-cro.com Medizinische Hochschule Hannover Recruiting Hannover, Germany, 30625 Contact: Christoph Schindler +49 (551) 53508300 schindler.christoph@mh-hannover.de Profil Institut für Stoffwechselforschung GmbH Recruiting Neuss, Germany, 41460 Contact: Grit Andersen 4921314018408 Grit.Andersen@profil.com Nephrologisches Zentrum Villingen-Schwenningen Recruiting Villingen-Schwenningen, Germany, 78052 Contact: Bernd Hohenstein +49 (721) 9985 0 hohenstein@nephrologie-vs.de Greece Univ. Gen. Hosp. of Ioannina Recruiting Ioannina, Greece, 45500 Contact: Moses Elisaf +302651007509 melisaf54@gmail.com Iatriko of Athens Group/ Iatriko of P. Faliro Recruiting P. Faliro, Greece, 17562 Contact: John Doupis +30 2109892300 john.doupis@joslin.harvard.edu Iatriko Psychikou Recruiting Psychiko, Greece, 11525 Contact: Gerasimos Karousos +302106974281 gkarousosmd@gmail.com University General Hospital of Thessaloniki AHEPA Recruiting Thessaloniki, Greece, 54636 Contact: Triantafyllos Didangelos 00302310994776 didang@med.auth.gr Slovakia Faculty hospital with clinics F.D. Roosevelta Recruiting Banska Bystrica, Slovakia, 97409 Contact: Eva Lackova +421 484 412 651 lackoe7@gmail.com Old Town Bratislava University Hosp, Recruiting Bratislava, Slovakia, 81369 Contact: Martin Caprnda +421257290449 martin.caprnda@gmail.com D & R s.r.o. Recruiting Kosice, Slovakia, 040 22 Contact: Jan Fedacko +421 55 7996395 janfedacko@hotmail.com Spain Hospital General Universitario Gregorio Marañón Recruiting Madrid, Spain, 28007 Contact: Marian Goicoechea +34915868319 marian.goicoechea@gmail.com Hospital Clínico de Valencia Recruiting Valencia, Spain, 46010 Contact: Josep Redón +34961973543 hcuvminterna@gmail.com Sweden CTC Sahlgrenska Universitetssjukhuset Recruiting Göteborg, Sweden, 413 45 Contact: Dan Curiac +4631 342 96 70 dan.curiac@vgregion.se Sjukhuset, Härnösand Recruiting Härnösand, Sweden, 87182 Contact: Staffan Salmonsson +46 611-20930 staffan.salmonsson@gmail.com CTC Clinical Trial Consultants AB Recruiting Uppsala, Sweden, 75237 Contact: Folke Sjöberg +46 70 1916652 folke.sjoberg@liu.se Universitetssjukhuset, Örebro Recruiting Örebro, Sweden, 701 85 Contact: Olof Hellberg 0046 19 602 10 00 olof.hellberg@regionorebrolan.se Collapse << |
| NCT03017703 | Endothelial Dysfunction ... more >> Insulin Resistance Collapse << | Not Applicable | Recruiting | November 2017 | Denmark ... more >> Cardiovascular and Renal Research Recruiting Odense, Denmark, 5000 Contact: Stefan P Mortensen, DMSc smortensen@health.sdu.dk Collapse << |
| NCT01146197 | Gitelman Syndrome | Phase 1 Phase 2 | Completed | - | France ... more >> Hopital Européen Georges Pompidou Paris, France, 75015 Collapse << |
| NCT00407784 | - | - | Unknown | - | Netherlands ... more >> Academical Medical Center Not yet recruiting Amsterdam, Netherlands VU medical Center Not yet recruiting Amsterdam, Netherlands IJsselland Hospital Not yet recruiting Capelle aan de IJssel, Netherlands Beatrix Hospital Not yet recruiting Gorinchem, Netherlands University Medical Center St. Radboud Not yet recruiting Nijmegen, Netherlands Erasmus Medical Center Recruiting Rotterdam, Netherlands Ikazia Hospital Recruiting Rotterdam, Netherlands MCRZ, lokation Zuider/Clara Not yet recruiting Rotterdam, Netherlands Oogziekenhuis Not yet recruiting Rotterdam, Netherlands Sint Franciscus Gasthuis Not yet recruiting Rotterdam, Netherlands Vlietland Hospital Not yet recruiting Schiedam, Netherlands Ruwaard van Putten Hospital Not yet recruiting Spijkenisse, Netherlands Twee Steden Ziekenhuis Not yet recruiting Waalwijk, Netherlands Collapse << |
| NCT01473108 | Pharmacology, Clinical | Phase 1 | Completed | - | Germany ... more >> Neuss, Nordrhein-Westfalen, Germany, 41460 Collapse << |
| NCT00608465 | - | - | Terminated(Lack of enrollment) | - | - |
| NCT01807221 | Heart Failure | Phase 2 | Completed | - | - |
| NCT01955694 | Heart Failure | Phase 2 | Completed | - | Japan ... more >> Seto, Aichi, Japan, 489-8642 Toyota, Aichi, Japan, 471-8513 Funabashi, Chiba, Japan, 273-8588 Kamogawa, Chiba, Japan, 296-0041 Kamogawa, Chiba, Japan, 296-8602 Matsuyama, Ehime, Japan, 790-0067 Chikushino, Fukuoka, Japan, 818-8516 Amagasaki, Hyogo, Japan, 660-8550 Kobe, Hyogo, Japan, 650-0047 Kobe, Hyogo, Japan, 654-0155 Higashiibaraki, Ibaraki, Japan, 311-3193 Hiratsuka, Kanagawa, Japan, 254-8502 Kawasaki, Kanagawa, Japan, 211-8533 Yokohama, Kanagawa, Japan, 245-8575 Uji, Kyoto, Japan, 611-0041 Sendai, Miyagi, Japan, 983-8520 Naha, Okinawa, Japan, 900-0005 Naha, Okinawa, Japan, 902-8511 Urasoe, Okinawa, Japan, 901-2132 Sayama, Saitama, Japan, 350-1305 Sayama, Saitama, Japan, 350-1323 Kusatsu, Shiga, Japan, 525-8585 Shinjuku-ku, Tokyo, Japan, 162-8655 Shinjuku-ku, Tokyo, Japan, 162-8666 Kofu, Yamanashi, Japan, 400-8506 Fukuoka, Japan, 810-0001 Kagoshima, Japan, 892-0853 Kyoto, Japan, 607-8062 Okayama, Japan, 700-8607 Osaka, Japan, 558-8558 Shizuoka, Japan, 420-8630 Collapse << |
| NCT01794091 | Diabetes Mellitus, Type II | Phase 1 | Unknown | - | United States, Massachusetts ... more >> Brigham and Women's Hospital Not yet recruiting Boston, Massachusetts, United States, 02114 Collapse << |
| NCT03342690 | - | - | Recruiting | February 28, 2020 | Japan ... more >> Pfizer Local Country Office Recruiting Tokyo, Japan Collapse << |
| NCT01521546 | Duchenne Muscular Dystrophy | Not Applicable | Completed | - | United States, California ... more >> Mattel Children's Hospital and David Geffen School of Medicine at UCLA Los Angeles, California, United States, 90095-1743 United States, Ohio Cincinnati Children's Hospital Medical Center Cincinnati, Ohio, United States The Ohio State University Medical Center Columbus, Ohio, United States, 43210 Collapse << |
| NCT01521546 | - | - | Completed | - | - |
| NCT00108251 | Congestive Heart Failure ... more >> Diastole Collapse << | Phase 4 | Completed | - | United States, Texas ... more >> Michael E DeBakey VA Medical Center Houston, Texas, United States, 77030 Collapse << |
| NCT00980031 | Myocardial Remodeling | Not Applicable | Terminated(Funding ended prior... more >> to study completion) Collapse << | - | United States, Nebraska ... more >> Creighton University Medical Center (including ambulatory centers) Omaha, Nebraska, United States, 68131 Collapse << |
| NCT00608465 | Metabolic Syndrome X | Phase 4 | Terminated(Lack of enrollment) | - | United States, Tennessee ... more >> Vanderbilt University Medical Center Nashville, Tennessee, United States, 37232 Collapse << |
| NCT02344199 | - | - | Completed | - | Greece ... more >> Gennimatas General State Hospital Athens, Attica, Greece 2nd Cardiology Department, University of Athens, Attikon Hospital, Haidari, Athens, Greece, 12462 Cardiology University Clinic Alexandroupolis, Greece Collapse << |
| NCT00749775 | - | - | Completed | - | - |
| NCT00427284 | - | - | Completed | - | Switzerland ... more >> University Hospital Zurich, Division of Cardiology Zurich, ZH, Switzerland, 8091 Collapse << |
| NCT02740179 | HIV | Not Applicable | Recruiting | - | United States, Massachusetts ... more >> Massachusetts General Hospital Recruiting Boston, Massachusetts, United States, 02114 Contact: Suman Srinivasa, MD, MS 617-724-9109 ssrinivasa@mgh.harvard.edu Contact: Steven K. Grinspoon, MD 6177249109 sgrinspoon@mgh.harvard.edu Collapse << |
| NCT00749775 | - | - | Completed | - | - |
| NCT00553722 | Hypertension ... more >>Dialysis Hyperaldosteronism Collapse << | Phase 4 | Unknown | November 2009 | Israel ... more >> Shaare Zedek Medical Center Not yet recruiting Jerusalem, Israel, 91031 Contact: Linda Shavit, MD 02 6555086 lshavit@szmc.org.il Principal Investigator: Linda Shavit, MD Collapse << |
| NCT01887119 | Abdominal Obesity Metabolic Sy... more >>ndrome Insulin Resistance Hypertension Collapse << | Phase 4 | Terminated(Failure to recruit ... more >>sufficient participants) Collapse << | - | Netherlands ... more >> Maastricht University Maastricht, Limburg, Netherlands, 6229 ER Collapse << |
| NCT02354352 | Duchenne Muscular Dystrophy | Phase 3 | Completed | - | United States, California ... more >> Mattel Children's Hospital and David Geffen School of Medicine at UCLA Los Angeles, California, United States, 90095-1743 United States, Colorado University of Colorado Aurora, Colorado, United States, 80045 United States, Kansas University of Kansas Medical Center Kansas City, Kansas, United States, 66103 United States, Ohio The Ohio State University Medical Center Columbus, Ohio, United States, 43210 United States, Tennessee Vanderbilt University Medical Center Nashville, Tennessee, United States, 37212 United States, Utah University of Utah Salt Lake City, Utah, United States, 84113 Collapse << |
| NCT00147563 | Hypertension | Phase 4 | Completed | - | Canada, Quebec ... more >> Pfizer Investigational Site Montreal, Quebec, Canada, H2W 1R7 Collapse << |
| NCT01275352 | Hypertension | Phase 4 | Withdrawn(Lack of funding) | - | United States, Missouri ... more >> Barnes Jewish Hospital St. Louis, Missouri, United States, 63108 United States, Pennsylvania Hospital of the University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 Collapse << |
| NCT00649311 | Hypertension | Phase 2 | Terminated(Poor enrollment; te... more >>rmination not due to safety reasons.) Collapse << | - | Taiwan ... more >> Pfizer Investigational Site Kaohsiung, Taiwan Pfizer Investigational Site Taipei, Taiwan Collapse << |
| NCT01893788 | Hypertensive Left Ventricular ... more >>Hypertrophy Collapse << | Phase 4 | Unknown | - | Japan ... more >> Department of Cardiology, Nagoya University Graduate School of Medicine Recruiting Nagoya, Aichi, Japan, 466-8550 Contact: Takanori Nagahiro, MD 81-52-744-2149 t-nagahiro@med.nagoya-u.ac.jp Contact: Toyoaki Murohara, MD, PhD 81-52-744-2149 murohara@med.nagoya-u.ac.jp Collapse << |
| NCT00138944 | Essential Hypertension | Phase 3 | Completed | - | Germany ... more >> CRC Medical Department IV Erlangen, Germany, 91054 Collapse << |
| NCT01319344 | Metabolic Syndrome ... more >> Endothelial Dysfunction Collapse << | Phase 3 | Completed | - | Germany ... more >> Clinical Research Unit, Department of Nephrology and Hypertension, University of Erlangen-Nurnberg Erlangen, Germany, 91054 Clinical Research Unit, Department of Nephrology and Hypertension, University of Erlangen-Nürnberg Nürnberg, Germany, 90471 Collapse << |
| NCT00703352 | Transposition of Great Vessels... more >> Atrial Switch Procedure Collapse << | Phase 4 | Completed | - | Spain ... more >> Hospital Universitari de la Vall d'Hebron Barcelona, Spain, 08035 Collapse << |
| NCT01440049 | - | - | Completed | - | - |
| NCT00865618 | Hypertension | Phase 1 | Completed | - | - |
| NCT01440049 | - | - | Completed | - | - |
| NCT00132093 | Myocardial Infarction | Phase 4 | Completed | - | United Kingdom ... more >> Western Infirmary Glasgow, Scotland, United Kingdom, G11 6NT Collapse << |
| NCT02607657 | Healthy Volunteers | Phase 1 | Withdrawn | - | - |
| NCT00082589 | Heart Failure, Congestive | Phase 4 | Completed | - | - |
| NCT02890173 | Essential Hypertension | Phase 3 | Completed | - | Japan ... more >> Sapporo, Hokkaido, Japan Collapse << |
| NCT00865176 | Hypertension | Phase 1 | Completed | - | - |
| NCT02153125 | Central Serous Chorioretinopat... more >>hy Collapse << | Phase 2 | Unknown | - | Israel ... more >> Tel Aviv Souraski Medical Center Recruiting Tel Aviv, Israel, 64239 Principal Investigator: Michaella Goldstein, MD Sub-Investigator: Roy Schwartz, MD Sub-Investigator: Michael Martinez, MD Sub-Investigator: Zohar Wilner, MD Sub-Investigator: Shiri Shulman, MD Sub-Investigator: Oded Ohana, MD Sub-Investigator: Shay Keren, MD Sub-Investigator: Dafna Goldenberg, MD Sub-Investigator: Meira Neuderfer, MD Sub-Investigator: Chanan Guzner-Gur, MD Sub-Investigator: Amir Nutman, MD Sub-Investigator: Anat Loewenstein, MD Collapse << |
| NCT00315016 | Diabetic Nephropathy | Phase 2 | Completed | - | Netherlands ... more >> Jeroen Bosch Hospital 's-Hertogenbosch, Noord Brabant, Netherlands University Medical Center Nijmegen St Radboud Nijmegen, Netherlands, 6525 GA Collapse << |
| NCT01832558 | CKD II-III | Phase 1 Phase 2 | Unknown | December 2016 | Austria ... more >> Medical University of Vienna Recruiting Vienna, Austria, 1090 Contact: Marcus Saemann, MD 01/40400/5593 marcus.saemann@meduniwien.ac.at Sub-Investigator: Johannes Kovarik, MD Collapse << |
| NCT00505336 | Diastolic Heart Failure | Not Applicable | Completed | - | Ireland ... more >> St Vincent's University Hospital Ballsbridge, Dublin, Ireland, 4 Collapse << |
| NCT00515021 | Metabolic Syndrome X | Phase 4 | Unknown | April 2010 | United States, Tennessee ... more >> Vanderbilt University Medical Center Nashville, Tennessee, United States, 37232-8802 Collapse << |
| NCT00647192 | Atrial Fibrillation | Phase 2 | Terminated(Inclusion rate too ... more >>low. Recruitment of further study centers too costly.) Collapse << | - | Germany ... more >> Universitätsklinikum des Saarlandes, Klinik für Innere Medizin III Homburg/Saar, Germany, 66421 Netherlands Rijksuniversiteit Groningen, Universitair Medisch Centrum Groningen, Netherlands, NL-9700 RB Collapse << |
| NCT00401856 | Cardiomyopathy | Phase 4 | Unknown | July 2010 | United Kingdom ... more >> Royal Brompton & Harefield NHS Trust Recruiting London, United Kingdom, SW3 6NP Contact: Sanjay Prasad, MD, MRCP Sub-Investigator: Dudley Pennell, MD FRCP FESC Sub-Investigator: Rory O'Hanlon, MRCPI Sub-Investigator: Martin Cowie, MD, MSc FRCP Collapse << |
| NCT01586442 | Heart Failure ... more >> Type 2 Diabetes Glucose Intolerance Collapse << | Phase 3 | Active, not recruiting | March 2018 | Canada, Quebec ... more >> Montreal Heart Institute Montreal, Quebec, Canada, H1T 1C8 Collapse << |
| NCT00147615 | Hypertension | Phase 3 | Completed | - | United States, California ... more >> Pfizer Investigational Site Los Angeles, California, United States, 90048 United States, Illinois Pfizer Investigational Site Park Ridge, Illinois, United States, 60068 United States, North Carolina Pfizer Investigational Site Durham, North Carolina, United States, 27710 United States, Ohio Pfizer Investigational Site Columbus, Ohio, United States, 43205-2696 Pfizer Investigational Site Columbus, Ohio, United States, 43205 United States, Texas Pfizer Investigational Site Houston, Texas, United States, 77030 Pfizer Investigational Site Katy, Texas, United States, 77094 India Pfizer Investigational Site Hyderabad, Andhra Pradesh, India, 500 033 Pfizer Investigational Site Bangalore, Karnataka, India, 560034 Pfizer Investigational Site Chennai, Tamil Nadu, India, 600 008 Pfizer Investigational Site Chennai, India, 600 031 Pfizer Investigational Site Mumbai, India, 400 012 Pfizer Investigational Site New Delhi, India, 110029 Russian Federation Pfizer Investigational Site Moscow, Russian Federation, 117869 Pfizer Investigational Site Moscow, Russian Federation, 119991 Pfizer Investigational Site Moscow, Russian Federation, 127412 Pfizer Investigational Site Smolensk, Russian Federation, 214019 Pfizer Investigational Site St. Petersburg, Russian Federation, 194100 Pfizer Investigational Site St. Petersburg, Russian Federation, 194291 Pfizer Investigational Site St. Petersburg, Russian Federation, 196191 Pfizer Investigational Site St. Petersburg, Russian Federation Collapse << |
| NCT00758524 | Essential Hypertension | Phase 2 | Completed | - | United States, New Jersey ... more >> Novartis Pharmaceuticals East Hanover, New Jersey, United States Collapse << |
| NCT01650012 | Hemodialysis ... more >>End Stage Renal Disease Collapse << | Not Applicable | Completed | - | Canada, Alberta ... more >> Calgary, Alberta, Canada Canada, Manitoba Winnipeg, Manitoba, Canada Canada, Ontario St. Joseph's Healthcare Hamilton, Ontario, Canada London, Ontario, Canada St. Michael's Hospital Toronto, Ontario, Canada Collapse << |
| NCT01801228 | Ascites Cirrh... more >>osis Collapse << | Phase 2 | Withdrawn(difficulties to incl... more >>ude patients) Collapse << | - | Sweden ... more >> University Hospital of Skane Lund, Skane, Sweden, 221 85 Collapse << |
| NCT00147589 | Hypertension | Phase 3 | Completed | - | - |
| NCT00293150 | Diastolic Heart Failure | Phase 4 | Terminated(Lack of eligible pa... more >>tients) Collapse << | - | United States, Ohio ... more >> The Cleveland Clinic Cleveland, Ohio, United States, 44195 Collapse << |
| NCT00187889 | Ischemic Heart Disease | Phase 4 | Completed | - | United States, Florida ... more >> University of Florida Gainesville, Florida, United States, 32610 Collapse << |
| NCT00187889 | - | - | Completed | - | - |
| NCT00825188 | Obesity Hyper... more >>tension Collapse << | Not Applicable | Terminated(funding to complete... more >> was inadequate) Collapse << | - | United States, Mississippi ... more >> The University of Mississippi Clinical Research Program Jackson, Mississippi, United States, 39216 Collapse << |
| NCT02462499 | Chronic Central Serous Chorior... more >>etinopathy Collapse << | Phase 4 | Completed | - | Hungary ... more >> Semmelweis University, Department of Ophthalmology Budapest, Hungary, 1085 Collapse << |
| NCT01405456 | - | - | Completed | - | - |
| NCT01405456 | HIV | Not Applicable | Completed | - | United States, Massachusetts ... more >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Collapse << |
| NCT01302236 | Hypertension ... more >>Chronic Kidney Disease. Collapse << | Phase 4 | Withdrawn(We could not find pa... more >>tients who agreed to enrolled this clinical study.) Collapse << | - | - |
| NCT03476616 | Hypertension ... more >>Obesity Collapse << | Phase 4 | Not yet recruiting | September 1, 2020 | Greece ... more >> Hypertension Unit, First Cardiology Clinic, Hippocration General Hospital, University of Athens, Athens, Greece Not yet recruiting Athens, Greece, 11527 Contact: Konstantinos P Tsioufis, Ass. Prof. 6932586087 ext +30 ktsioufis@hippocratio.gr Contact: Panayiotis P Iliakis, MD 6937489286 ext +30 panayiotisiliakis@gmail.com Principal Investigator: Konstantinos P Tsioufis, Ass. Prof. Sub-Investigator: Kyriakos S Dimitriadis, MD, PhD Sub-Investigator: Panayiotis P Iliakis, MD Collapse << |
| NCT01115855 | Heart Failure | Phase 3 | Completed | - | - |
| NCT00232180 | - | - | Completed | - | - |
| NCT02215330 | Central Serous Chorioretinopat... more >>hy Collapse << | Phase 2 Phase 3 | Unknown | September 2017 | Austria ... more >> Oliver Findl Not yet recruiting Vienna, Austria, 1140 Contact: Oliver Findl, MD, Prof, MBA 0043191021 ext 57568 ofindl@googlemail.com Principal Investigator: Oliver Findl, MD, Prof, MBA Collapse << |
| NCT01857856 | Phospholamban R14del Mutation-... more >>related Cardiomyopathy Collapse << | Phase 3 | Active, not recruiting | July 2021 | Netherlands ... more >> Antonius ziekenhuis Sneek Sneek, Friesland, Netherlands, 8600BA AMC Amsterdam, North-Holland, Netherlands, 1105 AZ UMCG Groningen, Netherlands, 9700RB UMCU Utrecht, Netherlands, 3584 CX Collapse << |
| NCT02629094 | Cardiac Steatosis ... more >> Hepatic Steatosis Collapse << | Phase 2 | Terminated | - | United States, Maryland ... more >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Collapse << |
| NCT01708798 | Breast Cancer | Phase 2 Phase 3 | Terminated(Futility) | - | Canada, British Columbia ... more >> British Columbia Cancer Agency, Vancouver Centre Vancouver, British Columbia, Canada, V5Z 4E6 Collapse << |
| NCT01176968 | Myocardial Infarction | Phase 4 | Completed | - | - |
| NCT01115855 | - | - | Completed | - | - |
| NCT03418649 | Degenerative Intervertebral Di... more >>scs Sciatic Radiculopathy Low Back Pain Collapse << | Phase 4 | Recruiting | June 2019 | United States, Ohio ... more >> UC Health Pain Medicine Center in Midtown Recruiting Cincinnati, Ohio, United States, 45213 UC Health Pain Medicine Center in West Chester Not yet recruiting West Chester, Ohio, United States, 45069 UC Health Pain Medicine Center West Chester Recruiting West Chester, Ohio, United States, 45069 Collapse << |
| NCT00990223 | Healthy Volunteers | Phase 1 | Completed | - | United States, Florida ... more >> Pfizer Investigational Site Miami, Florida, United States, 33143 Pfizer Investigational Site South Miami, Florida, United States, 33143 Collapse << |
| NCT02629094 | - | - | Terminated | - | - |
| NCT01786551 | Systemic Proinflammatory State | Not Applicable | Completed | - | United States, Massachusetts ... more >> Brigham and Women's Hospital Boston, Massachusetts, United States, 02115 Collapse << |
| NCT01834768 | Chronic Kidney Insufficiency ... more >> Kidney Transplantation Collapse << | Phase 2 | Unknown | December 2013 | France ... more >> Centre Hospitalier Universitaire de Reims Recruiting Reims, France, 51092 Contact: Philippe RIEU, PhD, MD prieu@chu-reims.fr Principal Investigator: Philippe RIEU, PhD, MD Collapse << |
| NCT01176968 | - | - | Completed | - | - |
| NCT01786551 | - | - | Completed | - | - |
| NCT02490904 | End-stage Renal Disease | Phase 3 | Recruiting | July 2030 | France ... more >> CHRU Besançon Recruiting Besancon, France Contact: Didier DUCLOUX Principal Investigator: Didier DUCLOUX CHU Brest Recruiting Brest, France Contact: Yannick LE MEUR, Prof Principal Investigator: Yannick LE MEUR, Prof CHU Dijon- Hôpital Bocage Central Recruiting Dijon, France Contact: Christiane MOUSSON Principal Investigator: Christiane MOUSSON CHRU de Nancy Recruiting Nancy, France Contact: Sophie GIRERD Principal Investigator: Sophie GIRERD CHU Reims-Hôpital Maison Blanche Recruiting Reims, France Contact: Philippe RIEU Principal Investigator: Philippe RIEU CHU Saint Etienne Not yet recruiting Saint-Étienne, France Contact: Christophe MARIAT, Prof Principal Investigator: Christophe MARIAT, Prof NHC -CHRU Strasbourg Recruiting Strasbourg, France Contact: Bruno MOULIN Principal Investigator: Bruno MOULIN Collapse << |
| NCT01971593 | Tetralogy of Fallot ... more >> Transposition of the Great Vessels With an Arterial Switch Single Ventricle With a Fontan Palliation Collapse << | Phase 4 | Terminated(Investigator left i... more >>nstitution) Collapse << | - | United States, Missouri ... more >> Washington University School of Medicine Saint Louis, Missouri, United States, 63110 Collapse << |
| NCT02345590 | Aortic Aneurysm, Abdominal | Phase 4 | Recruiting | December 2019 | Australia, Victoria ... more >> Baker IDI Recruiting Melbourne, Victoria, Australia, 3000 Contact: Leah Isles, MBBS 61 3 90763263 l.iles@alfred.org.au Contact: Andrew Taylor, MBBS 61 3 90763263 a.taylor@alfred.org.au Heart Centre, Alfred Health Recruiting Melbourne, Victoria, Australia, 3004 Contact: Leah Isles, MBBS 61 3 90763263 l.iles@alfred.org.au Contact: Andrew Taylor, MBBS 61 3 90763263 a.taylor@alfred.org.au Collapse << |
| NCT01971593 | - | - | Terminated(Investigator left i... more >>nstitution) Collapse << | - | - |
| NCT02957435 | Pharmacokinetics ... more >> Healthy Subjects Fasting Collapse << | Phase 1 | Withdrawn(Study has been cance... more >>lled and it has not been initiated.) Collapse << | December 2017 | Brazil ... more >> CAEP - Centro Avançado de Estudos e Pesquisas Ltda. Campinas, São Paulo, Brazil, 13087567 Collapse << |
| NCT01990677 | - | - | Completed | - | - |
| NCT03079141 | Chronic Central Serous Chorior... more >>etinopathy Collapse << | Phase 4 | Recruiting | February 2021 | Netherlands ... more >> Academic Medical Center Recruiting Amsterdam, Netherlands Contact: Reinier O Schlingemann, MD, PhD Contact: Monique Wezel Leiden University Medical Center Recruiting Leiden, Netherlands Contact: Elon H van Dijk, MD +31715299431 ehcvandijk@lumc.nl Contact: Thomas J van Rijssen, MD t.j.van_rijssen@lumc.nl Radboud University Medical Center Recruiting Nijmegen, Netherlands Contact: Carel B Hoyng, MD, PhD Contact: Asha Kalisingh Collapse << |
| NCT01822561 | Central Serous Chorioretinopat... more >>hy Collapse << | Phase 2 | Completed | - | United States, Massachusetts ... more >> New England Eye Center / Tufts Medical Center Boston, Massachusetts, United States, 02111 Collapse << |
| NCT02118753 | Ischemia-reperfusion Injury | Not Applicable | Completed | - | Netherlands ... more >> Radboud University Medical Centre Nijmegen, Gelderland, Netherlands, 6500HB Collapse << |
| NCT01990677 | Central Serous Chorioretinopat... more >>hy Collapse << | Not Applicable | Completed | - | United States, New Jersey ... more >> Mid Atlantic Retina Cherry Hill, New Jersey, United States, 08002 Mid Atlantic Retina Marlton, New Jersey, United States, 08053 Mid Atlantic Retina Mays Landing, New Jersey, United States, 08330 United States, Pennsylvania Mid Atlantic Retina Bala-Cynwyd, Pennsylvania, United States, 19004 Mid Atlantic Retina Bethlehem, Pennsylvania, United States, 18020 Mid Atlantic Retina Huntingdon Valley, Pennsylvania, United States, 19006 Mid Atlantic Retina Lansdale, Pennsylvania, United States, 19446 Mid Atlantic Retina New Wilmington, Pennsylvania, United States, 19803 Mid Atlantic Retina Newtown Square, Pennsylvania, United States, 19073 Mid Atlantic Retina Plymouth Meeting, Pennsylvania, United States, 19462 Collapse << |
| NCT01837108 | Pharmacodynamics | Phase 4 | Completed | - | Netherlands ... more >> Radboud University Medical Centre Nijmegen, Gelderland, Netherlands, 6525EZ Collapse << |
| NCT03186742 | Hypertension,Essential ... more >> Obstructive Sleep Apnea Left Ventricular Hypertrophy Collapse << | Phase 4 | Completed | - | - |
| NCT01822561 | - | - | Completed | - | - |
