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CAS No.: 77671-31-9
Synonyms: MDL 17043;Perfan;Fenoximone
Enoximone is an inotropic vasodilating agent and a selective and orally active phosphodiesterase III (PDE3) inhibitor with an IC50 of 5.9 μM. Enoximone induces vasodilatation and increases intracellular levels of cAMP by inhibiting cGMP-inhibited PDE. Enoximone also exhibits PDE4 inhibitory effect with an IC50 of 21.1 μM for myocardial PDE4A. Enoximone has the potential for congestive heart failure research and has bronchodilatory, antiasthma and anti-inflammatory effects.
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生物活性
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
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NCT03772990 | Cardiac Surgery ... more >> Cardiopulmonary Bypass Collapse << | Phase 4 | Not yet recruiting | March 30, 2022 | - |
NCT01864252 | Myocardial Reperfusion Injury | Phase 3 | Unknown | February 2016 | United Kingdom ... more >> The Heart Hospital, UCL Hospitals NHS Trust Recruiting London, United Kingdom, NW1 2PG Contact: Ashraf Hamarneh, MBchB,MRCP 02034479781 a.hamarneh@ucl.ac.uk Principal Investigator: Derek M Yellon, PhD DSc FACC Principal Investigator: Derek J Hausenloy, MD PhD FRCP Sub-Investigator: Ashraf Hamarneh, MBchB MRCP Sub-Investigator: Shyam Kolvekar, MS MCh FRCS Sub-Investigator: Roger Cordery, BSc FRCA Sub-Investigator: Vivek Sivaraman, MRCP MD FRCA Collapse << |
NCT00484133 | Severe Sepsis ... more >> Microcirculation Collapse << | Phase 4 | Unknown | - | Netherlands ... more >> Onze Lieve Vrouwe Gasthuis, intensive care Recruiting Amsterdam, Netherlands, 1090 HM Contact: Rutger v Raalte, MD 0031205993007 R.vanRaalte@olvg.nl Principal Investigator: Rutger v Raalte, MD Collapse << |
实验方案
技术信息
CAS号 | 77671-31-9 | 储存条件 |
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分子式 | C12H12N2O2S | 运输 | 蓝冰 | |||
分子量 | 248.30 | 别名 | MDL 17043;Perfan;Fenoximone;Enoximonum [Latin];MDL 19438;MDL-17,043;MDL-19,438;烯氟酮 | |||
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