生物活性

• 描述Endoxifen hydrochloride, the active metabolite of Tamoxifen, is a potent antiestrogen that targets estrogen receptor.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT02311933	Estrogen Receptor Positive ... more >> HER2/Neu Negative Recurrent Breast Carcinoma Stage III Breast Cancer AJCC v7 Stage IIIA Breast Cancer AJCC v7 Stage IIIB Breast Cancer AJCC v7 Stage IIIC Breast Cancer AJCC v7 Stage IV Breast Cancer AJCC v6 and v7 Collapse <<	Phase 2	Active, not recruiting	-	-
  NCT03317405	BRCA1 Gene Mutation ... more >> BRCA2 Gene Mutation Ductal Breast Carcinoma In Situ Lobular Breast Carcinoma In Situ Prophylactic Mastectomy Patient Stage 0 Breast Cancer AJCC v6 and v7 Stage I Breast Cancer AJCC v7 Stage IA Breast Cancer AJCC v7 Stage IB Breast Cancer AJCC v7 Stage II Breast Cancer AJCC v6 and v7 Stage IIA Breast Cancer AJCC v6 and v7 Stage IIB Breast Cancer AJCC v6 and v7 Stage III Breast Cancer AJCC v7 Stage IIIA Breast Cancer AJCC v7 Stage IIIB Breast Cancer AJCC v7 Stage IIIC Breast Cancer AJCC v7 Collapse <<	Phase 1	Recruiting	September 1, 2019	United States, California ... more >> Cedars Sinai Medical Center Recruiting Los Angeles, California, United States, 90048 Contact: Scott R. Karlan    310-423-9331    KarlanS@cshs.org    Principal Investigator: Scott R. Karlan          United States, Illinois Northwestern University Recruiting Chicago, Illinois, United States, 60611 Contact: Seema A. Khan    312-472-0585    skhan@nm.org    Principal Investigator: Seema A. Khan          United States, New York Memorial Sloan Kettering Cancer Center Not yet recruiting New York, New York, United States, 10065 Contact: Melissa L. Pilewskie    646-888-4590    pilewskm@mskcc.org    Principal Investigator: Melissa L. Pilewskie Collapse <<
  NCT01327781	Estrogen Receptor Positive ... more >> HER2/Neu Positive Hot Flashes Recurrent Breast Carcinoma Stage IIIC Breast Cancer AJCC v7 Stage IV Breast Cancer AJCC v6 and v7 Collapse <<	Phase 1	Active, not recruiting	-	United States, Arizona ... more >> Mayo Clinic in Arizona Scottsdale, Arizona, United States, 85259 United States, Florida Mayo Clinic in Florida Jacksonville, Florida, United States, 32224-9980 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 Collapse <<

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• 参考文献

• [1] Benedykcinska A, Ferreira A, et al. Generation of brain tumours in mice by Cre-mediated recombination of neural progenitors in situ with the tamoxifen metabolite endoxifen. Dis Model Mech. 2016 Feb;9(2):211-20.

  [2] Wu X, Hawse JR, et al. The tamoxifen metabolite, endoxifen, is a potent antiestrogen that targets estrogen receptor alpha for degradation in breast cancer cells. Cancer Res. 2009 Mar 1;69(5):1722-7.