|6-氯-7-甲氧基-2-甲基-3-(4-(4-(三氟甲氧基)苯氧基)苯基)喹啉-4(1H)-酮|CsnPharm

CAS No.: 1354745-52-0

ELQ-300 Catalog No. CSN27654

Synonyms: ELQ-300

ELQ-300, a bioavailable antimalarial agent, is a potent inhibitor of the reductive (Qi) site of the cytochrome bc1 complex (cyt bc1).

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Complex III of the mitochondrial electron transport chain, also known as the cytochrome bc₁ complex (cyt bc₁), is a validated target for multistage antimalarial therapy. ELQ-300, a potent and orally bioavailable antimalarial agent, acts as an inhibitor of the reductive (Q_i) site of cyt bc₁. ELQ-300 sensitized P. falciparum Dd2, Tm90-C2B, and D1 strains with IC₅₀s of 6.6, 4.6 and 160 nM, respectively. Compared to the 6-halogen compounds ELQ-314, ELQ-296, and ELQ-339, ELQ-300 demonstrated both increased potency and more pronounced D1 cross-resistance, which correlated with halogen size^[1].
参考文献

[1] Stickles AM, et al. Subtle changes in endochin-like quinolone structure alter the site of inhibition within the cytochrome bc1 complex of Plasmodium falciparum. Antimicrob Agents Chemother. 2015 Apr;59(4):1977-82

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.1015 mL
- 10.5076 mL
- 21.0153 mL
- 5 mM
- 0.4203 mL
- 2.1015 mL
- 4.2031 mL
- 10 mM
- 0.2102 mL
- 1.0508 mL
- 2.1015 mL

技术信息

CAS号

1354745-52-0

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C24H17ClF3NO4

运输

蓝冰

分子量

475.84

别名

ELQ-300

溶解度

DMSO	15.0 mg/mL (31.5 mM) warming
Water	Insoluble

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

ELQ-300 Catalog No. CSN27654

靶点选择性

请登录您的专属账户

确认信息