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CAS No.: 519-23-3

Ellipticine Catalog No. CSN12399

Synonyms: NSC 71795;CCG-36483;DB-052047

Ellipticine is a potent antineoplastic agent exhibiting multiple mechanisms of action, IC50 of 1.25±0.13, 0.67±0.06, 1.25±0.13, 0.67±0.06, 0.27±0.02, 0.44±0.03, 0.49±0.04, and 1.48±0.62 μM for Breast adenocarcinoma MCF-7, Leukemia HL-60, Breast adenocarcinoma MCF-7, Leukemia HL-60, Neuroblastoma IMR-32, Neuroblastoma UKF-NB-3, Neuroblastoma UKF-NB-4, and Glioblastoma U87MG cell, respectively.

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生物活性

描述Ellipticine is cell-permeable antitumor alkaloid that acts as an inhibitor of topoisomerase II and acts as an intercalative agent that stimulates topoisomerase II-mediated DNA breakdown^[3]. Ellipticine induced a significant decrease in MyLa2000 and SeAx cell viability at the concentration of 5-10μM (dose-dependently) and Hut-78 cells at the concentration of 20μM^[4]. Ellipticine has been shown to inhibit the proliferation of human breast adenocarcinoma MCF-7 cells, leukemia HL-60 and CCRF-CEM cells, neuroblastoma IMR-32, UKF-NB-3, and UKF-NB-4 cells, and U87MG glioblastoma cells with IC50 values ranging from 0.27-4.7 µM^[5].
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实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.0600 mL
- 20.2999 mL
- 40.5998 mL
- 5 mM
- 0.8120 mL
- 4.0600 mL
- 8.1200 mL
- 10 mM
- 0.4060 mL
- 2.0300 mL
- 4.0600 mL

技术信息

CAS号	519-23-3	储存条件	粉末 Keep in dark place,Sealed in dry,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C17H14N2	运输	蓝冰
分子量	246.31	别名	NSC 71795;CCG-36483;DB-052047;K00071;LP00531;LS-133282;TCMDC-125546;VZ29809;Elliptecine;Elliptisine;玫瑰树碱

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