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CAS No.: 27220-47-9

Econazole/益康唑 Catalog No. CSN12439

Synonyms: (±)-Econazol;CCRIS-9032;益康唑

Econazole is an imidazole-derived and broad-spectrum antimycotic agent with fungistatic properties, working by inhibiting biosynthesis of ergosterol, thereby damaging the fungal cell wall membrane and altering its permeability.

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技术信息

生物活性

描述Econazole is an antifungal agent and a new PI3K (phosphatidylinositol-3-kinase) inhibitor and a potential drug that can be used in lung cancer treatment alone or in combination with cisplatin. Econazole significantly suppressed A549 tumor growth in nude mice^[3]. Guinea-pigs infected with T. mentagrophytes, M. canis or C. albicans and treated topically or orally with econazole, were cured. In each of these tests the activity of econazole was compared with that of different reference drugs. Vaginal candidiasis in rats was cured after oral administration of econazole. Toxicity and teratogenicity studies in different laboratory animals indicate that econazole is well tolerated^[4]. The econazole-bound TRPV5 (transient receptor potential vanilloid 5) structure adopts a closed conformation with a distinct lower gate that occludes Ca²⁺ permeation through the channel^[5]. Moreover, econazole nitrate loaded transethosomes are effective to deliver econazole nitrate transdermally in a controlled fashion for effective elimination of cutaneous candidiasis^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00385502	Onychomycosis	Phase 2	Unknown	June 2008	United States, Arizona ... more >> Tucson, Arizona, United States, 85741 United States, New York New York, New York, United States, 10032 United States, Oregon Portland, Oregon, United States, 97210 Collapse <<
NCT03129321	Tinea Pedis	Phase 3	Completed	-	-
NCT03129321	-	-	Completed	-	-

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.6200 mL
- 13.0999 mL
- 26.1997 mL
- 5 mM
- 0.5240 mL
- 2.6200 mL
- 5.2399 mL
- 10 mM
- 0.2620 mL
- 1.3100 mL
- 2.6200 mL

技术信息

CAS号

27220-47-9

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C18H15Cl3N2O

运输

蓝冰

分子量

381.68

别名

(±)-Econazol;CCRIS-9032;益康唑

溶解度

DMSO	76.0 mg/mL (199.1 mM)

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT00385502	Onychomycosis	Phase 2	Unknown	June 2008	United States, Arizona ... more >> Tucson, Arizona, United States, 85741 United States, New York New York, New York, United States, 10032 United States, Oregon Portland, Oregon, United States, 97210 Collapse <<
NCT03129321	Tinea Pedis	Phase 3	Completed	-	-
NCT03129321	-	-	Completed	-	-
NCT01696799	Interdigital Tinea Pedis	Phase 2	Completed	-	United States, California ... more >> Therapeutics Inc. San Diego, California, United States, 92123 Collapse <<
NCT01353976	Tinea Pedis A... more >>thlete's Foot Collapse <<	Phase 3	Completed	-	United States, Florida ... more >> Francisco Flores, MD Miramar, Florida, United States, 33027 United States, Michigan Daniel M. Stewart, DO Clinton Township, Michigan, United States, 48038 United States, Nevada Cyaandi Dove, DPM Las Vegas, Nevada, United States, 89119 United States, Ohio Robert S. Haber, MD South Euclid, Ohio, United States, 44118 United States, South Carolina Cynthia Strout, MD Mt. Pleasant, South Carolina, United States, 29464 United States, Tennessee Michael H. Gold, MD Nashville, Tennessee, United States, 37215 United States, Texas Jeffrey Adelglass, MD Plano, Texas, United States, 75234 Collapse <<
NCT01353976	-	-	Completed	-	-
NCT00768599	-	-	Completed	-	-
NCT00915629	Vaginal Candidiasis	Not Applicable	Terminated	-	France ... more >> Pileje 37 Quai de Grenelle, Paris, France, 75015 Collapse <<
NCT02713893	Healthy	Phase 1	Completed	-	Switzerland ... more >> CROSS Research S.A., Phase I Unit Arzo, Switzerland, CH-6864 Collapse <<
NCT01358240	Tinea Pedis A... more >>thlete's Foot Collapse <<	Phase 3	Completed	-	United States, California ... more >> Sunil S. Dhawan, MD Fremont, California, United States, 94538 United States, Delaware Guy F. Webster, MD, PhD Hockessin, Delaware, United States, 19707 United States, Florida Marta I. Rendon, MD Boca Raton, Florida, United States, 33486 Jonathan Kantor, MD Jacksonville, Florida, United States, 32204 United States, Minnesota Steven E. Kempers, MD Fridley, Minnesota, United States, 55432 United States, Nebraska Joel Schlessinger, MD Omaha, Nebraska, United States, 68144 United States, Oregon Phoebe Rich, MD Portland, Oregon, United States, 97210 United States, Tennessee Edward J. Primka III, MD Knoxville, Tennessee, United States, 37917 United States, Texas Michael T. Jarratt, MD Austin, Texas, United States, 78759 William Abramovits, MD Dallas, Texas, United States, 75230 United States, Virginia David M. Pariser, MD, FAAD, FACP Norfolk, Virginia, United States, 23507 United States, Wisconsin Harry H. Sharata, MD, PhD Madison, Wisconsin, United States, 53719 Collapse <<
NCT02720783	Healthy Women	Phase 1	Completed	-	Switzerland ... more >> CROSS Research S.A., Phase I Unit Arzo, Switzerland, CH-6864 Collapse <<
NCT00768599	Tinea Pedis A... more >>thlete's Foot Collapse <<	Phase 2	Completed	-	United States, California ... more >> Stacy Smith, MD San Diego, California, United States, 92123 United States, Michigan Daniel Stewart, DO Clinton Township, Michigan, United States, 48038 United States, Minnesota Steven Kempers, MD Fridley, Minnesota, United States, 55432 United States, Tennessee Michael Gold, MD Nashville, Tennessee, United States, 37215 United States, Texas Michael Jarratt, MD Austin, Texas, United States, 78759 United States, Utah Leonard Swinyer, MD Salt Lake City, Utah, United States, 84124 Collapse <<

Econazole/益康唑 Catalog No. CSN12439

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