|4-(4-(二苯甲氧基)哌啶-1-基)-1-(4-(叔丁基)苯基)丁酮|CsnPharm

CAS No.: 90729-43-4

Ebastine/依巴斯汀 Catalog No. CSN10883

Synonyms: LAS-W 090;RP64305;Brand name: Evastin

Ebastine is a selective H1-histamine receptor antagonist.

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生物活性

实验方案

技术信息

生物活性

描述Ebastine is a second-generation histamine H1 receptor antagonist that is used to attenuate allergic inflammation. Ebastine was shown to significantly increase the proliferation of HFDPC (human follicle dermal papilla cells)^[3]. Ebastine is a well-established second generation oral H1-antihistamine that is administered once daily at a dose of 10 - 20 mg and is available both as a standard tablet and as a fast-dissolving tablet that disintegrates in the mouth. Ebastine has been shown to relieve symptoms in patients with allergic rhinitis or urticaria in multiple clinical trials. Ebastine is generally well tolerated at recommended doses^[4]. Pooled data from clinical efficacy trials of ebastine 1 - 30 mg/day administered for 2 - 3 weeks showed no clinically relevant cardiac effects as assessed by serial electrocardiographs and Holter monitoring^[5]. Ebastine 10 mg daily is a well tolerated and effective treatment for allergic rhinitis and chronic idiopathic urticaria^[6]. Ebastine 20 mg/day is indicated in patients with moderate and severe allergic symptoms, it has no relevant effects on the psychomotor performance^[7].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01144832	Irritable Bowel Syndrome	Phase 4	Completed	-	Belgium ... more >> University hospitals Leuven Leuven, Vlaams-Brabant, Belgium, 3000 Collapse <<
NCT01940393	Urticaria	Phase 4	Completed	-	Colombia ... more >> Medellin Medellin, Antioquia, Colombia Collapse <<
NCT02065440	Cough	Not Applicable	Unknown	-	Korea, Republic of ... more >> Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul Metropolitan Government, Seoul National University Boramae Medical Center Seoul, Dongjak-Gu, Korea, Republic of, 156-707 Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.1292 mL
- 10.6461 mL
- 21.2921 mL
- 5 mM
- 0.4258 mL
- 2.1292 mL
- 4.2584 mL
- 10 mM
- 0.2129 mL
- 1.0646 mL
- 2.1292 mL

技术信息

CAS号

90729-43-4

储存条件

粉末: Keep in dark place,Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C32H39NO2

运输

蓝冰

分子量

469.66

别名

LAS-W 090;RP64305;Brand name: Evastin;Kestine;Ebastel;Aleva;Ebatrol;Bactil;Busidril;Evastel;Kestin;依巴斯汀

溶解度

DMSO	300.0 mg/mL (638.8 mM) warming
Water	insoluble

动物实验配方

IP	2% DMSO+2% Tween80+30% PEG300+water	6 mg/mL	clear
PO	0.5% CMC-Na	38 mg/mL	suspension

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT01144832	Irritable Bowel Syndrome	Phase 4	Completed	-	Belgium ... more >> University hospitals Leuven Leuven, Vlaams-Brabant, Belgium, 3000 Collapse <<
NCT01940393	Urticaria	Phase 4	Completed	-	Colombia ... more >> Medellin Medellin, Antioquia, Colombia Collapse <<
NCT02065440	Cough	Not Applicable	Unknown	-	Korea, Republic of ... more >> Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul Metropolitan Government, Seoul National University Boramae Medical Center Seoul, Dongjak-Gu, Korea, Republic of, 156-707 Collapse <<
NCT01908465	Irritable Bowel Syndrome (IBS)	Phase 4	Recruiting	March 2018	Belgium ... more >> UZ Antwerpen Not yet recruiting Edegem, Antwerpen, Belgium, 2650 Contact: Tom Moreels, M.D. +32 3 821 33 24 tom.moreels@uza.be Sub-Investigator: Tom Moreels, M.D. ZOL (Ziekenhuis Oost-Limburg) Recruiting Genk, Limburg, Belgium, 3600 Contact: Philip Caenepeel, M.D. +32 8 32 65 13 philip.caenepeel@zol.be Sub-Investigator: Philip Caenepeel, M.D. UZ Gent Recruiting Gent, Oost-Vlaanderen, Belgium, 9000 Contact: Sabine Van de Moortele +32 9 332 68 54 Sabine.VandeMoortele@uzgent.be Contact: Muriël Fouquet +32 9 332 33 36 Muriel.Fouquet@uzgent.be Sub-Investigator: Danny De Looze, M.D. AZ Sint-Elizabeth Zottegem Recruiting Zottegem, Oost-Vlaanderen, Belgium, 9620 Contact: Inge Vanslembrouck, M.D. +32 93 64 83 41 inge.vanslembrouck@sezz.be Contact: Inge Vanslembrouck, M.D. +32 93 64 83 43 inge.vanslembrouck@sezz.be Sub-Investigator: Sebastien Kindt, M.D. UZ Leuven Recruiting Leuven, Vlaams-Brabant, Belgium, 3000 Contact: Lien Beullens, MSc 0032-16-341943 lien.beullens@kuleuven.be Contact: Dafne Balemans 0032-16-330158 dafne.balemans@med.kuleuven.be Principal Investigator: Guy Boeckxstaens, M.D. AZ Sint-Lucas Brugge Recruiting Brugge, West-Vlaanderen, Belgium, 8310 Contact: Hilde Nevens +32 50 36 57 11 hilde.nevens@stlucas.be Contact: Joris Arts, M.D. +32 50 36 51 55 jar@stlucas.be Sub-Investigator: Joris Arts, M.D. Netherlands Rijnstate Not yet recruiting Arnhem, Gelderland, Netherlands, 6800 Contact: B.G. Baten, M.D. 0031 88 005 6671 Contact: D. Hirsch, M.D. DHirsch@Rijnstate.nl Sub-Investigator: D. Hirsch, M.D. Medisch Spectrum Twente Not yet recruiting Enschede, Limburg, Netherlands, 7500 Contact: Anita Westerhof 0031(53)4877511 Contact: J. Kolkman, M.D. 0031 (53) 487 24 10 j.kolkman@mst.nll Sub-Investigator: J. Kolkman, M.D. AZ Maastricht Not yet recruiting Maastricht, Limburg, Netherlands, 6202 Contact: Samefko Ludidi Contact: A. Masclee, M.D. a.masclee@mumc.nl Sub-Investigator: A. Masclee Sint Lucas Andreas Ziekenhuis Not yet recruiting Amsterdam, Noord-Holland, Netherlands, 1061 Contact: Sjoerd Kuiken, M.D. s.kuiken@slaz.nl Sub-Investigator: Sjoerd Kuiken, M.D. Academisch Medisch Centrum Not yet recruiting Amsterdam, Noord-Holland, Netherlands, 1105 Contact: A.J. Bredenoord, M.D. A.J.Bredenoord@amc.uva.nl Sub-Investigator: A.J. Bredenoord, M.D. Tergooiziekenuizen Blaricum/Hilversum Not yet recruiting Hilversum/Blaricum, Noord-Holland, Netherlands, 1213/1261 Contact: Karen Verloop 0031 (35) 539 19 25 kverloop@tergooiziekenhuizen.nl Contact: B. van den Elzen, M.D. BvandenElzen@tergooiziekenhuizen.nl Sub-Investigator: B. van den Elzen, M.D. Collapse <<

Ebastine/依巴斯汀 Catalog No. CSN10883

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