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CAS No.: 95167-41-2

DY131 Catalog No. CSN10880

Synonyms: GSK 9089

DY131 is an agonist of ERRβ/ERRγ receptor (EC50 = 130 nM) with minimal activity for ERRα, ERα and ERβ.

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400-920-2911

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述The estrogen-related receptors (ERRs), including three isoforms, ERRα, β, and γ, are members of the nuclear receptor (NR) superfamily that encodes ligand-dependent DNA binding proteins that translate metabolic, nutritional and pathophysiological signals into gene regulation^[3]. DY131 is a potent and selective agonist ligand for ERRβ/γ and has no activity on the related receptors ERRα, ERα and Erβ^[4]. All cancer cell lines were completely growth-inhibited by the highest concentration (10 μM) of DY131, while MCF7, MDA-MB-231, and MDA-MB-468 were also significantly inhibited by 5 μM, and MCF7 and MDA-MB-468 cells by 2.5 μM. In clonogenic survival assays, MDA-MB-231 showed a dose-dependent reduction in colony formation after a single, 24 h exposure to DY131, while MCF7 cells showed reduced colony formation at 10 μM. Moreover, all breast cancer cell lines showed a significant, dose-dependent increase in the subG1 fraction, with MDA-MB-231 and MDA-MB-468 cells being the most sensitive by an increasing concentrations of DY131 treatment^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.2115 mL
- 16.0576 mL
- 32.1151 mL
- 5 mM
- 0.6423 mL
- 3.2115 mL
- 6.4230 mL
- 10 mM
- 0.3212 mL
- 1.6058 mL
- 3.2115 mL

技术信息

CAS号

95167-41-2

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C18H21N3O2

运输

蓝冰

分子量

311.38

别名

GSK 9089

溶解度

DMSO	250.0 mg/mL (802.9 mM)
Water	insoluble

动物实验配方

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DY131 Catalog No. CSN10880

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