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CAS No.: 562-10-7

Doxylamine succinate/琥珀酸多西拉敏 Catalog No. CSN10864

Synonyms: Doxylamine (succinate);NSC 74772;Doxylamine Succinate

Doxylamine Succinate Salt is an antihistamine which inhibits histamine H1 receptors. It can be used as a short-term sedative and anticholinergic agent.

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描述Doxylamine succinate is a commonly used antihistamine for respiratory allergies including allergic rhinitis as well as for the management of insomnia. Delirium, seizures, and coma are among the central adverse effects that are rare^[3]. High-fat, high-calorie food intake does not affect the kinetics of doxylamine in healthy subjects^[4]. Mean maximum observed plasma concentration (Cmax) and area under the concentration-time curve from time zero to time t (AUCt ) of doxylamine hydrogen succinate 12.5 mg and 25 mg tablets increased linearly and dose-dependently [12.5 mg: mean Cmax 61.94 ng/mL, coefficient of variation (CV) 23.2%; mean AUCt 817.33 ng·h/mL, CV 27.4%; and 25 mg: mean Cmax 124.91 ng/mL, CV 18.7%; mean AUCt 1630.85 ng·h/mL, CV 22.8%]. Doxylamine hydrogen succinate was safe and well tolerated^[5]. Doxylamine succinate (DA) was formerly used as an antinauseant during pregnancy, showed no substantial mutagenicity in mouse embryos following transplacental exposure^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.5743 mL
- 12.8714 mL
- 25.7428 mL
- 5 mM
- 0.5149 mL
- 2.5743 mL
- 5.1486 mL
- 10 mM
- 0.2574 mL
- 1.2871 mL
- 2.5743 mL

技术信息

CAS号

562-10-7

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C21H28N2O5

运输

蓝冰

分子量

388.46

别名

Doxylamine (succinate);NSC 74772;Doxylamine Succinate;Decapryn;Unisom;Evigoa D;A-H Injection;562-10-7;琥珀酸多西拉敏

溶解度

DMSO	80.0 mg/mL (205.9 mM)

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