生物活性

• 描述Doxazosin is a quinazoline-derivative that selectively antagonizes postsynaptic α1-adrenergic receptors.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT00741585	Essential Hypertension ... more >> Cardiovascular Disease Stroke Chronic Kidney Disease Collapse <<	Phase 4	Completed	-	Spain ... more >> CS Friol Friol, Lugo, Spain, 27220 CS Baiona Baiona, Pontevedra, Spain, 36300 CS Bueu Bueu, Pontevedra, Spain, 36930 CS A Estrada La Estrada, Pontevedra, Spain, 26680 CS A Guarda La Guardia, Pontevedra, Spain, 36780 CS Valmiñor Nigran, Pontevedra, Spain, 36250 CS Panxón Nigrán, Pontevedra, Spain, 36340 CS Tomiño Tomiño, Pontevedra, Spain, 36200 Bioengineering & Chronobilogy Labs., University of Vigo Vigo, Pontevedra, Spain, 36200 Hospital do Meixoeiro Vigo, Pontevedra, Spain, 36200 CS Calle Cuba Vigo, Pontevedra, Spain, 36202 CS A Doblada Vigo, Pontevedra, Spain, 36205 CS Coia Vigo, Pontevedra, Spain, 36209 CS Sardoma Vigo, Pontevedra, Spain, 36214 CS Teis Vigo, Pontevedra, Spain, 36216 CS Vilaboa Vilaboa, Pontevedra, Spain, 36141 CS San Roque Vilagarcía De Arousa, Pontevedra, Spain, 36600 CS Fingoi Lugo, Spain, 27002 Complexo Hospitalario Universitario de Ourense Orense, Spain, 32005 CS Lerez Pontevedra, Spain, 36156 Collapse <<
  NCT00295542	Hypertension	Phase 4	Completed	-	Spain ... more >> Hospital Clinico Universitario Santiago de Compostela, Spain, 15706 Collapse <<
  NCT00004266	Diabetic Nephropathy	Phase 3	Completed	-	United States, Minnesota ... more >> Hennepin County Medical Center Minneapolis, Minnesota, United States, 55415 Collapse <<

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• 参考文献

• [1] Sun JA, Kong DZ, et al. Stereoselective binding of doxazosin enantiomers to plasma proteins from rats, dogs and humans in vitro. Acta Pharmacol Sin. 2013 Dec;34(12):1568-74.

  [2] D'Eletto RD, Javitt NB. Effect of doxazosin on cholesterol synthesis in cell culture. J Cardiovasc Pharmacol. 1989;13 Suppl 2:S1-4;