|5,7-二碘喹啉-8-醇|CsnPharm

CAS No.: 83-73-8

Diiodohydroxyquinoline/5,7-二碘喹啉-8-醇 Catalog No. CSN16477

Synonyms: Iodoquinol;5,7-Diiodo-8-hydroxyquinoline;5,7-Diiodo-8-quinolinol

Diiodohydroxyquinoline is a quinoline derivative used in the treatment of amoebiasis.

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技术信息

生物活性

描述Diiodohydroxyquinoline (DIHQ) is a promising anticlostridial drug. DIHQ exhibited potent activity against 39 C. difficile isolates, inhibiting growth of 50% and 90% of these isolates at the concentrations of 0.5 μg/mL and 2 μg/mL, respectively. In a time-kill assay, DIHQ was superior to vancomycin and metronidazole, reducing a high bacterial inoculum by 3-log10 within six hours. Additionally, DIHQ did not inhibit growth of key species that compose the host intestinal microbiota, such as Bacteroides, Bifidobacterium and Lactobacillus spp^[3]. Diiodohydroxyquinoline (DIHQ) is also used as a common antiamebic drug that it exhibits mutagenic activity in the in vivo micronucleus test in Swiss albino mice. Ascorbic acid acts as an antimutagen against DIHQ^[2].
参考文献

[1] Ali NW, Gamal M, Abdelkawy M. Chromatographic methods for simultaneous determination of diiodohydroxyquinoline and metronidazole in their binary mixture. Pak J Pharm Sci. 2013 Sep;26(5):865-71.
[2] Ghaskadbi S, Vaidya VG. In vivo antimutagenic effect of ascorbic acid against mutagenicity of the common antiamebic drug diiodohydroxyquinoline. Mutat Res. 1989;222(3):219–222
[3] Abutaleb NS, Seleem MN. Repurposing the antiamoebic drug diiodohydroxyquinoline for treatment of Clostridioides difficile infections [published online ahead of print, 2020 Apr 6]. Antimicrob Agents Chemother. 2020;AAC.02115-19

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.5192 mL
- 12.5960 mL
- 25.1920 mL
- 5 mM
- 0.5038 mL
- 2.5192 mL
- 5.0384 mL
- 10 mM
- 0.2519 mL
- 1.2596 mL
- 2.5192 mL

技术信息

CAS号

83-73-8

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C9H5I2NO

运输

蓝冰

分子量

396.95

别名

Iodoquinol;5,7-Diiodo-8-hydroxyquinoline;5,7-Diiodo-8-quinolinol;5,7-Diiodoquinolin-8-Ol;Diiodohydroxyquin;Diiodoquin;Diquinol;Sebaquin

溶解度

DMSO	13.0 mg/mL (32.7 mM)
Water	Insoluble
Ethanol	Insoluble

动物实验配方

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Diiodohydroxyquinoline/5,7-二碘喹啉-8-醇 Catalog No. CSN16477

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