|地芰脱皂苷|CsnPharm

CAS No.: 11024-24-1

Digitonin/洋地黄皂苷 Catalog No. CSN10810

Synonyms: Digitin;NSC 23471;NSC 237417

Digitonin is a natural product isolated and purified from the herbs of Digitalis purpurea.

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生物活性

实验方案

技术信息

生物活性

描述Digitonin, a glycoside obtained from Digitalis purpurea, could increase cell permeability by binding to cholesterol molecules and reduce tumor growth. Digitonin enhanced the tumour-growth-retarding effect of CBDCA (carboplatin) given intra-arterially at 5 mg/kg but not at 25 mg/kg. Pretreatment with digitonin increases the tumour uptake of CBDCA and potentiates the cytotoxic effect of CBDCA^[1]. Digitonin is thus useful both for selectively permeabilizing the plasma membrane and for intensifying the appearance of intracellular structures such as microfilaments that are normally difficult to observe in cells such as hepatocytes^[2]. Perfusing a rat liver with digitonin in the concentration range 2-20 mg/ml results in complete decolorization of the organ within 45-250s^[3]. The activity of rat liver microsomal squalene epoxidase is inhibited effectively by digitonin. The inhibition of squalene epoxidase by digitonin is concentration-dependent and takes place rapidly within 5 min of exposure of the microsomes to digitonin. Only 40% inhibition of cyclase activity is observed at 1 mg/ml of digitonin^[4].

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 0.8135 mL
- 4.0673 mL
- 8.1346 mL
- 5 mM
- 0.1627 mL
- 0.8135 mL
- 1.6269 mL
- 10 mM
- 0.0813 mL
- 0.4067 mL
- 0.8135 mL

技术信息

CAS号

11024-24-1

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C56H92O29

运输

蓝冰

分子量

1229.31

别名

Digitin;NSC 23471;NSC 237417;洋地黄皂苷

溶解度

DMSO	95.0 mg/mL (77.3 mM) warming
Water	50.0 mg/mL (40.7 mM) warming

动物实验配方

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