|甘草酸二铵|CsnPharm

CAS No.: 79165-06-3

Diammonium Glycyrrhizinate/甘草酸二铵盐 Catalog No. CSN17218

Synonyms: 甘草酸二铵

Diammonium glycyrrhizinate is a natural product isolated and purified from the roots of licorice with antiviral, anti-inflammatory, and protective activities, can inhibit airway smooth muscle proliferation possibly through up- regulation of PPARγ in a murine model of chronic asthma.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Diammonium Glycyrrhizinate, the salt form of Glycyrrhizin, isolated from the licorice root, is a widely used anti-inflammatory agent. Diammonium Glycyrrhizinate could reduce inflammatory injury in a rat model of ulcerative colitis. This may occur via suppression of NF-kappaB, TNF-alpha and ICAM-1 in colonic mucosa^[3]. DG (Diammonium Glycyrrhizinate) pre-treatment significantly decreased the serum ALT and AST levels and improved the histological damage in Con A-induced autoimmune liver injury. Pre-treatment with DG down-regulated the inflammatory cytokines upon challenge with Con A. The DG pre-treatment inhibited the apoptosis of T lymphocytes in the thymus. Further, it effectively suppressed the proliferation of CD4+CD25-CD69+ and CD8+CD69+ subsets in the peripheral blood and spleen. In addition, the DG pretreatment significantly downregulated the frequency of NKT cells, while upregulating the frequency of Tregs in the liver^[4]. DG inhibited PDCoV (Porcine deltacoronavirus) replication in LLC-PK1 cells in a dose-dependent manner^[5]. DG could attenuate Aβ(1-42)-induced neuronal injury by preventing mitochondrial dysfunction and oxidative stress and improved cognitive impairment in Aβ(1-42)-induced AD mice, indicating that DG exerted potential beneficial effects on AD^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03550651	Mild Gingivitis ... more >> Periodontal Diseases Plaque Collapse <<	Not Applicable	Completed	-	-
NCT02961413	-	-	Recruiting	December 2018	China ... more >> Renji hospital Recruiting Shanghai, China Contact: Yimin Mao Collapse <<
NCT03274427	HCC	Phase 3	Recruiting	July 2021	China, Henan ... more >> The First Affiliated Hospital of Zhengzhou University Recruiting Zhengzhou, Henan, China, 450000 Collapse <<

更多
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.1669 mL
- 5.8344 mL
- 11.6687 mL
- 5 mM
- 0.2334 mL
- 1.1669 mL
- 2.3337 mL
- 10 mM
- 0.1167 mL
- 0.5834 mL
- 1.1669 mL

技术信息

CAS号

79165-06-3

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C42H68N2O16

运输

蓝冰

分子量

856.99

别名

甘草酸二铵

溶解度

DMSO	185.0 mg/mL (215.9 mM)
Water	185.0 mg/mL (215.9 mM)

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT03550651	Mild Gingivitis ... more >> Periodontal Diseases Plaque Collapse <<	Not Applicable	Completed	-	-
NCT02961413	-	-	Recruiting	December 2018	China ... more >> Renji hospital Recruiting Shanghai, China Contact: Yimin Mao Collapse <<
NCT03274427	HCC	Phase 3	Recruiting	July 2021	China, Henan ... more >> The First Affiliated Hospital of Zhengzhou University Recruiting Zhengzhou, Henan, China, 450000 Collapse <<
NCT03278444	HCC	Phase 3	Recruiting	July 2021	China, Henan ... more >> The First Affiliated Hospital of Zhengzhou University Recruiting Zhengzhou, Henan, China, 450000 Collapse <<
NCT03117153	Periodontitis ... more >> Gingivitis Collapse <<	Not Applicable	Completed	-	-
NCT00945568	Hepatocellular Carcinoma ... more >> Chronic Liver Disease Collapse <<	Not Applicable	Completed	-	Japan ... more >> Kochi Medical School Nankoku, Kochi, Japan, 783-8505 Kochi Medical School, Kochi University Nankoku-City, Kohasu-Okocho, Japan, 783-8505 Collapse <<
NCT00956891	-	-	Completed	-	China, Guangdong ... more >> The Third Affiliated Hospital Of Sun Yat-sen University Guangzhou, Guangdong, China, 510630 Collapse <<
NCT01742702	-	-	Recruiting	December 2021	Finland ... more >> Tampere University Hospital Recruiting Tampere, Finland Contact: Ilkka Pörsti, Professor ilkka.porsti@uta.fi Principal Investigator: Ilkka Pörsti, MD, PhD, Professor University of Tampere Recruiting Tampere, Finland Contact: Ilkka Pörsti, MD, PhD, Professor ilkka.porsti@uta.fi Principal Investigator: Ilkka Pörsti, Professor Collapse <<
NCT01271296	Addison Disease	Not Applicable	Completed	-	Norway ... more >> Haukeland University Hospital, Helse-Bergen HF Bergen, Norway, 5020 Collapse <<
NCT02251678	Plaque Psoriasis	Phase 1	Completed	-	United States, Illinois ... more >> NMFF Dermatology Clinic Chicago, Illinois, United States, 60611 NM Lake Forest Hospital/ Women's Center Lake Forest, Illinois, United States, 60045 United States, New Jersey TKL Research Fair Lawn, New Jersey, United States, 07410 United States, Ohio University Hospitals Case Medical Center / Dept of Dermatology Cleveland, Ohio, United States, 44106 Collapse <<
NCT02473458	Acute Stroke	Phase 1 Phase 2	Completed	-	Iran, Islamic Republic of ... more >> Emergency Departement of Namazi hospital Shiraz, Fars, Iran, Islamic Republic of Collapse <<
NCT02449122	Lung Cancer	Phase 1 Phase 2	Completed	-	China, Guangdong ... more >> Central laboratory in Fuda cancer hospital Guangzhou, Guangdong, China, 510000 Collapse <<
NCT02449135	Pancreatic Cancer	Phase 1 Phase 2	Completed	-	China, Guangdong ... more >> Central laboratory in Fuda cancer hospital Guangzhou, Guangdong, China, 510000 Collapse <<
NCT02449109	Liver Cancer	Phase 1 Phase 2	Completed	-	China, Guangdong ... more >> Central laboratory in Fuda cancer hospital Guangzhou, Guangdong, China, 510000 Collapse <<
NCT03266146	Drug-induced Liver Injury,Chro... more >>nic Collapse <<	Phase 1 Phase 2	Recruiting	August 27, 2021	China ... more >> Beijing 302 hospital Recruiting Beijing, China, 100039 Contact: Zhengsheng Zou, Dr. +8601066933424 zszou302@163.com Principal Investigator: Zhengsheng Zou, Dr. Collapse <<
NCT00686881	Hepatitis C, Chronic	Phase 3	Terminated(This study was term... more >>inated due to low enrollment) Collapse <<	-	-
NCT03306745	Polycystic Ovary Syndrome ... more >> Infertility, Female Micronutrient Deficiency Collapse <<	Not Applicable	Completed	-	Austria ... more >> Medical University of Vienna, Clinical Division of Gynecologic Endocrinology and Reproductive Medicine Vienna, Austria, 1090 Collapse <<
NCT01342185	Chronic Hepatitis B	Phase 3	Unknown	July 2013	China, Guangdong ... more >> Nanfang Hospital GuangZhou, Guangdong, China, 510000 Collapse <<
NCT02331745	Liver Failure ... more >> Hepatitis B Alcoholic Liver Disease Collapse <<	Phase 4	Unknown	October 2016	China ... more >> Beijing; 302 Military Hospital Recruiting Beijing, China, 100039 Contact: Jinbiao Ding, Dr. 86106693462 dingjb163@163.com Collapse <<
NCT00686881	-	-	Terminated(This study was term... more >>inated due to low enrollment) Collapse <<	-	-
NCT02329314	-	-	Unknown	June 2016	China, Shanghai ... more >> Shuguang Hospital Recruiting Shanghai, Shanghai, China Contact: Sun Mingyu, professor 86-21-20256526 mysun248@hotmail.com Collapse <<
NCT01643447	Hepatocellular Carcinoma	Not Applicable	Completed	-	China, Shanghai ... more >> Eastern Hepatobiliary Surgery Hospital Shanghai, Shanghai, China Collapse <<
NCT02651350	Drug-induced Liver Injury,Chro... more >>nic Collapse <<	Phase 1 Phase 2	Active, not recruiting	December 2019	China, Beijing ... more >> Beijing 302 hospital,China Beijing, Beijing, China, 100039 Collapse <<
NCT02812121	Liver Failure	Phase 2	Unknown	June 2018	-
NCT03349008	Chronic Hepatitis b ... more >> Liver Inflammation Collapse <<	Phase 4	Not yet recruiting	May 31, 2020	-

Diammonium Glycyrrhizinate/甘草酸二铵盐 Catalog No. CSN17218

靶点选择性

请登录您的专属账户

确认信息