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CAS No.: 57-71-6

二乙酰一肟 Catalog No. CSN23546

Synonyms: Diacetyl monoxime;DAM;2,3-Butanedione-2-monoxime

Diacetyl Monoxime is an inhibitor of skeletal muscle myosin-II.

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技术信息

生物活性

描述Diacetyl monoxime (DAM) is a negative inotropic agent. DAM (0.2-20 mM) inhibited the contractile force in both normal and 22 mM KCl-depolarized (in presence of 10^-6 M isoproterenol) guinea-pig papillary muscles in a concentration-dependent manner. In general, there was a lack of major effects of DAM on sarcolemmal electrical properties. The fast action potentials were somewhat depressed and the slow action potentials were slightly enhanced^[1]. In chemically skinned pig ventricular muscles, the myofibrillar contraction induced in 6.25 pCa was inhibited by DAM in a similar concentration range. Chemical uncouplers diacetyl monoxime (DAM) and cytochalasin D (cyto-D) are used to abolish cardiac contractions in optical studies, yet alter intracellular Ca²⁺ concentration ([Ca²⁺](i)) handling and vulnerability to arrhythmias in a species-dependent manner^[2]. In the indirectly stimulated rat diaphragm, diacetyl monoxime decreased the height of a single twitch, but a tetanus was well sustained. Diacetyl monoxime reduced the response to direct stimulation of both the rat diaphragm and cat muscles. Diacetyl monoxime injected intra-arterially in the cat elicited a transient hypertension and a gasp. Diacetyl monoxime did not reverse the neuromuscular block caused by anticholinesterases either in isolated rat phrenic nerve-diaphragm preparations or in cats^[3].
参考文献

[1] Li T, Sperelakis N, Teneick RE, Solaro RJ. Effects of diacetyl monoxime on cardiac excitation-contraction coupling. J Pharmacol Exp Ther. 1985 Mar;232(3):688-95
[2] Baker LC, Wolk R, Choi BR, Watkins S, Plan P, Shah A, Salama G. Effects of mechanical uncouplers, diacetyl monoxime, and cytochalasin-D on the electrophysiology of perfused mouse hearts. Am J Physiol Heart Circ Physiol. 2004 Oct;287(4):H1771-9
[3] EDERY H. Effects of diacetyl monoxime on neuromuscular transmission. Br J Pharmacol Chemother. 1959 Sep;14(3):317-22

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 9.8912 mL
- 49.4560 mL
- 98.9120 mL
- 5 mM
- 1.9782 mL
- 9.8912 mL
- 19.7824 mL
- 10 mM
- 0.9891 mL
- 4.9456 mL
- 9.8912 mL

技术信息

CAS号

57-71-6

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C4H7NO2

运输

蓝冰

分子量

101.10

别名

Diacetyl monoxime;DAM;2,3-Butanedione-2-monoxime;BDM;NSC 660;NSC 116103;双乙酰一肟

溶解度

DMSO	18.0 mg/mL (178.0 mM)
Water	18.0 mg/mL (178.0 mM)
Ethanol	18.0 mg/mL (178.0 mM)

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