|11-(4-甲基哌嗪-1-基)-5H-二苯并[b,E] [1,4]二氮杂卓|CsnPharm

CAS No.: 1977-07-7

Deschloroclozapine/氯氮平杂质 Catalog No. CSN21976

Dopamine serotonin antagonist-1 is antagonist of dopamine and serotonin receptor, the Kis for dopamine D1/D2/D4, and serotonin S2A/S2C/S3 are 200/2500/420 nM and 39/84/40 nM, respectively.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Dopamine serotonin antagonist-1 (5-HT antagonist 1) is a potent and selective antagonist of serotonin 3 (5-HT3) receptor. 5-HT induces phenotypic changes of nociceptors and peripheral injection induces pain in humans and nociceptive response in rodents^[1]. The pre-administration of WAY100635 (selective 5-HT1A receptor antagonist, 0.1 mg/kg, subcutaneous route), ketanserin (5-HT2A/2C receptor antagonist, 1 mg/kg, intraperitoneal route, i.p.), and chlorophenylalaninemethyl ester (p-CPA) (selective tryptophan hydroxylase inhibitor, 100 mg/kg, i.p., for 4 days), but not of ondansetron (selective 5-HT3 receptor antagonist, 1 mg/kg, i.p.), abolished the antidepressant-like action of SeBZF1 (50 mg/kg, intragastric route, i.g.)^[2]. The potentiation of HAL(5-HT receptor antagonists on haloperidol)-induced EPS by 5-HTP (50mg/kg, i.p.) was significantly inhibited by ritanserin (5-HT(2) antagonist, 0.3-3mg/kg, i.p.), ondansetron (5-HT(3) antagonist, 0.1-1mg/kg, i.p.), or SB-258585 (5-HT(6) antagonist, 1-10mg/kg, i.p.) in a dose-dependent manner. In addition, both ondansetron (0.1-1mg/kg, i.p.) and SB-258585 (3 and 10mg/kg, i.p.) also alleviated bradykinesia and catalepsy induced by HAL (0.5mg/kg, i.p.) alone in mice. Furthermore, bilateral microinjection of ondansetron (5 μg (13.7 nmol) per side) or SB-258585 (5 μg (8.92 nmol) per side) into the dorsolateral striatum (dlST) attenuated haloperidol-induced catalepsy in rats^[3].
参考文献

[1] Nascimento EB Jr, Seniuk JG, Godin AM, Ferreira WC, Dutra MB, Oliveira AC, Bastos LF, Fiebich BL, Coelho MM. Peripheral 5-HT1B and 5-HT2A receptors mediate the nociceptive response induced by 5-hydroxytryptamine in mice. Pharmacol Biochem Behav. 2011 Oct;99(4):598-603
[2] Gall JI, Gonçalves Alves A, Carraro Júnior LR, da Silva Teixeira Rech T, Dos Santos Neto JS, Alves D, Pereira Soares MS, Spohr L, Spanevello RM, Brüning CA, Folharini Bortolatto C. Insights into serotonergic and antioxidant mechanisms involved in antidepressant-like action of 2-phenyl-3-(phenylselanyl)benzofuran in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2020 Aug 30;102:109956
[3] Ohno Y, Imaki J, Mae Y, Takahashi T, Tatara A. Serotonergic modulation of extrapyramidal motor disorders in mice and rats: role of striatal 5-HT3 and 5-HT6 receptors. Neuropharmacology. 2011 Feb-Mar;60(2-3):201-8

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.4202 mL
- 17.1011 mL
- 34.2023 mL
- 5 mM
- 0.6840 mL
- 3.4202 mL
- 6.8405 mL
- 10 mM
- 0.3420 mL
- 1.7101 mL
- 3.4202 mL

技术信息

CAS号

1977-07-7

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C18H20N4

运输

蓝冰

分子量

292.38

别名

溶解度

DMSO	83.3 mg/mL (284.9 mM)

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

Deschloroclozapine/氯氮平杂质 Catalog No. CSN21976

靶点选择性

请登录您的专属账户

确认信息